A kind of long-acting breast injecting agent of benzathine cloxacillin and bismuth subnitrate compound

A technology of benzathine cloxacillin and breast injection, applied in the field of long-acting breast injection and its preparation, can solve the problems of uncontrollable opening and closing of nipple holes, incomplete infection prevention and control, etc., and achieve stable scar tissue without infiltration, The effect of good spreadability and good sustained release effect

Active Publication Date: 2018-05-25
宁夏智弘生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some antibiotic preparations can fully guarantee the bactericidal effect of cows throughout the dry milk period, they cannot control the opening and closing of teat holes, so the prevention and control of infection is not complete

Method used

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  • A kind of long-acting breast injecting agent of benzathine cloxacillin and bismuth subnitrate compound
  • A kind of long-acting breast injecting agent of benzathine cloxacillin and bismuth subnitrate compound
  • A kind of long-acting breast injecting agent of benzathine cloxacillin and bismuth subnitrate compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A long-acting breast injection of a complex of cloxacillin benzathine and bismuth subnitrate, consisting of the following components, measured by weight: 5 parts of cloxacillin benzathine, 20 parts of bismuth subnitrate, 20 parts of GTCC, carnauba 0.6 parts of wax, 20 parts of liquid paraffin, 2 parts of aluminum stearate, and 10 parts of stearic acid.

[0022] The preparation method of the long-acting breast injection of the benzathine cloxacillin and bismuth subnitrate compound, the specific steps are as follows:

[0023] (1) First mix GTCC, liquid paraffin, stearic acid, aluminum stearate and carnauba wax at 100-120°C to make it fully swell, then cool it down to room temperature as a base for later use;

[0024] (2) Fully mix cloxacillin benzathine and bismuth subnitrate with the above-mentioned standby matrix, place in a ball mill and grind until the particle size is below 10 μm to obtain the cloxacillin benzathine and bismuth subnitrate long-acting breast injector...

Embodiment 2

[0027] A long-acting breast injection of a complex of cloxacillin benzathine and bismuth subnitrate, consisting of the following components, measured by weight: 6 parts of cloxacillin benzathine, 25 parts of bismuth subnitrate, 25 parts of GTCC, carnauba 0.8 parts of wax, 20 parts of liquid paraffin, 3 parts of aluminum stearate, and 15 parts of stearic acid.

[0028] The preparation method of the long-acting breast injection of cloxacillin benzathine and bismuth subnitrate complex is the same as that in Example 1.

Embodiment 3

[0030] A long-acting breast injection of a complex of cloxacillin benzathine and bismuth subnitrate, consisting of the following components, measured by weight: 7 parts of cloxacillin benzathine, 30 parts of bismuth subnitrate, 30 parts of GTCC, carnauba 1 part of wax, 25 parts of liquid paraffin, 3.5 parts of aluminum stearate, 12 parts of stearic acid.

[0031] The preparation method of the long-acting breast injection of cloxacillin benzathine and bismuth subnitrate complex is the same as that in Example 1.

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PUM

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Abstract

The invention discloses a long-acting intramammary infusion adopting a cloxacillin benzathine and bismuth subnitrate complex and a preparation method of the long-acting intramammary infusion. The long-acting intramammary infusion comprises cloxacillin benzathine and bismuth subnitrate as effective components and comprises the components in parts by weight as follows: 5-10 parts of the cloxacillin benzathine, 20-50 parts of the bismuth subnitrate, 2-5 parts of aluminum stearate, 10-20 parts of stearic acid, 0.5-2 parts of carnauba wax, 20-40 parts of GTCC and 20-40 parts of liquid paraffin. The long-acting intramammary infusion can prolong the maintenance time of effective inhibitory concentration after drug administration, close an open mammary duct timely and can accelerate recovery of damaged mucosa and tissue of a mammary gland. The preparation method of the long-acting intramammary infusion adopts an advanced ball milling technology, effective components of the infusion have the advantages of small particle size, relatively uniform particle size distribution and high coating rate, a slow-release effect is lasting, stable and effective, and residues are avoided after a dry period ends.

Description

Technical field: [0001] The invention belongs to the field of veterinary drug preparations, in particular to the technical field of cow breast injections, and relates to a long-acting breast injection of a compound of cloxacillin benzathine and bismuth subnitrate and a preparation method thereof. Background technique: [0002] Cow mastitis is one of the diseases that cause the most serious loss in the dairy industry worldwide. In the United States alone, the loss caused by cow mastitis reaches 200 million US dollars every year. Especially invisible mastitis is difficult to detect, and can be generally popular in the herd again, so cause serious loss to dairy industry. According to reports, Staphylococcus aureus, Escherichia coli, and Streptococcus are important pathogenic bacteria that cause mastitis in dairy cows. These mastitis pathogenic microorganisms infect mammary gland tissue and cause mammary inflammation. Microorganisms that can cause udder infection are widely pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/24A61K9/00A61K47/14A61K47/44A61P15/14A61P31/04A61K31/431
CPCA61K9/0002A61K9/0041A61K31/431A61K33/245A61K47/14A61K47/44A61K2300/00
Inventor 周学章张玉彦朱秀春安政崔生玲马桂花
Owner 宁夏智弘生物科技有限公司
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