Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Lemon peel pellet and preparation method thereof

A technology of lemon peel and pellets, applied in the field of medicine and food, to achieve high bioavailability and rapid onset of effect

Inactive Publication Date: 2016-04-20
JF PHARMALAND TECH DEV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, products related to lemon peel are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the disintegration time of the above dosage forms is long; It disintegrates at a certain point in the body, which is irritating to the gastric mucosa; low bioavailability and other disadvantages

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take the following ingredients for the recipe

[0029] Lemon Peel Extract 10g

[0030] Microcrystalline cellulose 82g

[0031] Hydroxypropyl Methyl Cellulose 4g

[0032] Prepare pellet formulations as follows:

[0033] (1) Take the lemon peel of the above formula, add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0037] Take the following ingredients for the recipe

[0038] Lemon Peel Extract 15g

[0039] Starch 85g

[0040] Polyvinylpyrrolidone 5g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the lemon peel of the above formula, add starch, pulverize it to a micronized level with a ball mill, and mix well;

[0043] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0044] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Lemon Peel Extract 8g

[0048] Sucrose 49g

[0049] Starch 34g

[0050] Polyvinylpyrrolidone 4g

[0051] Prepare pellet formulations as follows:

[0052] (1) Take the lemon peel of the above formula, add sucrose and starch, pulverize it to a micronized level with a ball mill, and mix well;

[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a lemon peel extract pellet preparation. The lemon peel extract pellet preparation is prepared from lemon peel extract and pharmaceutical adjuvant and is characterized in that the pharmaceutical adjuvant is composed of an excipient and an adhesive and the weight percentages of the lemon peel extract, the excipient and the adhesive are 10 to 30%, 65 to 85% and 1 to 5%, respectively. The pellet preparation provided by the invention has a high dissolution rate and high bioavailability; and the preparation method for the pellet preparation is simple, convenient and easily practicable.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a lemon peel pellet and a preparation method thereof. Background technique: [0002] At present, products related to lemon peel are widely recognized by consumers, and they are basically ordinary tablets and capsules. Irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0003] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are generally added during the preparation of pellet preparations ["Design and Development of Sustained and Controlled Release Preparations", Yan Yaodong et al., Chinese ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/16A23L1/29
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com