Bispecific CD3 and CD19 antigen binding constructs

A bispecific, construct technology, applied in the direction of antibodies, anti-receptors/cell surface antigens/cell surface determinants, immunoglobulins, anti-inflammatory agents, etc. Anti-adverse in vivo half-life and other issues
CN105531374AInactive Publication Date: 2016-04-27ZYMEWORKS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZYMEWORKS INC
Publication Date
2016-04-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Bispecific antigen binding constructs are described that bind to CD3 and CD19 or CD20 antigens.
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Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims U.S. Provisional Application Nos. 61 / 845,948, filed July 12, 2013 and U.S. Provisional Application Nos. 61 / 927,877, filed January 15, 2014 and 61 / 978,719, filed April 11, 2014 Benefits of U.S. Provisional Applications. These applications are hereby incorporated by reference in their entirety.

[0003] sequence listing

[0004] This application contains a Sequence Listing, which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. The ASCII copy was created in XX, 2014, named XXXXX_CRF_sequencelisting.txt, and the size is XXX,XXX bytes. technical field

[0005] The field of the invention is the rational design of multispecific scaffolds, such as antigen binding constructs comprising CD3 binding domains for custom development of biotherapeutics. Background of the invention

[0006] In the field of therapeutic proteins, antibodies with their multivalent target ...

Claims

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