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Medicine for treating vitiligo made from angelica and tribulus and its preparation method and application

A vitiligo and drug technology, applied in drug combinations, sugar-coated pills, pharmaceutical formulations, etc., can solve the problems of depigmentation, lack of trace elements, affecting melanin metabolism, etc.

Active Publication Date: 2017-03-01
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 5. The theory of trace element deficiency: the level of copper or ceruloplasmin in the blood and skin of patients with vitiligo decreases, resulting in a decrease in the activity of tyrosinase, thus affecting the metabolism of melanin
[0016] 3. General hair: all or almost all pigment loss
The latter has a positive reaction to DOPA, the melanocytes have not disappeared but the number has decreased, and the chance of cure is high

Method used

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  • Medicine for treating vitiligo made from angelica and tribulus and its preparation method and application
  • Medicine for treating vitiligo made from angelica and tribulus and its preparation method and application
  • Medicine for treating vitiligo made from angelica and tribulus and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] Prescription: Angelica 333g, Tribulus terrestris 333g, Black Guma 333g.

[0210] Preparation: Take 333g of dried Angelica sinensis, 333g of Tribulus terrestris, and 333g of black bone marrow, add 5000mL of water to decoct, decoct twice, 1 hour each time, combine the extracts, filter, concentrate the filtrate, dry, add appropriate amount of dextrin, mix Evenly, make granules, pack into capsules, and make 1000 hard capsules.

[0211] Content determination:

[0212] Use high-performance liquid chromatography to carry out content determination to Tribulus terrestris amide:

[0213] (1) Chromatographic conditions: using HypersilDs chromatographic column; mobile phase: acetonitrile-0.05mol / L sodium dihydrogen phosphate solution at a ratio of 30:70; detection wavelength: 200nm; column temperature: 20°C; flow rate: 1.0mL·min -1 ;Injection volume: 10μL;

[0214] (2) Preparation of reference substance solution: Accurately weigh an appropriate amount of Tribulamide reference su...

Embodiment 2

[0226] Prescription: Angelica 166g, Tribulus terrestris 332g, Black Guma 498g.

[0227] Preparation method: Take 166g of dried angelica, 332g of Tribulus terrestris, and 498g of black bone, add 8000mL of water to decoct, decoct twice, each time for 1 hour, combine the extracts, filter, concentrate the filtrate, add appropriate amount of starch, stearic acid Magnesium, mixed evenly, made into granules, dried, compressed into tablets, coated, made into 1000 tablets.

[0228] Content determination:

[0229] Use high-performance liquid chromatography to carry out content determination to Tribulus terrestris amide:

[0230] (1) Chromatographic conditions: using HypersilDs chromatographic column; mobile phase: acetonitrile-0.05mol / L sodium dihydrogen phosphate solution at a ratio of 30:70; detection wavelength: 200nm; column temperature: 20°C; flow rate: 1.0mL·min -1 ;Injection volume: 10μL;

[0231] (2) Preparation of reference substance solution: Accurately weigh an appropriate...

Embodiment 3

[0243] Prescription: Angelica 286g, Tribulus terrestris 429g, Black Guma 286g.

[0244] Preparation method: Take 286g of dried angelica, 429g of Tribulus terrestris, and 286g of black bone, add 7000mL of water to decoct, decoct 3 times, 0.5 hours each time, combine the extracts, filter, concentrate the filtrate, add appropriate amount of starch, and make Pills, dried, made into 5000 pills.

[0245] Content determination:

[0246] Use high-performance liquid chromatography to carry out content determination to Tribulus terrestris amide:

[0247] (1) Chromatographic conditions: using HypersilDs chromatographic column; mobile phase: acetonitrile-0.05mol / L sodium dihydrogen phosphate solution at a ratio of 30:70; detection wavelength: 200nm; column temperature: 20°C; flow rate: 1.0mL·min -1 ;Injection volume: 10μL;

[0248] (2) Preparation of reference substance solution: Accurately weigh an appropriate amount of Tribulamide reference substance dried at 80°C to constant weight,...

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Abstract

The invention belongs to the field of traditional Chinese medicines and particularly relates to a pharmaceutical composition for treating leucoderma. The invention provides a medicine prepared from angelica and tribulus terrestris and used for treating leucoderma as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 1-3 parts of angelica, 1-3 parts of tribulus terrestris and 1-3 parts of sambucus chinensis. The pharmaceutical composition can be prepared into tablets, pills, hard capsules, granules and oral solutions by adopting a conventional pharmaceutical method in pharmacy. The pharmaceutical composition can be used for preparing the medicine for treating leucoderma.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicinal composition composed of angelica, tribulus terrestris and black bone marrow, which has the effect of treating vitiligo. Background technique [0002] Vitiligo is a common acquired localized or generalized skin depigmentation disease. It is caused by the loss of function of melanocytes in the skin, but the mechanism is still unclear. It can occur in various parts of the body, and it is common in the back of the fingers, wrist, forearm, face, neck and around the genitals. [0003] Cause: [0004] The cause of this disease is not clear. In recent years, studies have suggested that it is related to the following factors: [0005] 1. Genetic theory: Vitiligo can appear in twins and families, indicating that heredity plays an important role in the pathogenesis of Vitiligo. Studies suggest that vitiligo has incomplete penetrance, and there are multiple pathoge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P17/00A61P31/10G01N30/02
CPCA61K9/0095A61K9/1652A61K9/2059A61K9/28A61K36/185A61K36/232A61K36/48A61K2236/331A61K2236/39A61K2236/51G01N30/02G01N2030/027A61K2300/00
Inventor 安丽凤段剑飞张金良黄敬文鲁光宝刘海洲张丽宏王英莲
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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