Anti-human epidermal growth factor receptor 2 monoclonal antibody combined with nanomicelle and its preparation and application

A technology of epidermal growth factor and monoclonal antibody, which is applied in the field of biomedicine, can solve the problems of side effects, inability to distinguish cancer cells from normal cells, and toxicity, and achieve the effects of small side effects, superior anti-tumor activity, and reduced side effects

Active Publication Date: 2018-10-19
上海蓝西实验设备有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most clinical anticancer agents still cannot distinguish cancer cells from normal cells, resulting in systemic toxicity and serious side effects

Method used

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  • Anti-human epidermal growth factor receptor 2 monoclonal antibody combined with nanomicelle and its preparation and application

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Embodiment 1

[0030] 1. Structural modification of polyoxyethylene-polyoxypropylene-polyoxyethylene block polymers

[0031] a) Synthesis and characterization of carboxylated block polymer P123 (CT-P123);

[0032] The specific steps of polymer surface modification are: under the action of sodium hydroxide, the addition reaction of 2-butenenitrile and polyoxyethylene-polyoxypropylene-polyoxyethylene block polymer occurs, and then the addition reaction is carried out by stirring reaction The nitrile group contained in the product is hydrolyzed, and xylene is used to extract from the hydrolysis reaction product liquid to obtain a carboxyl PEO-PPO-PEO block copolymer product.

[0033] b) Linkage of CT-P123 and anti-HER2 monoclonal antibody:

[0034] The specific steps of linking the polymer molecule to the monoclonal antibody are as follows: the carboxyl activator 1-ethyl-(3-dimethylaminopropyl) carbodiimide (EDC) and polyoxyethylene-polyoxypropylene-polyoxygen Ethylene block polymer modificat...

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Abstract

The invention discloses a combined nano-micelle of monoclonal antibodies for resisting human epidermal receptors 2 and preparation and application of the combined nano-micelle. The nano-micelle is formed by connecting monoclonal antibodies for resisting human epidermal receptors 2 with carbonylation polyoxyethylene-polyoxypropylene-polyoxyethylene block polymers. The invention further discloses the immune micelle prepared by wrapping the monoclonal antibodies for resisting human epidermal receptors 2 as medicine carriers on taxol, and preparation and application of the immune micelle. By means of the immune micelle, medicine can be sent to a certain target position, the anti-tumor effects of taxol and antibodies for resisting human epidermal receptors 2 (HER2) are achieved, tumor cells are dead, and the acting time of medicine on a tumor part is prolonged; better anti-tumor activity and smaller toxic and side effects are achieved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to anti-human epidermal growth factor receptor 2 monoclonal antibody combined with nano micelles and its preparation and application. Background technique [0002] Breast cancer is a common malignant tumor occurring in the breast ductal epithelium in women. The incidence rate is (11-80) / 100,000, and the case fatality rate is (0.7-26.6) / 100,000, accounting for 7%-10% of various malignant tumors in the whole body. Breast cancer occurs all over the world, and has the highest incidence among gynecological tumors in many western countries. Breast cancer has seriously jeopardized the physical and mental health of Chinese women, and its incidence rate has shown an obvious upward trend in the past 20 years. It has occupied the top two tumor incidence rates among women in large cities in China. [0003] At present, the treatment of breast cancer mainly adopts surgery, supplemented by radiotherap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/42A61K31/337A61P35/00
Inventor 倪健
Owner 上海蓝西实验设备有限公司
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