Human lung adenocarcinoma cell LC-21 and application thereof

A technology of LC-21 and lung adenocarcinoma cells, applied in the field of human lung adenocarcinoma LC-21 cells, can solve the problems of small number of lung cancer cell lines and large differences in biological characteristics

Inactive Publication Date: 2016-05-11
SHANGHAI INST OF ONCOLOGY
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  • Abstract
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Problems solved by technology

However, the number of existing human lung cancer cell lines at home and abroad is not large, and the biological characteristics of each cell line ar...

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  • Human lung adenocarcinoma cell LC-21 and application thereof
  • Human lung adenocarcinoma cell LC-21 and application thereof
  • Human lung adenocarcinoma cell LC-21 and application thereof

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Embodiment Construction

[0014] After long-term research and repeated screening, the inventors have found a human lung adenocarcinoma LC-21 cell line with a high metastasis rate and high malignant degree of lung cancer. The human lung adenocarcinoma LC-21 cell line is an ideal A model for the study of tumor metastasis. The present invention has been accomplished based on this.

[0015] The present invention aims to clarify the growth and metastasis characteristics of human lung adenocarcinoma LC-21 cell line. The present invention named the cell line as human lung adenocarcinoma LC-21 cell line, and it was preserved in the China Center for Type Culture Collection on June 19, 2012, with the preservation number CCTCCNOC201287, and the address of China Type Culture Collection Center: Wuhan, China. Wuhan University.

[0016] Establishing human cancer cells in vitro is an important means to study human tumors. The in vitro culture and establishment of tumor cells is a difficult project, and the probabil...

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Abstract

The invention discloses a human lung adenocarcinoma cell LC-21, which belongs to the field of cytobiology. The human lung adenocarcinoma cell is characterized by being preserved in China Center for Type Culture Collection with an accession number of CCTCC No. C201287. The invention has the following advantages: (1) through repeated in-vitro screening, a human lung adenocarcinoma cell LC-21 cell line model and a human lung adenocarcinoma cell LC-21 cell line are successfully established, and the established model and cell line have a high metastasis rate, stable metastasis, good visualizability and strong targeting performance; and (2) the human lung adenocarcinoma cell LC-21 cell line provides an ideal model for prevention and cure research and anti-metastasis treatment of lung cancers.

Description

technical field [0001] The invention relates to the field of cell biology, in particular to human lung adenocarcinoma LC-21 cells and its application. Background technique [0002] Human-derived lung cancer cell lines are essential experimental materials and tools for basic and clinical research on lung cancer. The morbidity and mortality of lung cancer in my country are relatively high, and the establishment of lung cancer cell lines with Chinese ethnic characteristics is of great significance for the diagnosis, treatment, and molecular mechanism of metastasis of lung cancer. However, the number of existing human lung cancer cell lines at home and abroad is not large, and the biological characteristics of each cell line are quite different, which is far from meeting the needs of research. Therefore, it is urgent to establish more and more ideal lung cancer cell lines. strain. Contents of the invention [0003] The object of the present invention is to provide a human lu...

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Application Information

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IPC IPC(8): C12N5/09C12Q1/02C12R1/91
Inventor 闫明霞刘蕾林河春李静余涛邓未刘颖姚明
Owner SHANGHAI INST OF ONCOLOGY
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