Glabridin-cladded nano solid lipid carrier and preparation method and application thereof

The technology of glabridin and solid lipid is applied in the directions of skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., and can solve the problems of low bioavailability, poor stability and poor permeability of glabridin, and the like, To achieve the effect of promoting transportation, improving stability and skin absorption rate, and enhancing affinity

Inactive Publication Date: 2016-05-18
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of nano solid lipid carrier with high stability and good compatibility, which uses glabridin as active ingredient, so as to solve the problem of poor stability, poor permeability and low bioavailability of glabridin in the prior art. question

Method used

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  • Glabridin-cladded nano solid lipid carrier and preparation method and application thereof
  • Glabridin-cladded nano solid lipid carrier and preparation method and application thereof
  • Glabridin-cladded nano solid lipid carrier and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The nanometer solid lipid carrier coated with glabridin is calculated according to the total amount of 100g, and the formula is as follows:

[0044]

[0045]

[0046] Wherein, the solid emulsifier is sodium stearoyl glutamate;

[0047] The solid lipid is pentaerythritol distearate;

[0048] The liquid lipid is olive oil;

[0049] Described polyhydric alcohol is propylene glycol;

[0050] The phospholipid is soybean lecithin;

[0051] Described inorganic salt is potassium chloride;

[0052] The preservative is diazolidinyl urea.

[0053] The preparation steps of this embodiment are as follows:

[0054] 1), the preparation of oil phase system

[0055] Melt 0.02g glabridin, 2g solid emulsifier, 2g solid lipid, 1g liquid lipid, and 2g polyol at 85°C and disperse uniformly to obtain a uniformly dispersed oil phase;

[0056] 2), the preparation of aqueous phase system

[0057] Heat the aqueous phase consisting of 0.5g phospholipids, 0.02g inorganic salts and dei...

Embodiment 2

[0065] The nanometer solid lipid carrier coated with glabridin is calculated according to the total amount of 100g, and the formula is as follows:

[0066]

[0067] Wherein, the solid emulsifier is Gemini emulsifier;

[0068] The solid lipid is cetyl alcohol;

[0069] The liquid lipid is isopropyl myristate;

[0070] The polyhydric alcohol is glycerol;

[0071] The phospholipid is egg yolk lecithin;

[0072] Described inorganic salt is sodium chloride;

[0073] The preservative is methylparaben.

[0074] The preparation steps of this embodiment are as follows:

[0075] 1), the preparation of oil phase system

[0076] Melting and uniformly dispersing the aforementioned glabridin, solid emulsifier, solid lipid, liquid lipid, and polyhydric alcohol at a temperature of 100° C. to obtain a uniformly dispersed oil phase;

[0077] 2), the preparation of aqueous phase system

[0078] heating the aqueous phase composed of the aforementioned phospholipids, inorganic salts and...

Embodiment 3

[0086] The nanometer solid lipid carrier coated with glabridin is calculated according to the total amount of 100g, and the formula is as follows:

[0087]

[0088] Wherein, the solid emulsifier is sodium stearoyl glutamate;

[0089] The solid lipid is pentaerythritol distearate;

[0090] The liquid lipid is olive oil;

[0091] Described polyhydric alcohol is propylene glycol;

[0092] The phospholipid is soybean lecithin;

[0093] Described inorganic salt is potassium chloride;

[0094] The preservative is diazolidinyl urea.

[0095] The preparation steps of this embodiment are as follows:

[0096] 1), the preparation of oil phase system

[0097] Melting and uniformly dispersing the aforementioned glabridin, solid emulsifier, solid lipid, liquid lipid, and polyhydric alcohol at a temperature of 100° C. to obtain a uniformly dispersed oil phase;

[0098] 2), the preparation of aqueous phase system

[0099] heating the aqueous phase composed of the aforementioned pho...

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Abstract

A glabridin-cladded nano solid lipid carrier contains 0.02-8% of glabridin, 2-20% of a solid emulsifier, 2-15% of solid lipid, 1-15% of liquid lipid, 2-10% of polyols, 0.5-5% of phospholipid, 0.02-1% of inorganic salt, 0.01-0.8% of a preservative and deionized water. The invention further provides a preparation method of the glabridin-cladded nano solid lipid carrier. The stability of the glabridin is improved by the glabridin-cladded nano solid lipid carrier, the infiltration of the glabridin into the skin is promoted, and the skin whitening and anti-oxidation effects are improved.

Description

[0001] This application is based on the Chinese patent application number 201410713479.3, the applicant is Infinitus (China) Co., Ltd., and the name is "a nano-solid lipid carrier coated with glabridin and its preparation method and application" as a priority document. Apply. technical field [0002] The invention belongs to the technical field of carrier systems in cosmetic preparation technology, and in particular relates to a nanoscale carrier and a preparation method thereof, in particular to a nanometer solid lipid carrier coated with glabridin and a preparation method thereof. Background technique [0003] With the improvement of living standards, more people's demand for cosmetics has changed from a single care type to a functional type, such as whitening, freckle removal, and anti-acne. Fair skin has always been admired by oriental women, and the concept of whitening is gradually changing. In the 1970s, people relied on physical masking whitening agents such as "whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/49A61K8/92A61K8/55A61K8/60A61Q19/02
CPCA61K8/14A61K8/498A61K2800/413A61K2800/524A61K2800/56A61Q19/02
Inventor 张晨罗绍强唐青涛张志伟牛玉莲
Owner INFINITUS (CHINA) CO LTD
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