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Pharmaceutical composition for regulating blood lipid and preventing atherosclerosis

A technology for atherosclerosis and regulating blood lipids, which is applied in the preparation of the traditional Chinese medicine composition, the field of pharmaceutical compositions for regulating blood lipids and preventing atherosclerosis, which can solve the problems of abnormally elevated liver transaminase and muscle, and achieve the prevention of atherosclerosis Sclerosis, obvious effect, effect of lowering blood fat

Inactive Publication Date: 2016-05-18
CHONGQING TECH & BUSINESS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common adverse reactions of statins are abnormal elevation of liver transaminases and muscle lesions, and the most serious adverse reactions are rhabdomyolysis and peripheral neuropathy.

Method used

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  • Pharmaceutical composition for regulating blood lipid and preventing atherosclerosis
  • Pharmaceutical composition for regulating blood lipid and preventing atherosclerosis
  • Pharmaceutical composition for regulating blood lipid and preventing atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, the preparation of pharmaceutical composition and the effect verification of regulating blood fat

[0022] 1) The preparation method is as follows:

[0023] Coptis chinensis was sliced ​​and refluxed with 70% ethanol solution to extract 3 times. The amount of ethanol solution was calculated as 1 g of Coptis chinensis was added to 7 mL ethanol solution, and each extraction was performed for 0.5 hours. The extracts were combined, the solvent was recovered and concentrated to a concentration of 1 g / mL, for later use; Rhizoma Chuanxiong slices were reflux extracted with 60% ethanol aqueous solution for 3 times, the amount of ethanol aqueous solution was calculated as 1g of Chuanxiong Rhizoma Rhizoma Chuanxiong was added to 6mL ethanol aqueous solution, each extraction was 0.5 hours, the extracts were combined, the solvent was recovered and concentrated To a concentration of 1g / mL, set aside; stir-fry loofah, chop and extract 3 times with 1g of water and 10mL,...

Embodiment 2

[0049] Example 2. Verification of the preventive effect of the pharmaceutical composition on atherosclerosis

[0050] 1) The preparation method is as follows:

[0051] Coptis chinensis was sliced ​​and refluxed with 70% ethanol solution to extract 3 times. The amount of ethanol solution was calculated as 1 g of Coptis chinensis was added to 7 mL ethanol solution, and each extraction was performed for 0.5 hours. The extracts were combined, the solvent was recovered and concentrated to a concentration of 1 g / mL, for later use; Rhizoma Chuanxiong slices were reflux extracted with 60% ethanol aqueous solution for 3 times, the amount of ethanol aqueous solution was calculated as 1g of Chuanxiong Rhizoma Rhizoma Chuanxiong was added to 6mL ethanol aqueous solution, each extraction was 0.5 hours, the extracts were combined, the solvent was recovered and concentrated To a concentration of 1g / mL, set aside; stir-fry loofah, chop and extract 3 times with 1g of water and 10mL, each time...

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Abstract

The invention relates to a pharmaceutical composition for regulating blood lipid and preventing atherosclerosis. The pharmaceutical composition is prepared from the following raw materials in percentage by weight: 5-40% of coptis chinensis, 5-30% of loofah sponge, 1-20% of ligusticum wallichii, 5-20% of cycas recoluta flower, 5-20% of cinnamon, 1-20% of clove, 5-20% of irisensata thunb and 5-20% of myrrh. In the composition, the coptis chinensis and loofah sponge serve as monarch drugs and are in reasonable compatibility with the ligusticum wallichii, cinnamon, cycas recoluta flower, clove and irisensata thunb and then are assisted by the myrrh of proper proportion to realize synergism, the effect of regulating blood lipid is obvious, and a remarkable function of preventing atherosclerosis is realized. Moreover, the composition is small in size and convenient to prepare, carry and take; and the preparation method is simple, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, relates to a pharmaceutical composition for regulating blood lipid and preventing atherosclerosis, and also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases, characterized by lipid deposition in the intima of large and medium arteries, atherosclerotic plaque formation, fibrous tissue hyperplasia, and hardening of the vessel wall, eventually leading to Stenosis and even complete blockage can cause ischemia in vital organs such as the heart, brain, and kidneys, and become the leading cause of human death. Inflammation and dyslipidemia are the main drivers of AS. Abnormally elevated cholesterol levels, especially low-density lipoprotein cholesterol, will deposit on the arterial walls of large to medium-sized arteries to...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P3/06A61P9/10
CPCA61K36/13A61K36/236A61K36/328A61K36/42A61K36/54A61K36/61A61K36/718A61K36/81A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 冯敏孔淑贞
Owner CHONGQING TECH & BUSINESS UNIV
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