The invention discloses anti-oxidation grape wine which comprises the following raw materials: fresh grapes, mulberries, kiwi fruits, red date pulp, orange juice, peer juice, salvia miltiorrhiza, schisandra chinensis, astragalus membranaceus, Lycium barbarum, corn juice, broccoli juice, potherb mustard juice, white sugar, vanilla, yeast, catechinic acid and caffeic acid. The anti-oxidation grape wine is made of grapes as a main material, components with high medicinal values such as mulberries, kiwi fruits, red date pulp, orange juice, peer juice, salvia miltiorrhiza, schisandra chinensis, astragalus membranaceus, Lycium barbarum, corn juice, broccoli juice and potherb mustard juice are added, the formula is scientific and reasonable, and the substances are used in match and take effects into effect, so that the grape wine is rich in nutrition, rich in multiple bioactive substances, good in anti-oxidation function and capable of retarding aging and beatifying faces.