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Tropolone compound, pharmaceutical composition thereof as well as preparation method and applications of tropolone compound

A technology for tropolone and compound is applied in the field of tropolone compound and pharmaceutical composition and preparation thereof, and achieves the effects of good antioxidative and antifree radical activity and good protective effect

Active Publication Date: 2016-05-18
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the following tropolone compounds of the present invention and their activity

Method used

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  • Tropolone compound, pharmaceutical composition thereof as well as preparation method and applications of tropolone compound
  • Tropolone compound, pharmaceutical composition thereof as well as preparation method and applications of tropolone compound
  • Tropolone compound, pharmaceutical composition thereof as well as preparation method and applications of tropolone compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Preparation of compound:

[0028] (1) Fermentation strain: Streptomyces Streptomycessp.CGMCCNo.11535 (preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee on December 4, 2015, preservation address: Courtyard 3, No. 1 Beichen West Road, Chaoyang District, Beijing No., Institute of Microbiology, Chinese Academy of Sciences. Derived from, the biological material provided by Kunming Institute of Botany, Chinese Academy of Sciences: KIB033) is the starting strain,

[0029] (2) Incline culture: medium composition (g / L): soybean powder 20g / L, mannitol 20g / L, agar powder 20g / L, pH7.0~7.2, use deionized water to prepare, and constant volume, in Sterilize at 121°C for 20 minutes. After inoculation, they were placed in a 28°C incubator and cultured for 7 days.

[0030] (3) Seed culture: Seed medium composition (g / L): tryptone 17g / L, plant peptone 3g / L, sodium chloride 5g / L, dipotassium hydrogen phosphate 2.5g / L, glucose...

Embodiment 2

[0051] Compound 1-2 obtained in Example 1 was added with 4% sulfuric acid ethanol solution, pH = 4, filtered and dried to prepare sulfate compound 1-2.

Embodiment 3

[0053] Compound 1-2 obtained in Example 1 was added with 4% hydrochloric acid solution, pH = 4, filtered and dried to prepare the hydrochloride compound 1-2.

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PUM

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Abstract

The invention aims to provide a novel tropolone compound or a pharmaceutical salt of the tropolone compound, pharmaceutical composition taking the tropolone compound or the pharmaceutical salt as an active component, a preparation method of the tropolone compound, an application of the tropolone compound to preparation of drugs for treating or preventing myocardial cell damage as well as an application to preparation of antioxidants. The compound obtained with the method has very good antioxidant and anti-free-radical activity, has a good protection function for damage to H2O2 induced neonatal rat myocardial cells and can be used for preparing antioxidants and myocardial damage protective agents.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a tropolone compound, a pharmaceutical composition thereof, a preparation method and an application thereof. Background technique [0002] Natural product chemistry is an important branch of organic chemistry, a science that studies the metabolites of biological organisms and their changes at the molecular level. The rich and diverse organisms in nature are the source of natural product discovery, and the structure of natural products is diverse and complex, which is an important source for the creation of new drugs. Actinomycetes are one of the most widely distributed microbial groups in nature, and Streptomyces is the largest group of actinomycetes and an important producer of antibiotics. According to statistics, antibiotics produced by Streptomyces account for about 70% of antibiotics. Accounting for more than 90% of antibiotics produced by actinomycetes. Tropo...

Claims

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Application Information

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IPC IPC(8): C07D491/153C12P17/18A61P9/00A61P39/06C12R1/465
CPCC07D491/153C12P17/18
Inventor 黄胜雄纪旭颜一军杨静罗剑英
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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