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Method for extracting ginsenoside Rg5

A technology of ginsenosides and ginseng powder, applied in chemical instruments and methods, glycoside steroids, steroids, etc., to achieve the effects of mild experimental conditions, high extraction yield and short extraction time

Active Publication Date: 2016-05-25
JILIN PROVINCE CAISENREN BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no relevant report about extracting ginsenoside Rg5 directly from ginseng as raw material

Method used

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  • Method for extracting ginsenoside Rg5

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Effect test

Embodiment 1

[0027] A kind of extracting method of ginsenoside Rg5: get ginseng root, after it is pulverized, pass through 120 mesh sieves, get 0.5g ginseng powder, add the mixed solvent of n-butanol and water of 60 times of volume (the volume ratio of the two is 4:1) , adding hydrochloric acid to make the acid concentration 0.2mol / L, stirring and extracting in a 60°C water bath for 4h. The extract was centrifuged to separate the extract and the solid, and the solid was washed twice with saturated n-butanol, combined with the extract, and washed with saturated Na 2 CO 3 After the aqueous solution is neutralized, it is concentrated to dryness with a rotary evaporator at a temperature lower than 60° C. to obtain an extract containing ginsenoside Rg5.

Embodiment 2

[0029] A kind of extracting method of ginsenoside Rg5: get ginseng root, cross 100 mesh sieves after it is pulverized, get 0.5g ginseng powder, add the mixed solvent of methyl alcohol, n-butanol, water of 20 times of volumes (three volume ratios are 3 :5:2), add sulfuric acid to make the acid concentration 0.1mol / L, stir and extract in 80°C water bath for 2h. The extract was centrifuged to separate the extract and the solid, and the solid was washed twice with saturated n-butanol, combined with the extract, and washed with saturated Na 2 CO 3 After the aqueous solution is neutralized, it is concentrated to dryness with a rotary evaporator at a temperature lower than 60° C. to obtain an extract containing ginsenoside Rg5.

Embodiment 3

[0031]A kind of extracting method of ginsenoside Rg5: get ginseng root, after it is pulverized, pass through 120 mesh sieves, get 0.5g ginseng powder, add the mixed solvent (5:3:2) of the ethanol of 15 times volume, n-butanol, water , adding hydrochloric acid to make the acid concentration 0.06mol / L, stirring and extracting in a 70°C water bath for 6h. The extract was centrifuged to separate the extract and the solid, and the solid was washed twice with saturated n-butanol, combined with the extract, and washed with saturated Na 2 CO 3 After the aqueous solution is neutralized, it is concentrated to dryness with a rotary evaporator at a temperature lower than 60° C. to obtain an extract containing ginsenoside Rg5.

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Abstract

The invention relates to a method for extracting ginsenoside Rg5. The method comprises the following step: extracting ginseng powder by using an acid as an auxiliary solvent. In the extraction process, one or more of water, alcohols and ketones can be added into the extraction system as the main solvent. According to the method, the ginseng powder is directly used as the raw material. In the extraction process, ginsenoside extraction, oriented hydrolysis and dehydration fusion are completed in one extraction process, thereby directly and efficiently preparing the ginsenoside-Rg5-containing extract. The method is simple to operate, and has the characteristics of high extraction yield and mild experimental conditions.

Description

technical field [0001] The invention relates to the field of extraction of active ingredients of traditional Chinese medicines, in particular to a method for extracting ginsenoside Rg5, more specifically, to a method for directly extracting secondary ginsenoside Rg5 from ginseng powder. Background technique [0002] Ginsenoside is the most representative main active ingredient of ginseng, which exists in ginseng plants such as ginseng, American ginseng, notoginseng, bamboo ginseng, etc., and is divided into protopanaxadiol group saponins, protopanaxatriol group saponins and olean fruit acid saponins. Protopanaxadiol group saponins mainly include ginsenosides Rb1, Rb2, Rb3, Rc and Rd; protopanaxatriol group saponins mainly include ginsenosides Re and Rg1; oleanolic acid saponins mainly include ginsenoside Ro. A large number of studies have shown that the secondary glycosides obtained by glycosyl modification of glycoside natural compounds show better body absorption capacity...

Claims

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Application Information

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IPC IPC(8): C07J17/00
CPCC07J17/005
Inventor 成乐琴郭丹丹李玲甘凤琴
Owner JILIN PROVINCE CAISENREN BIO TECH CO LTD
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