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A compound prescription of traditional Chinese medicine effective components with antidepressant effect

An effective component and antidepressant technology, applied in the field of traditional Chinese medicine, can solve problems such as unsatisfactory effects, and achieve the effects of strong drug efficacy, cost saving, and small dosage.

Active Publication Date: 2019-11-05
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine mostly uses drugs that promote gastrointestinal motility, but the effect is not ideal. In recent years, traditional Chinese medicine has gained rich experience and good curative effect in the treatment of this disease. Chinese medicine has become a new research direction and goal for the treatment of depression.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with specific embodiments, but this should not be interpreted as the scope of the above-mentioned themes of the present invention being limited to the following embodiments, and all technologies realized based on the above-mentioned contents of the present invention all belong to the scope of the present invention.

[0023] 1 Experimental materials.

[0024] 1.1 Experimental cell lines.

[0025] Human bone marrow neuroblastoma cell line SH-SY5Y (purchased from Cell Resource Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences).

[0026] 1.2 Medicinal materials and reagents.

[0027] Licorice and Rhizoma Cyperi (both provided by Liaoning China Resources Benxi Sanyao Co., Ltd.); DMEM / F12 medium (GIBCO, USA); fetal calf serum (FCS) (Hangzhou Sijiqing Bioengineering Materials Co., Ltd.); water is ultrapure water.

[0028] 1.3 Instruments and equipment.

[0029] US ...

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PUM

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Abstract

The invention provides a Chinese herbal medicine active constituent compound with the anti-depression effect.The Chinese herbal medicine active constituent compound is prepared from licorice active constituents and a rhizoma cyperi active constituent; the licorice active constituents comprise a glycyrrhiza polysaccharide extract and a licorice triterpene extract, and a rhizoma cyperi volatile oil extract is adopted as the rhizoma cyperi active constituent, wherein the preferable weight ratio of the glycyrrhiza polysaccharide extract to the licorice triterpene extract to the rhizoma cyperi volatile oil extract is 4.4328:1.6028:1.The Chinese herbal medicine active constituent compound can be applied to development of a new clinical anti-depression drug by adding auxiliary materials and carriers acceptable in pharmacy.According to the Chinese herbal medicine active constituent compound with the anti-depression effect, the efficient anti-depression Chinese herbal medicine active constituent compound is obtained through compatibility of the licorice active constituents and the rhizoma cyperi active constituent, a foundation is laid for development of the new anti-depression drug, and the defects that in traditional Chinese herbal medicine compatibility, the active constituents are not clear, and the treatment effect is undefined due to the fact that the quality cannot be controlled are overcome.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a compound prescription of effective components of traditional Chinese medicine with antidepressant effect. Background technique [0002] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. It can be seen clinically that the mood is not commensurate with the situation. The depression of mood can range from gloomy to distraught, low self-esteem and depression, even pessimistic world-weariness, and there may be suicide attempts or behaviors; even stupor; some cases have obvious anxiety and motor agitation, Seriously endanger human health. [0003] The pathogenesis of depression is complex, and there are many causes involved. Fatigue, improper diet, and mental factors can all lead to autonomic dysfunction, gastrointestinal motility disorders, abnormal gastrointes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61P25/24
CPCA61K36/484A61K36/8905A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 孟宪生王帅包永睿张丽敏李天娇
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE