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Targeting antitumor drug using magnetic micro-nano material to destroy tumor blood vessels under driving of alternating magnetic field or radio frequency

A technology of micro-nano materials and alternating magnetic field, which is applied in the field of medicine, can solve the problems of restricting popularization and use, and achieve the effect of avoiding accumulation embolism and avoiding injury

Active Publication Date: 2016-06-08
赤峰福纳康生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing tumor vascular blocking agents have relatively serious side effects, such as zibuxostat, CA-1P and MPC-6827 and other phase I / II clinical trials have reported cardiovascular adverse reactions such as hypertension, tachycardia, etc. Tachycardia, bradyarrhythmia, atrial fibrillation, myocardial infarction, these adverse reactions limit its clinical application

Method used

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  • Targeting antitumor drug using magnetic micro-nano material to destroy tumor blood vessels under driving of alternating magnetic field or radio frequency
  • Targeting antitumor drug using magnetic micro-nano material to destroy tumor blood vessels under driving of alternating magnetic field or radio frequency
  • Targeting antitumor drug using magnetic micro-nano material to destroy tumor blood vessels under driving of alternating magnetic field or radio frequency

Examples

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Embodiment 1

[0051] Embodiment 1, with NaGdF 4 Magnetic micro-nano material as the main magnetic metal material is used as a tumor blood vessel blocking agent

[0052] 1. Material preparation:

[0053] The following examples take common up-conversion magnetic nanoparticles as an example, and the nanomaterial with all the properties described in the present invention is NaGdF 4 : Yb, Er citrate modified water-soluble nanoparticles. Its preparation method refers to the literature (Adv. Mater. 2010, 22, 3266; J. Am. Chem. Soc., 2013, 135, 18920; Journal of Fluorine Chemistry 144 (2012) 157). Since citric acid has a water-soluble functional group, it is negatively charged after ionization in water, so the above-mentioned NaGdF 4 :Yb,Er citrate-modified water-soluble nanoparticles also exhibit electronegativity in water.

[0054] figure 1 This is the TEM photo of the up-conversion material, the particle size is about 60-70nm, and the surface of the material is rough and not smooth; figur...

Embodiment 2

[0059] Example 2. With Gd 2 o 3 Magnetic micro-nano material as the main magnetic metal material is used as a tumor blood vessel blocking agent

[0060] The magnetic material used in this embodiment possesses all the properties described in the present invention are commercially available Gd 2 o 3 As the main material (CAS No. 12064-62-9), after SiO 2 Water soluble coating is obtained. Such as Figure 7 Shown, Gd 2 o 3 SiO 2 The TEM photo of the material shows that the particle size is about 70nm, and the surface of the material has many angular structures. According to the in vivo experiment method described in Example 1, the Gd concentration of 20mg / ml was injected through the tail vein 2 o 3 SiO 2 150 μl of aqueous solution was injected into tumor-bearing mice, and then irradiated for 30 minutes with radio frequency at 11 MHz after injection for 15 minutes to 30 minutes. After 1 hour of treatment, the Figure 8 As shown, the tumor site was obviously necrotic, an...

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Abstract

The present invention discloses a novel use of a magnetic micro-nano material. The new use is application of the magnetic micro-nano material in manufacture of a targeting tumor treatment drug, the magnetic micro-nano material has all the following properties: (1) the magnetic micro-nano material is magnetic, sol that the magnetic micro-nano material can produce mechanical destructive effects on tumor blood vessel endothelial cells under driving of an alternating magnetic field or radio frequency; (2) the magnetic micro-nano material has a hydrophilic surface; (3) the magnetic micro-nano material has certain electronegativity on surface; and (4) the particle size range of the magnetic micro-nano material is 10-500nm, so that the magnetic micro-nano material has rigidity (namely, is not easy to deform). The magnetic micro-nano material can be specifically gathered and retained in tumor blood vessel parts by EPR effect after intravenous injection, and the mechanical destructive effects produced under driving of the alternating magnetic field or radio frequency can act on the tumor blood vessel endothelial cells highly selectively to further destroy tumor blood vessels to lead to tumor rapid necrosis and achieve the efficient tumor targeting treatment purpose.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a method of using magnetic micro-nano materials driven by an alternating magnetic field or radio frequency as a tumor blood vessel blocking agent for cancer treatment. Background technique [0002] In recent years, the morbidity and mortality of cancer have been on the rise, which has posed a serious threat to human health and life. According to the cancer survey report, about 7.6 million people died of cancer in the world in 2007. By 2020, the annual number of cancer deaths in the world will will double. The three traditional treatment methods of surgery, radiotherapy, and chemotherapy all have some limitations. Therefore, the difficult problem that needs to be solved urgently is to develop a fast, efficient, and less toxic and side effect tumor-targeted therapy technology. [0003] With the progress of cancer research, people gradually realize that tumor angiogenesis plays a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61P35/00
CPCA61K9/14A61K41/00
Inventor 王春儒甄明明邹头君舒春英王太山
Owner 赤峰福纳康生物技术有限公司
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