A kind of crystallization tank for isepamicin sulfate

Abstract

The invention discloses a crystallization tank for isepamicin sulfate, comprising a motor, a pressure gauge, a temperature gauge, a feeding pipe, an emptying pipe, an upper head, a tank body, a stirring shaft, a stirring paddle, a jacket, and a jacket Water inlet pipe, jacket outlet pipe, lower head, outlet pipe, anti-blocking eddy current device. The added anti-blocking vortex device is easy to install, and the material can generate vortex at the bottom of the crystallization tank under the drive of the stirring paddle, which can obviously improve the flow of the material at the bottom of the crystallization tank and reduce the generation of large crystals; the anti-blocking after surface treatment The vortex blocking device further improves the smoothness of the surface and reduces the friction coefficient, thereby further reducing the possibility of crystallized particles depositing at the bottom of the tank. The use of the crystallization tank not only saves time and labor, but also improves the purity and crystallization yield of crystallization products.

Description

technical field [0001] The invention relates to the technical field of crystallization equipment, in particular to a crystallization tank for isopamicin sulfate with an anti-blocking eddy current device. Background technique [0002] Isepamicin sulfate is an aminoglycoside antibiotic. Generally, gentamicin B is used as the starting material, and the crude product of isopamicin sulfate is obtained through steps such as synthesis and hydrolysis. In order to further improve its purity, a resin layer is usually selected. by precipitation or crystallization. Compared with resin chromatography, crystallization has the advantages of high production efficiency and simple operation. [0003] Crystallization is a common purification process in pharmaceutical and chemical production. Crystallization is often carried out in crystallization tanks. Crystallization needs to go through the crystal growth process to make the crystal nuclei grow slowly. During the crystallization process of...

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Problems solved by technology

During the crystallization process of isopamicin sulfate, since the stirring of the crystallization tank cannot be placed very low, there is still a certain vertical distance between the stirring paddle and the bottom of the tank, resulting in the flow velocity of the fluid at the bottom of the tank being much slower than that of the upper fluid , in the crystal growth process, when the proportion of nucleated grains is relatively large, many grains will often be deposited at the bottom of the tank. As the crystallization proceeds, hard agglomerates will gradually form, which will block the discharge port. Not only does it bring a lot of inconvenience to the subsequent filtration process, but also because of the formation of massive crystals, the mother liquor and impurities will inevitably be trapped in the middle of the massive crystals, which will affect the purity of the crystallized product

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