Biopharmaceutical pressurization filtration system

Abstract

The invention discloses a biopharmaceutical pressurization filtration system, and belongs to the technical field of biological pharmacy. The biopharmaceutical pressurization filtration system comprises a filter; a liquid discharge pipeline and a liquid feeding pump for conveying an extract liquid are connected to the filter; the liquid discharge pipeline is connected to the liquid feeding pump through a circulating pipeline to form a loop; a first power gas source is connected to the top of the filter, and the pressure of the first power gas source is less than or equal to 0.5 MPa; filter leaves are arranged in the filter and driven by a plurality of cylinders in a coordination manner; the cylinders are connected to a gas storage tank respectively; a second power gas source is connected to the gas storage tank, and the pressure of the second power gas source is less than or equal to 0.8 MPa. The biopharmaceutical pressurization filtration system is mainly used for solving the technical problems of easy blockage of filter equipment and heavy influence on the filtration efficiency; pressure gas is supplied into the filter equipment in an automatic pressurization manner, and an automatic clearing effect is realized and the efficiency and the quality of filtration are ensured.

Description

technical field

[0001] The invention relates to the technical field of biopharmaceuticals, in particular to the filtration technology of biopharmaceutical extracts. Background technique

[0002] In the purification and extraction of biopharmaceuticals, steps such as filtering the extract, concentration, and ion exchange chromatography are generally required. The filtration of the extract is a necessary step before ion exchange chromatography, and it is also the most important and time-consuming step. At present, the traditional filtration equipment has a series of problems such as the decrease of the pressure difference of the pressurized filter, the difficulty of forming cakes, the increase of the solid particle content of the filtrate, and the increase of product moisture due to the presence of impurities in the filtrate, which eventually lead to Filtration period is extended, product quality is reduced, and in severe cases, filter residues will accumulate, making the fil...

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