Application of SYK as hepatic fibrosis/cirrhosis therapeutic target

A liver fibrosis and therapeutic target technology, applied in gene therapy, medical preparations containing active ingredients, digestive system, etc., can solve problems such as lack of SYK

Active Publication Date: 2016-06-15
洪健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, no experimental research results have shown that SYK is related to liver fibrosis / cirrhosis, and there is no relevant experimental data to prove that SYK can be used as a therapeutic target for liver fibrosis / cirrhosis

Method used

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  • Application of SYK as hepatic fibrosis/cirrhosis therapeutic target
  • Application of SYK as hepatic fibrosis/cirrhosis therapeutic target
  • Application of SYK as hepatic fibrosis/cirrhosis therapeutic target

Examples

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Embodiment Construction

[0017] The technical solution of the present invention will be further described below in combination with experiments.

[0018] Effects of HBV or HCV on SYK Expression in Hepatocytes or Liver Tissues

[0019] The hepatic cells Huh7.5.1 susceptible to HCV virus infection were selected and infected with HCV virus replicon JFH1, and real-time quantitative PCR (qRT-PCR) and Western blot were used to detect the effects of HCV on the levels of SYK mRNA and protein in the cells, respectively. Immunohistochemical (IHC) method was used to detect human HBV-associated liver fibrosis tissue, normal non-HBV / HCV infected normal liver fibrosis tissue (derived from the paratumoral liver tissue of human hepatic hemangioma), and compare the fibrosis liver tissue Compared with the expression of SYK protein in normal liver tissue ( figure 1 ).

[0020] from figure 1 It can be seen from the above that after hepatitis C virus infection of liver cells, the expression of SYK mRNA and protein leve...

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Abstract

The invention discloses an application of SYK as a hepatic fibrosis / cirrhosis therapeutic target. A test proves that expression of the SYK is increased during a hepatic fibrosis / cirrhosis process, wherein the hepatic fibrosis process is accelerated by promoting activation on hepatic stellate cells. By means of an SYK inhibitor or interference on the expression of the SYK gene, the hepatic fibrosis / cirrhosis process can be retarded effectively, thereby achieving excellent treatment effects.

Description

technical field [0001] The invention relates to a therapeutic target for liver fibrosis / cirrhosis. Background technique [0002] Liver fibrosis / cirrhosis is a major global health problem. Hepatic fibrosis is a necessary stage for a variety of chronic liver diseases to develop into cirrhosis. When the liver is chronically damaged, the secretion and degradation of extracellular matrix in the liver are unbalanced, resulting in excessive or abnormal collagen fiber deposition in the gaps of liver cells. Liver fibrosis is a pathological change in the early stage of liver cirrhosis. The structure of the liver changes, the supply of liver cells is affected, and the liver function is gradually lost. If liver fibrosis is not treated in time, 25%-40% of them will eventually develop into cirrhosis or even liver cancer, causing liver failure and directly or indirectly leading to the death of the patient. [0003] Liver fibrosis is a compensatory repair reaction, which is a chronic and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K31/7088A61K45/00A61P1/16G01N33/68A61K31/675A61K31/5383
CPCA61K48/00A61K31/5383A61K31/506A61K31/5377A61K31/713A61K38/005A61P1/16C12N15/65
Inventor 洪健
Owner 洪健
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