Application of SYK as hepatic fibrosis/cirrhosis therapeutic target
A liver fibrosis and therapeutic target technology, applied in gene therapy, medical preparations containing active ingredients, digestive system, etc., can solve problems such as lack of SYK
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[0017] The technical solution of the present invention will be further described below in combination with experiments.
[0018] Effects of HBV or HCV on SYK Expression in Hepatocytes or Liver Tissues
[0019] The hepatic cells Huh7.5.1 susceptible to HCV virus infection were selected and infected with HCV virus replicon JFH1, and real-time quantitative PCR (qRT-PCR) and Western blot were used to detect the effects of HCV on the levels of SYK mRNA and protein in the cells, respectively. Immunohistochemical (IHC) method was used to detect human HBV-associated liver fibrosis tissue, normal non-HBV / HCV infected normal liver fibrosis tissue (derived from the paratumoral liver tissue of human hepatic hemangioma), and compare the fibrosis liver tissue Compared with the expression of SYK protein in normal liver tissue ( figure 1 ).
[0020] from figure 1 It can be seen from the above that after hepatitis C virus infection of liver cells, the expression of SYK mRNA and protein leve...
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