Chinese medicinal composition for preventing and treating senile dementia

A technology for senile dementia and a composition, applied in the field of medicine, can solve the problems of complex pathogenesis and inability to achieve therapeutic effects, and achieve the effects of reducing the types of drugs, reducing the types of drugs, and easy quality detection and control.

Inactive Publication Date: 2016-06-22
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex pathogenesis of senile dementia involving multiple signaling pathways, although single-targeted drugs can improve or alleviate the symptoms of patients to a certain extent, they cannot achieve a good therapeutic effect

Method used

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  • Chinese medicinal composition for preventing and treating senile dementia
  • Chinese medicinal composition for preventing and treating senile dementia
  • Chinese medicinal composition for preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepare CTS according to the following preparation method, the preparation method includes the following steps:

[0035] Step (1), after pulverizing the traditional Chinese medicines of Uncaria, Tangerine Peel, Ophiopogon japonicus, Pinellia, Poria, Ginseng, Fangfeng, Chrysanthemum, Ginger, Licorice and Gypsum respectively, pass through a 60-mesh sieve, and fine powder for subsequent use;

[0036] Step (2), weigh the Chinese medicine fine powder obtained in step (1) according to the following parts by weight: 3 parts of Uncaria, 3 parts of dried tangerine peel, 3 parts of Ophiopogon japonicus, 3 parts of pinellia, 3 parts of Poria cocos, 2 parts of ginseng, 2 parts of Fangfeng 1 part of chrysanthemum, 2 parts of chrysanthemum, 1 part of ginger, 1 part of licorice, 5 parts of gypsum, and mix well to obtain a Chinese medicine mixture;

[0037]Step (3), add water 6 times the weight of the total medicinal materials to the Chinese medicine mixture obtained in step (2), heat ...

Embodiment 2

[0039] Prepare CTS-JF according to the following preparation method, the preparation method includes the following steps:

[0040] Step (1), after pulverizing the Chinese medicines of Uncaria, pinellia, Poria cocos, chrysanthemum, windproof and ginseng respectively, pass through a 60-mesh sieve, and fine powder for subsequent use;

[0041] Step (1), weigh the Chinese medicine fine powder obtained in step (1) according to the following parts by weight: 3 parts of Uncaria, 3 parts of Pinellia, 3 parts of Poria, 2 parts of Ginseng, 2 parts of Fangfeng, 2 parts of Chrysanthemum, mix evenly, Obtain a mixture of Chinese medicines;

[0042] Step (3), add water 6 times the weight of the total medicinal materials to the Chinese medicine mixture obtained in step (2), heat and ultrasonically extract 2 times at 60°C, extract for 1 hour each time, centrifuge at 4000r / min for 30min, and take the supernatant , combined, placed in a 60°C water bath, concentrated and dried to obtain extract. ...

Embodiment 3

[0044] Examining different concentrations of H 2 o 2 Damage to PC12 cells

[0045] 1. Experimental cells

[0046] PC12 cells were purchased from the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, planted in cell culture flasks at an appropriate cell density according to the cell culture procedures, and placed in a constant temperature of 37 ° C, CO 2 Grow in an incubator with a solubility of 5%.

[0047] 2. Main drugs, reagents and instruments

[0048] Hydrogen peroxide: Sigma-Aldrich (Shanghai) Trading Co., Ltd.

[0049] Amyloid beta (Aβ 25-35 ): Sigma Aldrich (Shanghai) Trading Co., Ltd.

[0050] FBS Fetal Bovine Serum: American Invitrogen Life Technologies Co., Ltd.

[0051] DMEM high glucose medium: Invitrogen Life Technologies Co., Ltd.

[0052] Penicillin Sodium for Injection: Shandong Lukang Pharmaceutical Co., Ltd.

[0053] Gentamicin Sulfate: Nanjing Jinling Pharmaceutical Co., Ltd.

[0054] MTT (Tetramethylazazole Salt): N...

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Abstract

The invention belongs to the technical field of medicine, and discloses a Chinese medicinal composition for preventing and treating senile dementia. The Chinese medicinal composition is prepared from the following bulk pharmaceuticals in parts by weight: 2-5 parts of uncaria, 2-5 parts of poria cocos, 2-5 parts of rhizoma pinelliae, 1-3 parts of flos chrysanthemi, 1-3 parts of radix saposhnikoviae and 1-3 parts of radix ginseng. The invention further discloses a preparation method of the Chinese medicinal composition for preventing and treating senile dementia, and application of the Chinese medicinal composition for preventing and treating senile dementia to preparation of medicaments for preventing and treating senile dementia. The inventor performs a simple prescription research on ancient prescription uncaria powder which has a certain curative effect on senile dementia by a modern pharmacological experiment measure. As proved by a pharmacological experiment, the Chinese medicinal composition can improve H2O2 and Abeta25-35 induced PC12 cell injury effect at the same concentration, increases a cell surviving fraction, and has remarkably superior prevention and treatment effects on senile dementia to an ancient prescription.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a traditional Chinese medicine composition for preventing and treating senile dementia. Background technique [0002] Senile dementia (Alzheimer's disease, AD) is an senile degenerative encephalopathy, which is a persistent high-level neurological activity disorder, that is, in the state of no disturbance of consciousness, memory, thinking, analysis and judgment, visuospatial recognition, Emotional obstacles, etc. [0003] Senile dementia is closely related to aging. As the population ages, the incidence of senile dementia also increases. According to Rotterdarm's research results, the annual incidence rate of 65-69-year-olds is 1.4%, 70-74 years old is 3.9%, 75-79 years old is 16.7%, and it increases to 45.4% at 85 years old. Alzheimer's disease is the fourth leading cause of death in the elderly after tumors, heart disease, and capillary disease. It is a serious and degenerati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61P25/28
CPCA61K36/74A61K9/06A61K36/076A61K36/238A61K36/258A61K36/287A61K36/8888A61K2236/331A61K2236/39A61K2300/00
Inventor 冯锋赵姣姣曲玮柳文媛陈垒
Owner CHINA PHARM UNIV
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