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Traditional Chinese medicine for treating lung cancer patients with malignant pleural effusion in combination with ultrasonic intervention and preparation method

A technology for interventional therapy and pleural effusion. It is used in pharmaceutical formulations, medical preparations containing active ingredients, and blood diseases. It can solve the problems of injury, severe pain, and toxic and side effects in patients with advanced tumors, and achieve no toxic and side effects. The effect of less adverse reactions and simple preparation process

Inactive Publication Date: 2016-06-29
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned methods for the treatment of malignant pleural effusion have achieved certain effects, but almost all therapeutic drugs have side effects in varying degrees, such as the toxic and side effects of chemotherapy drugs, the fever caused by biological immune agents, and the severe side effects caused by sclerosing agents. Pain, etc., all cause certain harm to patients with advanced tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] When the dosage form of the Chinese medicine is a tablet, its preparation method may further comprise the steps:

[0045] The first step is to mix small golden bull grass, golden back loquat flower, hops, Lifei powder, wild holly fruit, coir coir lotus, yellow jingle leaf, bitter mulberry, sharp locust vine and Shuihuman root in proportion, and add 4 to 6 times the amount relative to the mixture Reflux extraction with ethanol with an alcohol concentration of 75% to 85% for 2 to 4 times, each time for 2 to 3 hours, filter, combine the filtrates, recover ethanol, concentrate to a paste with a relative density of 1.33 to 1.35 at 70°C, and set aside;

[0046] The second step is to mix the remaining raw medicinal materials in proportion, add 5 to 7 times the amount of water relative to the mixture, boil for 3 to 5 hours, filter, and concentrate to a paste with a relative density of 1.31 to 1.33 at 70°C;

[0047] The third step is to mix the paste obtained in the first step a...

Embodiment 1

[0057] Embodiment 1: tablet prepared by the present invention

[0058]Take 160g of small golden bull grass, 100g of golden back loquat flower, 320g of hops, 190g of Lifei powder, 300g of wild holly fruit, 250g of coriaceae lotus, 160g of yellow jingle leaf, 290g of bitter radish, 120g of sophora vine, 120g of Shuihuman root, 250g of guava leaf, Hanging golden lamp 310g, black dragon silk 280g, rapeseed 160g, wild alfalfa 120g, ginseng 60g and willow hollow 250g.

[0059] Its preparation method comprises the following steps:

[0060] In the first step, mix small golden bull grass, golden back loquat flower, hops, Lifei powder, wild holly fruit, coir coir lotus, chrysanthemum japonica leaves, bitter mulberry, acacia vine and Shuihuman root in proportion, and add 6 times the alcohol concentration relative to the mixture Reflux extraction with 85% ethanol for 3 times, each time for 3 hours, filter, combine the filtrates, recover ethanol, concentrate to a paste with a relative den...

Embodiment 2

[0065] Embodiment 2: the capsule prepared by the present invention

[0066] Take 190g of small golden bull grass, 70g of golden back loquat flower, 350g of hops, 170g of Lifei powder, 350g of wild holly fruit, 210g of coriaceae lotus, 190g of yellow jingle leaf, 260g of sophora japonica, 150g of sophora vine, 150g of Shuihuman root, 210g of guava leaf, Hanging golden lamp 350g, black dragon silk 260g, rapeseed 190g, wild alfalfa 150g, blessing ginseng 90g and hollow willow 220g.

[0067] Its preparation method comprises the following steps:

[0068] In the first step, mix small golden bull grass, golden back loquat flower, hops, Lifei powder, wild holly fruit and cape lotus according to the stated ratio, add water 6 times relative to the mixture to extract the volatile oil, and use the obtained volatile oil with β- Cyclodextrin inclusion compound, the ratio of volatile oil to β-cyclodextrin is 1:5, stir for 85 minutes, temperature 40°C, get volatile oil inclusion compound, an...

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PUM

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Abstract

The invention provides a traditional Chinese medicine for treating lung cancer patients with malignant pleural effusion in combination with ultrasonic intervention and a preparation method. The traditional Chinese medicine comprises the following raw medicine materials: Chinese violet, przewalsk rhododendron flower, lupulus, scandent hedyotis herb, duhat fruit, aster auriculatus, negundo chastetree leaf, physalis angulata, oxystelma esculentum, unarmed glorybower root, guava leaf, lantern plant calyx, adiantum capillus veneris, cavalerie clearweed herb, wild alfalfa, largeserrate angelica root and willowleaf spiraea herb and root. The traditional Chinese medicine provided by the invention has the beneficial effects of being capable of treating lung cancer patients with malignant pleural effusion in combination with ultrasonic intervention and pleural chemotherapy, convenient to use, capable of obviously improving the curative effect on malignant pleural effusion, free of toxic or side effect, less in adverse reaction and simple in preparation process.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine engineering, in particular to a traditional Chinese medicine combined with ultrasound interventional therapy for malignant lung cancer pleural effusion and a preparation method. Background technique [0002] Neoplastic pleural effusion is also called malignant pleural effusion. In most cases, malignant cells can be found in the pleural effusion. If the pleural effusion is accompanied by metastatic nodules on the mediastinal or pleural surface, whether malignant cells can be found in the pleural effusion , can diagnose malignant pleural effusion. Most of the patients are cachexia in the advanced stage of tumor, such as weight loss, emaciation, fatigue, anemia, etc. About 1 / 3 of the patients with neoplastic pleural effusion have no obvious clinical symptoms, and pleural effusion is only found during physical examination, and the rest 2 / 3 of the patients mainly present with prog...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P35/00A61P7/10
CPCA61K36/69A61K9/2059A61K9/28A61K9/4866A61K36/11A61K36/185A61K36/232A61K36/27A61K36/28A61K36/45A61K36/48A61K36/60A61K36/61A61K36/73A61K36/74A61K36/81A61K36/85A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 杨雪王宏桥于宁马晓静
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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