Application of babybreath isoorientin to preparation of medicine for treating chemical hepatic fibrosis

A technology of different gypsophila and chemical liver, which is applied in the fields of organic chemistry, drug combination, digestive system, etc.

Inactive Publication Date: 2016-07-06
黄权芳
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] Gypsophila elegans Bieb, also known as carnation, xiacao, etc., is a plant of the genus Gypsophila gypsophila. It is a traditional herbal medicine for anti-liver diseases in the Zhuang nationality area of ​​Guangxi. One of its main active ingredients isoorientin -2″-O-α-L-arabinopyranosyl, IOA) to CCl 4 Induced hepatic injury, inflammation, and hepatic fibrosis have not been reported

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  • Application of babybreath isoorientin to preparation of medicine for treating chemical hepatic fibrosis
  • Application of babybreath isoorientin to preparation of medicine for treating chemical hepatic fibrosis
  • Application of babybreath isoorientin to preparation of medicine for treating chemical hepatic fibrosis

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Embodiment Construction

[0017] 1. Preparation of Gypsophila isoorientin

[0018] Extraction method: After crushing 10 kg of dried Gypsophila gypsophila, reflux extraction with 80 L of 75% ethanol for 3 times, combine the 3 ethanol extracts, recover ethanol, and obtain 315.7 g of ethanol extract. Add 630ml of distilled water to the ethanol extract and shake well to form a suspension, and then use petroleum ether, ethyl acetate, and n-butanol to extract sequentially. Extract with 630ml of ethyl acetate, discard the ethyl acetate solution; finally, extract with 630ml of n-butanol, recover n-butanol, and obtain 177.6g of n-butanol extract.

[0019] Purification method: Add D101 macroporous resin to n-butanol extract, first elute with 5 times the amount of water, then elute with 10 times the amount of 90% methanol, recover the methanol, and obtain the crude extract. Dissolve the crude extract in methanol, mix the sample with the same amount of silica gel, load the sample on the silica gel column, and use...

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Abstract

The invention discloses application of a traditional Chinese medicine active ingredient, namely, babybreath isoorientin to preparation of medicine for treating chemical hepatic fibrosis. Treatment of babybreath isoorientin for chemical hepatic fibrosis is researched for the first time. Experiments indicate that babybreath isoorientin can act on multiple links or target points of chemical hepatic fibrosis, lipid peroxidation reactions can be effectively restrained, hepatic tissue pathological damage can be effectively relieved, collagen deposition can be effectively restrained, the activity of matrix metalloproteinase can be effectively adjusted and controlled, and an NF-kappa b signal transduction pathway can be effectively blocked; hepatic injury is obviously relieved, and special advantages are achieved for preventing and treating hepatic injury. Babybreath isoorientin has an obvious restraining effect on hepatic injury caused by carbon tetrachloride and is new medicine for treating chemical hepatic fibrosis, and the new medicine has potential value.

Description

technical field [0001] The present invention relates to the use of the extract of the traditional Chinese medicine Gypsophila gypsophila, in particular the application of Gypsophila gypsophila isoorientin as a raw material in the preparation of a drug for treating chemical liver fibrosis caused by carbon tetrachloride. Background technique [0002] Liver fibrosis is a repair response of the body to chronic liver damage. There are many causes, including viral, autoimmune, drugs or poisons, cholestasis, and metabolic diseases. If not treated in time, it will lead to cirrhosis , liver failure and even hepatocellular carcinoma (HCC). Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM) and collagen (predominantly types I and III). It is now known that excessive ECM deposition changes the normal structure of the liver, disrupts the normal function of the organ, and leads to pathophysiological damage to the liver. Carbon tetrachloride (CCl 4 ) i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P1/16C07D407/04
CPCA61K31/352C07D407/04
Inventor 黄权芳林兴吕淑娟陈永欣黄仁彬张士军韦玲梁春宏
Owner 黄权芳
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