A method of converting oil-soluble nanoparticles into water-soluble nanoparticles

A nanoparticle, oil-soluble technology, applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems affecting the dispersion of nanoparticles and other physical and chemical properties, achieve the retention of physical and chemical properties, and the preparation method is simple and easy Line, overcome the effect of long reaction time

Active Publication Date: 2017-10-24
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the ligand exchange methods currently developed require long-term reactions, which will affect the dispersion and other physical and chemical properties of nanoparticles, so the development of fast ligand exchange methods has certain application value.

Method used

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  • A method of converting oil-soluble nanoparticles into water-soluble nanoparticles
  • A method of converting oil-soluble nanoparticles into water-soluble nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Dissolve 0.2 g of polyethylene glycol phosphate in 3 mL of tetrahydrofuran, and mix this solution with 10 mg / mL of oleic acid-coated Fe 3 o 4 The toluene solution of nanoparticles was mixed, and 5 mL of ether was added to the above solution, and stirred for 2 min. Add 10mL of deionized water to the above solution, stir for 10min and let it stand for 10min, then use a separatory funnel to separate the liquid, take the lower layer solution and perform rotary evaporation to remove the organic solvent to obtain a water-soluble Fe 3 o 4 Nanoparticle solution, add 10mL ethanol to this solution, centrifuge and vacuum dry to obtain water-soluble Fe 3 o 4 Nanoparticle powder.

example 2

[0025] Dissolve 0.2 g of polyethylene glycol phosphate in 5 mL of tetrahydrofuran, and mix this solution with 10 mg / mL of oleic acid-coated NaYF 4 : Yb, Er nanoparticles n-hexane solution mixed, 10mL of ether was added to the above solution, stirred for 2min. Add 10 mL of deionized water to the above solution, stir for 3 minutes and let it stand for 10 minutes, then use a separatory funnel to separate the liquid, take the lower layer solution and perform rotary evaporation to remove the organic solvent to obtain water-soluble NaYF 4 : Yb, Er nanoparticle solution, add 10mL ethanol to this solution, obtain water-soluble NaYF after centrifugal separation, vacuum drying 4 : Yb, Er nanoparticle powder.

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Abstract

The invention provides a method for converting oil-soluble nano-particles into water-soluble nano-particles. The method comprises the following steps: (1) dispersing the oil-soluble nano-particles in a weak polar solvent; (2) adding a tetrahydrofuran solution of polyethylene glycol phosphate into oil-soluble nano-particle dispersion liquid; (3), adding a proper amount of a medium-polarity solvent into the solution obtained in the step (2); (4) adding a proper amount of water into the solution obtained in the step (3); and (5) stirring the mixed solution obtained in the step (4) for 3-10 minutes, then separating the liquid by use of a liquid separation hopper, taking the lower layer, and performing rotary evaporation on the lower layer so as to remove an organic solvent, thereby obtaining the water-soluble nano-particles. The method is simple in operation, short in time, low in cost, good in repeatability and high in efficiency, is capable of effectively converting nanoparticles coated with oleic acid into the water-soluble nano-particles, and has universality and promotional value.

Description

technical field [0001] The invention relates to a method for modifying the surface of nanoparticles, in particular to a method for converting oil-soluble nanoparticles into water-soluble nanoparticles, and belongs to the field of nanoparticle preparation. Background technique [0002] At present, there are many methods for preparing nanomaterials. Among them, in order to obtain monodisperse nanoparticles with controllable size and shape, researchers usually add long-chain surfactant molecules such as oleic acid (or oleylamine) to realize the controllable synthesis of nanoparticles. However, the nanoparticles prepared by this method are oil-soluble, poor in water solubility and biocompatibility, which limit their application in biomedicine and other fields. In order to expand the application of oil-soluble nanoparticles in the biomedical field, it is necessary to choose a suitable method for surface modification to make them water-soluble. At present, the surface modificati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09C3/10C09C3/08C09C1/24C09K11/85C09K11/02B82Y30/00
CPCB82Y30/00C01P2004/61C01P2006/22C09C1/24C09C3/006C09C3/10C09K11/025C09K11/7773
Inventor 左芳秦振立李欣华
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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