Probiotics toothpaste composition capable of improving health of oral cavity

A technology of probiotics and compositions, applied in the field of probiotics toothpaste compositions, can solve the problems of reduced effect of oral care products, inattentiveness to the growth and reproduction of probiotics, etc. Effect

Active Publication Date: 2016-07-20
本护(深圳)投资有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, probiotics have been used to adjust the bacterial phase of oral microorganisms, so that oral probiotics are dominant and pathogenic bacteria are reduced to achieve the purpose of oral health care. The required carbon source leads to ...

Method used

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  • Probiotics toothpaste composition capable of improving health of oral cavity
  • Probiotics toothpaste composition capable of improving health of oral cavity
  • Probiotics toothpaste composition capable of improving health of oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] In a 10-liter esterification reaction kettle with a condenser and a water separator, 5 kg of toluene and 4.48 kg of linear octylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=8, n= 210), 0.52 kg of phthalic anhydride, stirred at a stirring speed of 150 rpm for 30 minutes to make linear octylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=8, n=210) and phthalic anhydride are fully dissolved in toluene; then add 0.05 kg of p-toluenesulfonic acid, and stir at a stirring speed of 150 rpm for 10 minutes, p-toluenesulfonic acid catalyzes linear octylphenol polyoxygen Ethyl ether (alkylphenol polyoxyethylene ether, R=8, n=210) undergoes an esterification reaction with phthalic anhydride; heat up to 110°C, stir at a stirring speed of 150 rpm, and reflux for 4 hours; Finally remove the water in the water separator, utilize the vacuum pump to remove toluene, cool to room temperature, obtain the diester surfactant, and the diester surfactant ...

Embodiment 2

[0060] In a 10-liter esterification reaction kettle with a condenser and a water separator, 5 kg of toluene and 4.92 kg of isooctylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=12, n=500 ), 0.08 kg of phthalic anhydride, and stirred at a stirring speed of 150 rpm for 30 minutes to make isooctylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=12, n=500) and o- Fully dissolve phthalic anhydride in toluene; add 0.003 kg of phosphoric acid, and stir for 10 minutes at a stirring speed of 150 rpm, phosphoric acid catalyzes isooctylphenol polyoxyethyl ether (alkylphenol polyoxyethylene ether, R=12 , n=500) and phthalic anhydride to undergo esterification reaction; heat up to 110°C, stir at a stirring speed of 150 rpm, and reflux for 4 hours; finally remove the water in the water separator and use a vacuum pump to remove Toluene is cooled to room temperature to obtain the diester surfactant, and the diester surfactant structure is as follows:

...

Embodiment 3

[0064] In a 10-liter esterification reaction kettle with a condenser and a water separator, 5 kilograms of toluene and 4.85 kilograms of linear dodecylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=18, n=360), 0.15 kg of phthalic anhydride, stirred at a stirring speed of 150 rpm for 30 minutes to make linear dodecylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=18, n=360) and phthalic anhydride are fully dissolved in toluene; then add 0.02 kg of benzenesulfonic acid, and stir at a stirring speed of 150 rpm for 10 minutes, benzenesulfonic acid catalyzes the linear dodecylphenol polyoxygen Ethyl ether (alkylphenol polyoxyethylene ether, R=18, n=360) undergoes an esterification reaction with phthalic anhydride; heat up to 110°C, stir at a stirring speed of 150 rpm, and reflux for 4 hours; Finally remove the water in the water separator, utilize the vacuum pump to remove toluene, cool to room temperature, obtain the diester surfactant, and t...

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Abstract

The invention discloses a probiotics toothpaste composition capable of improving the health of oral cavity. The composition comprises a first toothpaste component and a second toothpaste component; wherein the first toothpaste component comprises probiotics and mannan oligosaccharide, and the second toothpaste component comprises enzymes, mannatide, and a diester type surfactant; and the first toothpaste component and the second toothpaste component are individually packed, and the first toothpaste component and the second toothpaste component are mixed and blended when being used on the teeth. Mannan oligosaccharide and degradation product of mannatide can provide carbon sources for the growth of probiotics, the pathogenic bacteria in oral cavity cannot utilize mannan oligosaccharide, moreover, mannan oligosaccharide can absorb pathogenic bacteria so as to starve the pathogenic bacteria; at the same time, alkaline polypeptide in degradation product of mannatide can cut off glycan chain of cell walls of bacteria; and the diester type surfactant has a strong cleaning and stain-removing performance, and is capable of effectively remove the residual bacterium bodies. After application, the number of pathogenic bacteria especially streptococcus mutans is greatly reduced, and the health of oral cavity is prominently improved.

Description

technical field [0001] The invention belongs to the technical field of daily necessities, in particular to a probiotic toothpaste composition capable of improving oral health. Background technique [0002] Oral microorganisms are composed of bacteria, fungi, viruses, mycoplasma, and protozoa. There are extensive and complex mutual constraints and interdependence between microorganisms and hosts, and they jointly maintain the balance of oral microecology, especially in the gingival sulcus. The selective adhesion and mutual adhesion between bacteria are in local colonization, growth and reproduction, while the host is through the shedding of epithelial cells and the flushing of gingival crevicular fluid, during which antibodies, complement, neutrophils, lysozyme, lactoferrin A variety of antibacterial factors such as proteins restrict the overgrowth of local cells; there are not only mutual promotion mechanisms such as mutual agglutination and mutual provision of nutrients be...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/73A61K8/66A61K8/64A61K8/85A61Q11/00
Inventor 郭宏涛王剑英聂新华林智黄长龙
Owner 本护(深圳)投资有限责任公司
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