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Praziquantel nanoemulsion in situ gel for preventing and treating bilharziasis and preparation method and application thereof

An in-situ gel, schistosomiasis technology, which is applied in the field of preparation of parasitic drugs, can solve the problems of drug non-compliance, short residence time, frequent dosing and the like

Active Publication Date: 2016-08-03
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, the residence time of praziquantel in animals is short, and frequent administration is required to achieve effective prevention and treatment, which will lead to non-compliance of medication.

Method used

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  • Praziquantel nanoemulsion in situ gel for preventing and treating bilharziasis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1, the preparation of praziquantel nanoemulsion:

[0022] Dissolve praziquantel in an amount of 110 mg / g in the oil phase propylene glycol monocaprylate, and ultrasonically dissolve at 37° C. to obtain a mixed oil phase. Thoroughly mix Tween-20 and polyoxyethylene hydrogenated castor oil RH40 at a ratio of 3:1 to obtain an emulsifier. According to the mass ratio of emulsifier and co-emulsifier (2:1), add co-emulsifier polyethylene glycol- 400, stir evenly at room temperature to obtain a mixed emulsifier. Stir and mix 11.5% mixed oil phase and 30% mixed emulsifier for 15 minutes, then add 58.5% distilled water dropwise, and continue stirring for 15 minutes to obtain praziquantel nanoemulsion.

[0023] 2. Preparation of praziquantel nanoemulsion in situ gel:

[0024] Chitosan (0.25-0.35g) was added to 10ml of 0.10mol / L hydrochloric acid, and stirred at room temperature for 24h to obtain a chitosan solution (2.5%-3.5%, w / v). Sodium glycerophosphate is dissolved in deion...

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Abstract

The invention discloses praziquantel nanoemulsion in situ gel for preventing and treating bilharziasis and a preparation method and application thereof. The modern nano preparation technology is applied, firstly, hydrophobic praziquantel is prepared into O / W type nanoemulsion which can be mixed with water in any proportion, secondly, the O / W type nanoemulsion is highly dispersed into hydrophilic reverse gel, and water-based injection which is uniform, transparent, good in stability and nozzle cleaning performance and appropriate in viscosity is prepared. The praziquantel nanoemulsion in situ gel has the advantages that in vivo experiments show that the provided praziquantel nanoemulsion in situ gel has an obvious controlled-release character, the function of preventing and treating bilharziasis can be prolonged, medicinal degradable materials are adopted in the medicine composition, and the problems of irritation and injection site lesions do not exist.

Description

technical field [0001] The invention relates to the technical field of preparation of drugs for preventing and treating parasites, in particular to a praziquantel nanoemulsion in-situ gel for preventing and treating schistosomiasis, a preparation method and application thereof. Background technique [0002] Parasitic diseases are serious health problems for humans and animals living in the tropics or subtropics. Among many parasitic diseases, schistosomiasis is the most common zoonotic disease, which not only affects the health of humans and animals at all times, but also endangers the healthy and sustainable development of life and economy. Therefore, it has always been the focus of parasitic disease prevention and control. According to statistics, about 20 million patients are infected with schistosomiasis every year, and the number of people facing schistosomiasis infection is close to 77.9 million. [0003] Praziquantel (2-cyclohexylformyl-1,2,3,6,7,1ib-hexahydro-4H-pyr...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4985A61P33/12
CPCA61K9/0019A61K9/06A61K9/1075A61K31/4985A61K47/36Y02A50/30
Inventor 李剑勇史彦斌杨亚军刘希望杜文斌
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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