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Injection for preventing phlebothrombosis after orthopedic or surgical operations and preparation method of injection

A technology for surgery and venous thrombosis, which is applied in the field of medicine, can solve the problems of reduced potency of injections and increased content of free sulfate radicals, and achieve the effects of avoiding the reduction of potency of preparations, improving safety, and stabilizing quality

Inactive Publication Date: 2016-08-10
邱阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In view of the above deficiencies, the present invention provides a kind of injection for preventing orthopedics or postoperative venous thrombosis and a preparation method thereof. The injection of the present invention is filled in ampoules. During the packaging process, the potency of the injection solution decreased and the content of free sulfate radicals increased due to high-temperature melting and sealing

Method used

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  • Injection for preventing phlebothrombosis after orthopedic or surgical operations and preparation method of injection
  • Injection for preventing phlebothrombosis after orthopedic or surgical operations and preparation method of injection
  • Injection for preventing phlebothrombosis after orthopedic or surgical operations and preparation method of injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] prescription

[0036]

[0037] Preparation Process

[0038] Step a. Ampoule treatment: the ampoule is washed clean by an ultrasonic bottle washer, sterilized and dried by a tunnel-type sterilization dryer at not less than 290°C, and then transferred to the filling room for use;

[0039] Step b. Preparation: ①. Weigh the prescribed amount of enoxaparin sodium and methionine and dissolve in 70% water for injection, stir to dissolve, adjust the pH value with a pH regulator, after the pH is adjusted, stir and mix evenly;

[0040] ②. Weigh the prescribed amount of Tween-20 and dissolve it in the remaining amount of water for injection, stir and mix well;

[0041] ③. Add the solution in ② to the solution in ①, stir and mix evenly, dilute to full volume with water for injection, sample and test the intermediate product solution, and prepare for potting when it is qualified;

[0042] Step c. Filling: the solution is filtered to the filling room, and filled in a neutral borosilicate glass ...

Embodiment 2

[0046] prescription

[0047]

[0048] Preparation process: same as Example 1

Embodiment 3

[0050] prescription

[0051]

[0052] Preparation process: same as Example 1

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to an injection for preventing venous thrombosis after orthopedic or surgical operations and a preparation method thereof; the active ingredients are mainly enoxaparin sodium, Tween-20, methionine, a pH regulator and Composition of water for injection. The preparation of the present invention is filled with neutral borosilicate glass ampoules, which can effectively avoid the risk of lowering the potency of the preparation and increasing the content of free sulfate radicals during the high-temperature melting and sealing process of the ampoule; at the same time, the preparation of the present invention is filled with neutral borosilicate glass ampoules. packaging, can greatly save the cost of packaging materials and improve the production capacity of the product; the preparation of the present invention has stable quality and simple process. security.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an injection for preventing venous thrombosis after orthopedics or surgery and a preparation method thereof. Background technique [0002] Venous thrombosis refers to a disease in which acute non-suppurative inflammation of the vein occurs under conditions of slow venous blood flow, hypercoagulable blood and vascular intima injury, and secondary thrombosis. The vast majority of venous thrombosis occurs in the deep veins of the pelvis and lower extremities, and is more common in patients with fractures, trauma, and after surgery. [0003] Due to the risk of injury to the patient’s venous wall during major orthopedic and surgical operations, the patient’s venous blood flow slowly stagnates during the early postoperative rehabilitation period and the blood is in a hypercoagulable state. If effective preventive measures are not taken at this time, it will be easy Venous thrombo...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/727A61K47/26A61K47/20A61P9/10A61P7/02B65B3/00
CPCA61K9/08A61K9/0019A61K31/727A61K47/183A61K47/26B65B3/003
Inventor 邱阳
Owner 邱阳
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