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A kind of aureomycin microcapsule premix and preparation method thereof

A technology of premix and chlortetracycline, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations, can solve the problems of prolonging the effective time of chlortetracycline, reducing the number of administrations, and instability of chlortetracycline, etc. Effective action time, reducing the number of administrations, and solving unstable effects

Active Publication Date: 2018-09-14
GUANGZHOU CARDLO BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of chlortetracycline microcapsule premix, to eliminate the influence of chlortetracycline bitterness on palatability, solve the problem that chlortetracycline is unstable and easily hydrolyzed in gastric juice, prolong the period of aureomycin Effective action time of the hormone in the intestinal tract, reducing the number of administrations

Method used

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  • A kind of aureomycin microcapsule premix and preparation method thereof
  • A kind of aureomycin microcapsule premix and preparation method thereof
  • A kind of aureomycin microcapsule premix and preparation method thereof

Examples

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experiment example 1

[0029] The aureomycin microcapsule premix of the embodiment of the present invention 1 comprises the raw material of following parts by weight:

[0030] 25 parts of aureomycin hydrochloride, 16 parts of sucrose ester, 50 parts of capsule wall polymer, 6 parts of xanthan gum, 10 parts of polyvinylpyrrolidone and 60 parts of water;

[0031] Wherein, the sucrose esters include 10 parts of sucrose esters with an HLB value of 4 and 6 parts of sucrose esters with an HLB value of 12; The ester is composed of a weight ratio of 1:2.5; the solvent of the capsule wall polymer is ethyl acetate, and the amount of ethyl acetate is 1.5 times the weight of the capsule wall polymer;

[0032] Preparation:

[0033] (1) Take the capsule wall polymer, add ethyl acetate and stir to dissolve, and add sucrose ester with an HLB value of 4, stir and disperse evenly to obtain an oil phase solution;

[0034] (2) Take aureomycin hydrochloride, add 1 / 3 amount of water, stir evenly, and then disperse in t...

experiment example 2

[0039] The chlortetracycline microcapsule premix of embodiment 2 of the present invention comprises the raw material of following parts by weight:

[0040] 15 parts of aureomycin hydrochloride, 10 parts of sucrose ester, 40 parts of capsule wall polymer, 4 parts of xanthan gum, 8 parts of polyvinylpyrrolidone and 50 parts of water;

[0041]Wherein, the sucrose esters include 6 parts of sucrose esters with an HLB value of 4 and 4 parts of sucrose esters with an HLB value of 12; The ester is composed of a weight ratio of 1:2.5; the solvent of the capsule wall polymer is ethyl acetate, and the amount of ethyl acetate is 1.5 times the weight of the capsule wall polymer;

[0042] The preparation method refers to Example 1.

experiment example 3

[0044] The aureomycin microcapsule premix of embodiment 3 of the present invention comprises the raw material of following parts by weight:

[0045] 30 parts of aureomycin hydrochloride, 24 parts of sucrose ester, 60 parts of capsule wall polymer, 8 parts of xanthan gum, 12 parts of polyvinylpyrrolidone and 70 parts of water;

[0046] Wherein, the sucrose esters include 14 parts of sucrose esters with an HLB value of 4 and 10 parts of sucrose esters with an HLB value of 12; The ester is composed of a weight ratio of 1:2.5; the solvent of the capsule wall polymer is ethyl acetate, and the amount of ethyl acetate is 1.5 times the weight of the capsule wall polymer;

[0047] The preparation method refers to Example 1.

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Abstract

The invention belongs to the field of feed additives, and particularly relates to an aureomycin micro-capsule premix and a preparation method thereof. The premix is prepared from, by weight, 15-30 parts of chlortetracycline hydrochloride, 10-24 parts of sucrose ester, 40-60 parts of a capsule wall polymer, 4-8 parts of xanthan gum, 8-12 parts of polyvinylpyrrolidone and 50-70 parts of water, wherein sucrose ester includes 5-12 parts of sucrose ester with the HLB value of 3-5 and 5-12 parts of sucrose ester with the HLB value of 12-14, and the capsule wall polymer is prepared from a poly(lactide-glycolide acid) copolymer and polyvinyl alcohol acetic acid polyethylene terephthalate at the weight ratio of (0.5-2):(2-4). Aureomycin micro-capsules are prepared with a W / O / W duplicate-latices method, the obtained aureomycin micro-capsules are high in drug loading capacity and have good light and heat stability and slow release performance, aureomycin can be prevented from being dissolved out or damaged in the stomach and can be slowly released after entering the intestinal tract, and thus the drug function is improved.

Description

technical field [0001] The invention belongs to the field of feed additives, and in particular relates to a chlortetracycline microcapsule premix and a preparation method thereof. Background technique [0002] Chlortetracycline (Chlortetracycline), also known as chlortetracycline, referred to as CTC, is the first discovered tetracycline antibiotics. Chlortetracycline has a broad antibacterial spectrum, and has inhibitory effects on Gram-positive and negative bacteria, mycoplasma, chlamydia, spirochetes, rickettsia, amoeba, etc. The excellent antibacterial properties of aureomycin have attracted much attention in feed additives. Feed grade chlortetracycline is chlortetracycline calcium salt, and chlortetracycline calcium salt itself does not have biological activity. Only when it is converted into chlortetracycline hydrochloride under the action of animal stomach acid can it be absorbed and utilized by the animal body, but chlortetracycline hydrochloride Chlortetracycline i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/34A61K47/32A61K31/65A61P31/04
CPCA61K9/5026A61K9/5031A61K9/5089A61K31/65
Inventor 徐怀义
Owner GUANGZHOU CARDLO BIOCHEM TECH
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