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Preparation method of medicine for resisting cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and drugs, which is applied in the field of preparation of anti-cardiovascular and cerebrovascular disease drugs, can solve the problems of inconspicuous clinical effects, and achieve the effect of normal physiological toxicity and inhibition of thrombus formation

Inactive Publication Date: 2016-08-31
张阳
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

KIF is an oxypropionitrile compound, and pharmacological experiments have confirmed that it has a certain effect on treating cardiovascular and cerebrovascular diseases; but the clinical effect is not obvious

Method used

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  • Preparation method of medicine for resisting cardiovascular and cerebrovascular diseases
  • Preparation method of medicine for resisting cardiovascular and cerebrovascular diseases
  • Preparation method of medicine for resisting cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0014] The present invention will be further described below in conjunction with embodiment; The chemical structural formula of the compound involved in this embodiment is as follows;

[0015]

[0016] Under a nitrogen atmosphere, equimolar tert-butylphenyl carbonate and allyl diglycol dicarbonate were dissolved in 10 mL of methylene chloride, and after stirring, 0.2 mol% of pyridoxine and 0.0015 mol% of catalyst bis( Dichloromethane solution of bis(trimethylsilyl)amine zinc, sealed at 55°C and reacted for 30 hours, terminated with glacial acetic acid, precipitated in glacial ether, filtered and vacuum-dried to obtain carbonate polymer.

[0017] Add the compound into the buffer solution dispersed with the carbonate polymer, stir magnetically for half an hour, then add sucrose to prepare drug suspensions with drug concentrations of 1wt%, 2wt%, and 5wt%, and set aside.

[0018] Take 30 mice with a body weight of 28 ± 2g, half male and half male; the suspension is administered...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a medicine for resisting cardiovascular and cerebrovascular diseases. The method comprises the following steps: dissolving tert-Butyl phenyl carbonate and diallyl 2,2'-oxydiethyl dicarbonate into dichloromethane in a nitrogen environment; adding an initiator and dichloromethane solution of a catalyst after stirring, carrying out sealing polymerization, terminating reaction by glacial acetic acid, carrying out precipitation in ice diethyl ether, and carrying out filtration and vacuum drying to obtain a carbonate polymer; adding the compound to a buffer solution into which the carbonate polymer is dispersed, and magnetically stirring the buffer solution for half an hour; adding sucrose, and preparing a medicine suspension to obtain the medicine for resisting the cardiovascular and cerebrovascular diseases. The medicine provided by the invention is capable of inhibiting platelet activity and gathering performance and relatively effectively inhibiting thrombus formation, and is free of an effect on normal physiological activity; and the defects of KIF are relatively well overcome, so that the cardiovascular and cerebrovascular diseases can be resisted; and the method has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a preparation method of anti-cardiovascular and cerebrovascular disease drugs. Background technique [0002] The clinical onset of cardiovascular and cerebrovascular diseases is mostly sudden coma, unconsciousness, hemiplegia, crooked mouth and eyes, dysphasia of speech or hemiplegia and other symptoms. Timely application of western medicine is the key to saving patients' lives, such as anti-platelet aggregation, neuroprotection, etc. Drugs, thrombolytic therapy, reducing intracranial pressure and prevention of complications. Among the elderly in China, the incidence rate of cardiovascular and cerebrovascular diseases is as high as 30%. Cardiovascular and cerebrovascular diseases rank first in the cause of death, much higher than the rate of other diseases. Thromboembolism is the most common cardiovascular and cerebrovascular disease. Vascular intima damage, slowed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/277A61K47/34A61P9/00A61P7/02
CPCA61K31/277A61K47/34
Inventor 张阳
Owner 张阳
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