Mannitol injection

A technology of injection and mannitol, which is applied in the fields of drug delivery, plant raw materials, cardiovascular system diseases, etc., can solve the problems of easy crystallization of mannitol injection, delayed rescue time for critically ill patients, and reduced concentration of mannitol liquid. , to achieve the effect of improving rapid cerebral hemorrhage and high intracranial pressure, reducing adverse reactions, and little vascular stimulation

Inactive Publication Date: 2016-09-21
苏远芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the small crystals of mannitol may block the filter screen of the infusion tube, making the flow of the liquid unsmooth, and the concentration of the mannitol transmission liquid after the crystals are filtered is reduced, and the drug effect is reduced
In short, the easy crystallization of mannitol injection has caused a lot of inconvenience to its clinical application.
[0003] When using mannitol injection, when crystals appear, medical staff usually use traditional hot water baths, electric heating platens, electrified warm liquid bags, steam and other heating and dissolving methods to completely dissolve the crystals before use. A lot of inconvenience, especially for critically ill patients to delay the rescue time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The raw materials are taken according to the following weight percentages: 12% of mannitol, 1.3% of jasmine flower extract, 0.8% of Sanqi extract, and water for injection is added to 100%; the mannitol, jasmine flower extract and Sanqi extract are dissolved in an appropriate amount of water for injection Add 0.5% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, mix well, filter, fill and seal, and sterilize at 110°C for 18 minutes.

[0031] The preparation method of above-mentioned jasmine flower extract is as follows:

[0032] 1) Weigh the jasmine flower, add 18 times the weight of the jasmine flower in an ethanol solution with a volume concentration of 60%, adjust the pressure to 180 MPa, and perform ultra-high pressure treatment for 2 minutes to obtain an ultra-high pressure treatment liquid;

[0033] 2) Ultrasonic extraction of the ultra-high pressure treatment solution at a frequency of 60 MHz and a temperatur...

Embodiment 2

[0042] The raw materials are taken according to the following weight percentages: 15% of mannitol, 1.1% of jasmine flower extract, 1.1% of Sanqi extract, and water for injection is added to 100%; the mannitol, jasmine flower extract and Sanqi extract are dissolved in an appropriate amount of water for injection Add 0.5% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, mix well, filter, fill and seal, and sterilize at 110°C for 18 minutes.

[0043] The preparation method of above-mentioned jasmine flower extract is as follows:

[0044] 1) Weigh the jasmine flower, add 16 times the weight of the jasmine flower in an ethanol solution with a volume concentration of 65%, adjust the pressure to 160 MPa, and perform ultra-high pressure treatment for 3 minutes to obtain an ultra-high pressure treatment liquid;

[0045] 2) Ultrasonic extraction of the ultra-high pressure treatment solution at a frequency of 50 MHz and a temperatur...

Embodiment 3

[0054]Get raw materials according to the following weight percentages: 17% of mannitol, 0.8% of jasmine flower extract, 1.3% of Sanqi extract, add water for injection to 100%; dissolve mannitol, jasmine flower extract and Sanqi extract in appropriate amount of water for injection Add 0.5% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, mix well, filter, fill and seal, and sterilize at 110°C for 18 minutes.

[0055] The preparation method of above-mentioned jasmine flower extract is as follows:

[0056] 1) Weigh the jasmine flower, add 15 times the weight of the jasmine flower in an ethanol solution with a volume concentration of 70%, adjust the pressure to 140 MPa, and perform ultra-high pressure treatment for 4 minutes to obtain an ultra-high pressure treatment solution;

[0057] 2) Ultrasonic extraction of the ultra-high pressure treatment solution at a frequency of 30 MHz and a temperature of 60° C. for 20 minutes to ...

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Abstract

The invention relates to the technical field of medicinal preparations, in particular to a mannitol injection. The mannitol injection is prepared from the following raw materials in percentage by weight: 12 to 19 percent of mannitol, 0.5 to 1.3 percent of a jasmine extract, 0.8 to 1.6 percent of a pseudo-ginseng extract, and the balance of injection water, and the total percent is 100. Compared with the prior art, the mannitol injection provided by the invention has a good treatment effect and a good effect on treating high intracranial pressure caused by cerebral hemorrhage, does not crystallize at a low temperature, and is high in use safety and convenient to use clinically; hypersensitivity is avoided; adverse reactions, such as an infusion reaction, are remarkably reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a mannitol injection. Background technique [0002] Mannitol is a kind of hexanehexol, which is an isomer of sorbitol. It is a good diuretic and dehydrating drug. It is used to treat cerebral edema and increased intracranial pressure caused by various reasons. It is also used in other eye-reducing diseases. When internal pressure medicine is ineffective or before intraocular surgery. At 20°C, the solubility of mannitol in water is 1:5.5 (18%), and 20% mannitol injection is a supersaturated solution. When the room temperature is lower than 15°C, mannitol particles are easily produced, and even crystals are precipitated. When the temperature continues to drop, the crystals increase in size and become large columnar and flocculent crystals. If the packaging is a plastic soft bag, it will cause damage and increase the risk of medication. The particles in the man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K36/63A61P9/10A61P9/12A61K31/047
CPCA61K9/08A61K9/0019A61K31/047A61K36/258A61K36/63A61K2236/333
Inventor 苏远芳
Owner 苏远芳
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