3-amino-1-adamantanol production improvement device

A technology of adamantanol and amino, which is applied in the field of 3-amino-1-adamantanol production improvement equipment, can solve the problem of high single impurity content of 3-amino-1-adamantanol, achieve reduction of simple impurity content, The effect of improving quality and increasing content

Inactive Publication Date: 2016-09-21
天津民祥生物医药股份有限公司
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantage that the bubbles produced in the production process of the prior art bring in a lot of caffeine, resulting in too high a single hetero content of 3-amino-1-adamantanol, and provide a 3-amino-1- Improvement device for production of adamantanol

Method used

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Embodiment Construction

[0022] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and preferred embodiments.

[0023] figure 1 Show a kind of production improvement device of 3-amino-1-adamantanol, comprise the reaction liquid storage tank 1, magnetic pump 2 and the reactor 3 that have stirring paddle connected sequentially by catheter; Described reaction liquid An ultrasonic device 4 is provided between the storage tank and the magnetic pump 2; the ultrasonic device includes a box body 41, an ultrasonic vibrating plate 42 arranged inside the box body, and an ultrasonic vibrating plate connected with the ultrasonic vibrating plate arranged in the box Ultrasonic generating device 43 outside the body; the inlet port 44 of the box body is connected to the bottom of the reaction liquid storage tank 4 , and the outlet port 45 is conne...

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Abstract

The invention belongs to the field of chemical production, and particularly relates to a 3-amino-1-adamantanol production improvement device. The 3-amino-1-adamantanol production improvement device comprises a reaction liquid storage tank, a magnetic drive pump, and a reaction kettle provided with a stirring paddle, wherein the reaction liquid storage tank, the magnetic drive pump and the reaction kettle are sequentially connected through a liquid delivery tube; an ultrasound device is arranged between the reaction liquid storage tank and the magnetic drive pump and comprises a box body, an ultrasound concussion board arranged in the box body, and an ultrasound generation device arranged outside the box body and connected with the ultrasound concussion board; an inlet end of the box body is connected with the bottom part of the reaction liquid storage tank, and an outlet end of the box body is connected with the magnetic drive pump. The bottom part of the reaction kettle is connected with an inlet of the reaction liquid storage tank. The ultrasound concussion board of the ultrasound device shocks and breaks bubbles so as to greatly reduce the phenomenon of gas-including liquid, the content of the individual impurity of a finished product of 3-amino-1-adamantanol is reduced to be lower than 0.3%, and the content of the product is improved.

Description

technical field [0001] The invention belongs to the field of chemical production, and in particular relates to a production improvement device for 3-amino-1-adamantanol. Background technique [0002] Since the beginning of the 21st century, the latest diabetes treatment drug dipeptidyl peptidase (DPP-IV) inhibitor has gradually emerged, breaking the monopoly of insulin, sulfonylureas, biguanides and other drugs. Most of these drugs use 3-aminoadamantanol or its derivatives as intermediates. However, the patents of the original research are close to expiration, and there are many applications for imitation one after another. The demand for 3-amino-1-adamantanol as a key raw material is very large. [0003] In the production of 3-amino-1-adamantanol in the prior art, first add concentrated sulfuric acid to the reaction liquid storage tank, and at the same time slowly add amantadine hydrochloride, and pass in frozen water to keep the temperature below 20°C, stir evenly, and sl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/00C07C215/44
CPCC07C213/00
Inventor 刘万里刘彩田许晓勇陈鑫陈瑞香
Owner 天津民祥生物医药股份有限公司
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