3-amino-1-adamantanol production improvement device

Abstract

The invention belongs to the field of chemical production, and particularly relates to a 3-amino-1-adamantanol production improvement device. The 3-amino-1-adamantanol production improvement device comprises a reaction liquid storage tank, a magnetic drive pump, and a reaction kettle provided with a stirring paddle, wherein the reaction liquid storage tank, the magnetic drive pump and the reaction kettle are sequentially connected through a liquid delivery tube; an ultrasound device is arranged between the reaction liquid storage tank and the magnetic drive pump and comprises a box body, an ultrasound concussion board arranged in the box body, and an ultrasound generation device arranged outside the box body and connected with the ultrasound concussion board; an inlet end of the box body is connected with the bottom part of the reaction liquid storage tank, and an outlet end of the box body is connected with the magnetic drive pump. The bottom part of the reaction kettle is connected with an inlet of the reaction liquid storage tank. The ultrasound concussion board of the ultrasound device shocks and breaks bubbles so as to greatly reduce the phenomenon of gas-including liquid, the content of the individual impurity of a finished product of 3-amino-1-adamantanol is reduced to be lower than 0.3%, and the content of the product is improved.

Description

technical field [0001] The invention belongs to the field of chemical production, and in particular relates to a production improvement device for 3-amino-1-adamantanol. Background technique [0002] Since the beginning of the 21st century, the latest diabetes treatment drug dipeptidyl peptidase (DPP-IV) inhibitor has gradually emerged, breaking the monopoly of insulin, sulfonylureas, biguanides and other drugs. Most of these drugs use 3-aminoadamantanol or its derivatives as intermediates. However, the patents of the original research are close to expiration, and there are many applications for imitation one after another. The demand for 3-amino-1-adamantanol as a key raw material is very large. [0003] In the production of 3-amino-1-adamantanol in the prior art, first add concentrated sulfuric acid to the reaction liquid storage tank, and at the same time slowly add amantadine hydrochloride, and pass in frozen water to keep the temperature below 20°C, stir evenly, and sl...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantage that the bubbles produced in the production process of the prior art bring in a lot of caffeine, resulting in too high a single hetero content of 3-amino-1-adamantanol, and provide a 3-amino-1- Improvement device for production of adamantanol

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