Detection method of traditional Chinese medicine pills

A technology of traditional Chinese medicine pills and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of poor observation effect, high taste of medicine, and influence on accuracy, so as to ensure the quality of medicines, clinical efficacy, and drug safety Effect

Active Publication Date: 2016-09-28
九寨沟天然药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bupleurum is used in the prescription, and its main effect is to reconcile Shaoyang, harmonize the stomach, strengthen the body and eliminate evil, but because Bupleurum is a commonly used medicine and used in large quantities, and the production of Bupleurum is limited, the counterfeit product Daye Bupleurum bupleurum has also been used intentionally or unintentionally. Bupleurum bupleurum contains bupleurum toxin and acetylbupleurum toxin, both of which are toxic substances. Poisoning phytotoxicity incidents, so it is necessary to control Daye Bupleurum
"Shandong Pharmaceutical Industry" published the article "Supplement to the Inspection Method of Bupleurum Radix in 2000 Edition of the Chinese Pharmacopoeia" in the fifth issue of Volume 22 in 2003. There are obvious deficiencies: 24 hours of storage, the detection time is too long, which is not conducive to the control of drug production process and drug quality supervision and inspection; because the content of Bupleurum toxin and acetyl Bupleurum toxin is relatively low, the sample is only 2 μl, and the sample volume is too small , which affects the accuracy of the test; because the content of Bupleurum toxin and acetylbupleurum toxin is relatively low, it is not good to observe under ultraviolet light without color development, and the more important thing is the prescription of Xiaochaihu granules. It contains many ingredients and complex ingredients, and other ingredients will cause confusion and interference. Therefore, it is urgent to find a better way to control Dayebupleurum

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1. Character identification:

[0043] This product is a capsule, the content is brown powder; the air is cool, bitter and slightly pungent.

[0044] 2. TLC qualitative identification:

[0045] Qualitative identification of cassia seed and Wangjiangzi: take 3g of this content, add 30ml of methanol, soak for 1 hour, filter, evaporate the filtrate to dryness, add 20ml of water to dissolve the residue, add 2ml of hydrochloric acid, heat on a water bath for 30 minutes, and cool immediately , Extracted twice with ether, 20ml each time, combined the ether solution, evaporated to dryness, added 1ml of chloroform to dissolve the residue, and used it as the test solution. Separately take 0.5g of Semen Cassiae reference medicinal material and Semen Wangjiangnan reference medicinal material respectively, respectively make Semen Cassiae reference medicinal material solution and Semen Wangjiangnan contrast medicinal material solution according to the preparation method of the test s...

Embodiment 2

[0049] 1. Character identification: This product is a capsule, and the content is brown powder; the air is cool, bitter and slightly pungent.

[0050] 2. TLC qualitative identification:

[0051] Qualitative identification of cassia seed and Wangjiangzi: take 3g of this content, add 30ml of methanol, soak for 1 hour, filter, evaporate the filtrate to dryness, add 20ml of water to dissolve the residue, add 2ml of hydrochloric acid, heat on a water bath for 30 minutes, and cool immediately , Extracted twice with ether, 20ml each time, combined the ether solution, evaporated to dryness, added 1ml of chloroform to dissolve the residue, and used it as the test solution. Separately take 0.5g of Semen Cassiae reference medicinal material and Semen Wangjiangnan reference medicinal material respectively, respectively make Semen Cassiae reference medicinal material solution and Semen Wangjiangnan contrast medicinal material solution according to the preparation method of the test solution,...

Embodiment 3

[0055] 1. Character identification: This product is a capsule, and the content is brown powder; the air is cool, bitter and slightly pungent.

[0056] 2. TLC qualitative identification:

[0057] Qualitative identification of cassia seed and Wangjiangzi: take 3g of this content, add 30ml of methanol, soak for 1 hour, filter, evaporate the filtrate to dryness, add 20ml of water to dissolve the residue, add 2ml of hydrochloric acid, heat on a water bath for 30 minutes, and cool immediately , Extracted twice with ether, 20ml each time, combined the ether solution, evaporated to dryness, added 1ml of chloroform to dissolve the residue, and used it as the test solution. Separately take 0.5g of Semen Cassiae reference medicinal material and Semen Wangjiangnan reference medicinal material respectively, respectively make Semen Cassiae reference medicinal material solution and Semen Wangjiangnan contrast medicinal material solution according to the preparation method of the test solutio...

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PUM

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Abstract

The invention discloses a detection method of traditional Chinese medicine pills. The detection method comprises the steps of character detection and thin-layer chromatography qualitative identification, wherein the thin-layer chromatography qualitative identification comprises the qualitative identification of semen cassia and coffee senna seed, the qualitative identification of radix bupleuri and Bupleurum longiradiarum and the qualitative identification of orange osmanthus in the traditional Chinese medicine pills. By virtue of the detection method, the blending of coffee senna seed and Bupleurum longiradiarum in the traditional Chinese medicine pills is effectively controlled, and meanwhile, the traditional Chinese medicine pills contain the components of semen cassia, radix bupleuri and angelica, so that the condition of medicinal materials few medicinal materials are added or even not added is effectively controlled, the quality of medicines is guaranteed, and the medication safety is guaranteed.

Description

technical field [0001] The invention relates to a method for identifying medicinal ingredients, in particular to a method for detecting traditional Chinese medicine pills. Background technique [0002] Xiongdan pill is a traditional Chinese medicine pill recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". Its standard number is WS3-B-0460-90. Mastiff, chrysanthemum, plantain seed (salt), cassia seed, bupleurum, windproof, scutellaria baicalensis, horsetail, coptis powder, menthol, rhubarb, borneol, bear bile, are capsules made of pure traditional Chinese medicine, which have the function of clearing away heat and dissipating heat. Wind, the effect of relieving pain and removing nebula. It is clinically used for the treatment of conjunctival congestion, swelling, pain, embarrassment and tears caused by wind-heat or liver meridian damp-heat. The drug standard was the earliest drug standard formulated b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 钟茂团黎黎何德中温国梁古莉
Owner 九寨沟天然药业股份有限公司
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