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Lacrimal implants

An implant, lacrimal gland technology, applied in the field of lacrimal gland implants, eye implants, can solve problems such as inefficiency, lack of patient compliance or non-localized drug delivery

Active Publication Date: 2016-10-12
MATI THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In areas distinct from ocular therapy, the management of respiratory-related (eg, allergies) and inner ear diseases or disorders often requires repeated artificial digestion or other ingestion of pharmaceuticals (eg, drugs or other therapeutic agents), and will be ineffective due to lack of patient compliance or non-localized drug delivery

Method used

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Examples

Experimental program
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Effect test

experiment example 1

[0243] Figure 46 A lacrimal implant is shown including a notch extending from the proximal end of the second portion of the implant. In the recess, a swellable hydrogel material is arranged. To allow fluid to be taken up by the hydrogel material, the orifices of the notches are left open.

[0244] At 4602 is indicated the hydrogel material and part of the surrounding implant at 30 minutes of hydration. At 4604 is indicated the hydrogel material and part of the surrounding implant at 120 minutes of hydration. At 4606 is indicated the hydrogel material and part of the surrounding implant at 240 minutes of hydration. At 4608 is indicated the hydrogel material and part of the surrounding implant at 1440 minutes of hydration. As shown, the expansion of the hydrogel material causes the surrounding parts of the implant, especially the second part of the implant, to expand outward, such as to the size and shape of the small tube wall, to securely hold the implant. desired positi...

experiment example 2

[0246] Figure 47 A lacrimal implant is shown including a notch extending from the proximal end of the second portion of the implant. In the recess, a swellable hydrogel material is arranged. To allow fluid to be taken up by the hydrogel material, the orifices of the notches are left open.

[0247]In this example, the hydrogel material is constructed and positioned to, when implanted, expand laterally out of the notch and into the ampullary region 4770 to aid in retention of the lacrimal implant within the lacrimal hall. Lateral expansion of the hydrogel material pushes the cap or other protrusion at the proximal end of the first portion flush with the tear hall surface 4772 as shown.

[0248] Examples of sheaths:

[0249] In various ways, the sheath can comprise appropriate shapes and materials to control the migration of drugs or other therapeutic agents from a dissimilar drug insert or implant that includes an integrated drug or other agent. In some examples, the sheath...

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Abstract

Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.

Description

[0001] This divisional application is a divisional application based on the Chinese invention patent application number 201080013035.9 (international application number PCT / US2010 / 025089), the title of the invention "lacrimal gland implant and related methods", and the filing date is February 23, 2010 Apply. [0002] Cross-references to related applications [0003] This patent application claims from U.S. Provisional Patent Application No. 61 / 154,693, filed February 23, 2009, and entitled "Lacrimal Implants and Related Methods"; Lacrimal Implants and Related Methods," U.S. Provisional Patent Application No. 61 / 209,036; U.S. Provisional Patent Application No. 61 / 209,630, filed March 9, 2009, entitled "Lacrimal Implants and Related Methods" ; U.S. Provisional Patent Application No. 61 / 271,862, entitled "Lacrimal Implants and Related Methods," filed July 27, 2009; and "Lacrimal Implants," filed October 15, 2009 61 / 252,057, all of which are pending and incorporated herein by refe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/00A61F9/007A61K9/00A61F2/04
CPCA61F9/0008A61F9/00772A61K9/0051A61F2250/0003A61F2/14A61F9/00A61L27/54A61L27/52
Inventor A·R·拉帕基V·鲁宾奇克C·R·谢尔波特恩
Owner MATI THERAPEUTICS
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