Pharmaceutical composition and its application

A composition and drug technology, applied in the field of pharmaceutical compositions, can solve the problem of not showing the positive effect of antioxidants, and achieve the effects of reducing infarction, edema, and reducing damage

Active Publication Date: 2020-01-17
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, little is known about the role of NAC administered after ischemia in the treatment of focal cerebral ischemia
[0004] It has been disappointing that neuroprotective drugs did not show positive effects of antioxidants in clinical trials

Method used

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  • Pharmaceutical composition and its application
  • Pharmaceutical composition and its application
  • Pharmaceutical composition and its application

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Experimental program
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Embodiment 1

[0031] 1. Nervous and vascular protective effects of combined treatment of normal pressure high concentration oxygen (NBO) and N-acetylcysteine ​​(NAC) on the acute phase after ischemia-reperfusion: brain of male Sprague-Dawley rats (270-290g) The middle artery was exposed to NBO (95% O 2 ) or normoxia (21% O 2 ) during 2 h of occlusion, followed by 48 h of reperfusion. Rats were intraperitoneally injected with NAC (60 mg / kg) or corresponding solvent 5 minutes before reperfusion. The experiment was divided into four groups: (1) Air+Veh group; (2) Air+NAC group; (3) NBO+NAC group; (4) NBO+Veh group. 48 hours after reperfusion, cerebral infarct volume, BBB damage, behavioral score, free radical production, HIF-1α, PARP, and VEGF were detected.

[0032] Neuroprotective effect of NBO combined with NAC in the chronic phase after ischemia-reperfusion: Male Sprague-Dawley rats (270-290 g) were exposed to NBO (95% O 2 ) or normoxia (21%O 2 ), followed by 7 days of reperfusion. Rat...

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Abstract

The invention relates to the technical field of biology, in particular to a medicine composition and application thereof. The medicine composition is composed of normal-pressure high-concentration oxygen (NBO) and N-acetylcysteine (NAC). Due to combined action of NBO supplied in the acute cerebral ischemia stage and NAC supplied during reperfusion, infarct and edema caused after reperfusion can be remarkably reduced, and the effect is obviously better than that of single treatment. Due to the combined action of NBO and NAC, ischemia can be obviously shortened by 2 h, and animal brain atrophy, brain tissue injuries and nerve function impairment which are caused 7 days after reperfusion can be reduced. The effect of combined treatment is obviously better than that of single treatment. Due to the combined action of NBO and NAC, generation of low-oxygen radials, PARP-1 pyrolysis and PAR accumulation can be remarkably reduced. The effect of combined treatment is remarkably better than that of single treatment. Due to the combined action of NBO and NAC, damage of ischemia reperfusion to blood-brain barrier (BBB) and degradation of zonula occluden can be remarkably reduced.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a pharmaceutical composition and its application. Background technique [0002] The primary goal of acute ischemic stroke is to salvage the penumbra, which will develop irreversible damage if it cannot be reperfused. This injury is first due to hypoxia and bioenergetic depletion during ischemia, followed by reperfusion-induced injury [3] . This concept of the penumbra inspires the direction of our drug development to block the cell death pathway. [0003] Neuroprotection alone may not be sufficient to treat acute stroke if tissue is not reperfused or if vascular integrity is compromised. However, reperfusion is accompanied by additional damage due to several mechanisms, such as inflammation, oxidative stress, and excitatory injury. N-acetylcysteine ​​(NAC), a precursor of glutathione, is used clinically as an antioxidant and as an oxygen free radical scavenger. NAC preconditioni...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61P9/10A61P25/00A61P9/14A61P7/10A61P39/06A61K31/198
CPCA61K31/198A61K33/00A61K2300/00
Inventor 金新春刘春风刘文兰刘玉珊孙艳芸
Owner SUZHOU UNIV
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