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Purification process of high-purity isoalantolactone

A high-purity technology of isoinulin, applied in directions such as organic chemistry, can solve the problems of complex purification of isoinulin, high benzene toxicity, unfavorable industrial production, and high cost, shortening the production cycle, facilitating industrial production, The effect of less environmental pollution

Inactive Publication Date: 2016-10-12
成都格利普生物科技有限公司
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Problems solved by technology

This method needs to be separated and purified by preparative liquid phase, and the toxicity of acetonitrile and benzene is not conducive to industrial production, and the cost is high. As mentioned above, the existing process is more complicated for the purification of xenocyanolactone, and the pollution is relatively large

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  • Purification process of high-purity isoalantolactone

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Embodiment Construction

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0021] see figure 1 , is a process flow diagram of an embodiment of the purification process using the high-purity isoinulin provided by the present invention.

[0022] The purification process 1 of the high-purity isoinulin includes the following steps:

[0023] Step S11, crushing the medicinal materials: take the medicinal materials of Zangmuxiang and crush 60-100 meshes;

[0024] Step S12, rough separation with silica gel column: extract the ...

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Abstract

The invention provides a purification process of high-purity isoalantolactone. The purification process comprises the following steps: step I, herb crushing: taking and crushing radix inulae racemosae to be 60-100 meshes; step II, silica-gel column crude separation: mixing the crushed herb and 95% ethyl alcohol at the material-to-liquor ratio of 1:8, extracting a filtrate under a 60 DEG C water bath condition, performing silica-gel column chromatography, conducting gradient washing by use of a petroleum ether-ethyl acetate system, and collecting a product; step III, recrystallization: the collected product is concentrated to be less in quantity, and the concentrated product is placed in a refrigerator for crystallization. The purification process of high-purity isoalantolactone adopts the silica-gel column and recrystallization measures to separate and purify isoalantolactone, has the advantages of short production period, low solvent consumption, less environmental pollution and the like, and is more conductive to industrial production.

Description

technical field [0001] The invention belongs to the field of isoinulin technology, in particular to a purification process of high-purity isoinulin. Background technique [0002] Isoinulin is present in the root of the Compositae plant, Ihula helenium L.. Chinese alias: isoalan lactone. Molecular formula: C15H20O2, molecular weight: 232.3181. Physical and Chemical Properties: Density: 1.07g / cm3 Melting Point: 112-115℃ Boiling Point: 364.9℃at 760mmHg. Properties: Prismatic crystal. Solubility: Soluble in ethanol, ether, benzene and chloroform, slightly soluble in petroleum English, insoluble in water. Isoinulin has anthelmintic and antiprotozoal effects. It has obvious inhibitory effect on Trichophyton mentagrophytes and Microsporidia. Has a strong anti-tuberculosis and other microorganisms. Zangmuxiang belongs to the Compositae family, and uses the roots of plants as medicines. Efficacy and indications, invigorating the spleen and stomach, regulating qi and relieving ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/92
CPCC07D307/92
Inventor 林鹏冉波刘伊敏阎志鹏
Owner 成都格利普生物科技有限公司
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