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Compound Ilex pubescens oral liquid and preparation method and application thereof

A technology of compound Maodongqing and oral liquid, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc.

Active Publication Date: 2016-10-26
JUMPCAN PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for infants, young children, elderly patients and patients with chronic diseases, it is easy to have complications and cause serious consequences.

Method used

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  • Compound Ilex pubescens oral liquid and preparation method and application thereof
  • Compound Ilex pubescens oral liquid and preparation method and application thereof
  • Compound Ilex pubescens oral liquid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Take 100g of Houttuynia cordata and add 6 times the amount of water for distillation, collect 300mL of distillate, and set aside; heat and extract 600g of hollywort, 100g of Polygonum chinensis leaves and 100g of Radix isatidis plus 8 times of the amount of water once, 1 hour each time , filter, combine the water decoction, concentrate under reduced pressure to a clear paste with a relative density of 1.06 (50°C), add ethanol to make the alcohol content reach 50%, stir well to make it uniform, leave it overnight, filter, take the ethanol solution, Recover ethanol under reduced pressure to a clear paste with no alcohol smell; add Houttuynia cordata distillate and water to the above clear paste to make up to 750mL, add 2g of sodium benzoate, adjust the pH value to 6.8 with 20% sodium hydroxide solution, and mix well , refrigerate for 24 hours, filter, add 200mL of simple syrup to the filtrate, add water to 1000mL, stir well, filter, fill, sterilize, and get ready.

Embodiment 2

[0068] Take 200g Houttuynia cordata and add 10 times the amount of water to distill, collect 300mL of distillate, and set aside; heat and extract 800g of Ilex pubescens, 200g of Polygonum chinensis leaves and 200g of Radix isatidis plus 12 times of the amount of water for 3 times, each time for 2h , filter, combine the water decoction, concentrate under reduced pressure to a clear paste with a relative density of 1.10 (50°C), add ethanol to make the alcohol content reach 70%, stir well to make it uniform, leave it overnight, filter, take the ethanol solution, Recover ethanol under reduced pressure to an alcohol-free clear paste; add Houttuynia cordata distillate and water to the above clear paste to make up to 750mL, add 2g of sodium benzoate, adjust the pH value to 7.2 with 20% sodium hydroxide solution, and mix well , refrigerate for 48 hours, filter, add 200mL of simple syrup to the filtrate, add water to 1000mL, stir well, filter, fill, sterilize, and get ready.

Embodiment 3

[0070] Take 300g of Houttuynia cordata and add 6 times the amount of water for distillation, collect 300mL of distillate, and set aside; heat and extract 1000g of Ilex pubescens, 300g of Polygonum chinensis leaves and 300g of Radix isatidis plus 12 times of the amount of water twice, each time for 1h , filter, combine the water decoction, concentrate under reduced pressure to a clear paste with a relative density of 1.10 (50°C), add ethanol to make the alcohol content reach 60%, stir well to make it uniform, leave it overnight, filter, take the ethanol solution, Recover ethanol under reduced pressure to a clear paste with no alcohol smell; add Houttuynia cordata distillate and water to the above clear paste to make up to 750mL, add 2g of sodium benzoate, adjust the pH value to 7.0 with 20% sodium hydroxide solution, and mix well , refrigerate for 72 hours, filter, add 200mL of simple syrup to the filtrate, add water to 1000mL, stir well, filter, fill, sterilize, and get ready. ...

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Abstract

The invention relates to a traditional Chinese medicine compound preparation and a preparation method and application thereof, in particular to compound Ilex pubescens oral liquid and a preparation method thereof and application of the Ilex pubescens oral liquid to the preparation of medicine for treating upper respiratory infection symptoms such as fever, cough and sore throat. The compound Ilex pubescens oral liquid comprises, by weight, 3-5 parts of Ilex pubescens, 0.5-1.5 parts of Polygonum tinctorium Ait., 0.5-1.5 parts of radix isatidis and 0.5-1.5 parts of cordate houttuynia. The preparation method includes: evenly mixing cordate houttuynia water distillate with aqueous extract clear paste of Ilex pubescens, Polygonum tinctorium Ait. and radix isatidis, regulating pH, filtering, filling and sterilizing to obtain the compound Ilex pubescens oral liquid. By the preparation method which is simple to operate, capable of lowering cost and especially suitable for industrial production, final product quality can be improved evidently.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation and its preparation method and application, in particular to a compound Maodongqing oral liquid and its preparation method and application. Background technique [0002] Ilex pubescens is a plant of the genus Ilex (Ilex pubescens Hook.et Arn.) of the Ilex family (Ilex pubescens Hook.et Arn.), also known as Wuwei Ding, Mao Phishu, etc. It has the functions of clearing away heat and detoxifying, promoting blood circulation and dredging the veins. It is widely used clinically to treat wind-heat and cold. Breathing and coughing due to lung heat, laryngeal edema, tonsillitis, dysentery, coronary heart disease, acute myocardial infarction, thromboangiitis obliterans, external use to treat burns, scalds, chilblains, etc. Modern pharmacological studies have shown that most of the heat-clearing and detoxifying traditional Chinese medicines have antiviral effects. [0003] Cold is a di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/08A61P11/00A61P29/00A61P11/14A61P11/04
CPCA61K9/08A61K36/185A61K36/195A61K36/315A61K36/704A61K36/78A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 曹龙祥董自波田刚李超邵建国李萍
Owner JUMPCAN PHARMA GRP
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