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Microfluidic chip with conic bead trapping cavities and fabrication thereof

A microfluidic chip and trapping technology, applied in fluid controllers, semiconductor/solid-state device manufacturing, laboratory equipment, etc.

Inactive Publication Date: 2016-11-09
IBM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such solutions lead to a trade-off between signal strength and signal quality
Bead stability is increasingly problematic

Method used

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  • Microfluidic chip with conic bead trapping cavities and fabrication thereof
  • Microfluidic chip with conic bead trapping cavities and fabrication thereof
  • Microfluidic chip with conic bead trapping cavities and fabrication thereof

Examples

Experimental program
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Embodiment Construction

[0042] First, and generally refer to Figure 1-4 and 11-13, describe aspects of the invention related to the microfluidic chip 100. The chip obviously comprises a working layer 10, 60 comprising an array 30 of bead trapping cavities 20 (also called traps) disposed therein. Notably, each of the cavities 20 has a tapered shape surrounded by one or more side walls 21-24. Importantly, the side wall(s) are hydrophilic and each of the cavities 20 extends as a blind hole in the thickness of the working layer 10 , 60 .

[0043] The working layer 10 , 60 may be the substrate layer 10 or the capping layer 60 . The cavity is preferably provided in the thickness of the layer whose surface is the bottom or top wall of the microfluidic channel or channel portion 12a, such as figure 2 shown in .

[0044]In this application, "conical" also means "conical", ie having a cone-like form. By "cone", and consistent with a general definition of a cone (http: / / en.wikipedia.org / wiki / Cone), it me...

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PUM

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Abstract

A microfluidic chip (100) comprises a layer (10, 60) with an array (30) of bead trapping cavities (20) provided in that layer (10, 60), wherein each of the cavities (20) has a conic shape, defined by one or more lateral walls (21-24) that are, each, hydrophilic, and wherein each of the cavities (20) extends as a blind hole in the thickness of said layer (10, 60). Methods of fabrication of such a chip are further provided.

Description

technical field [0001] The present invention relates generally to the field of microfluidic chips, and in particular to microfluidic chips equipped with bead trapping chambers, eg for bioanalytical applications, and related manufacturing methods. Background technique [0002] Microfluidic devices generally refer to microfabricated devices for pumping, sampling, mixing, analyzing and dosing liquids. The outstanding features of microfluidic devices arise from the special behavior of liquids on the micrometer length scale. The flow of liquids in microfluidic devices can typically be laminar. Volumes well below one nanoliter can be obtained by fabricating structures with lateral dimensions in the micrometer range. Reactions that are confined on a large scale (by the diffusion of reactants) can thus be accelerated. Microfluidic devices are thus used in a variety of applications. [0003] Many microfluidic devices have user chip interfaces and closed flow paths. The closed fl...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N33/554G01N33/543H01L21/00
CPCB01L3/502707B01L3/502761B01L2200/0668B01L2300/0864B01L2300/0867B01L2300/0887B01L2400/086B01L3/00B01L3/5027B01L3/502715G01N33/53G01N33/543G01N33/554H01L21/00
Inventor E·德拉马尔什Y·特米兹
Owner IBM CORP