A kind of preparation method of phenylpropanoid flavoring agent and its combined application with cigarette moisturizing agent

A technology of phenylpropanoid and solvent, which is applied in the field of tobacco chemistry, can solve problems that have not been seen, and achieve the effects of simple structure, novel structure, and improved roundness and comfort

Active Publication Date: 2018-05-18
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, phenylpropanoid compounds are also important components of natural flavors. Natural and synthetic phenylpropanoid compounds are widely used in the food and flavor industries. Functional phenylpropanoid compound, which has not been reported so far

Method used

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  • A kind of preparation method of phenylpropanoid flavoring agent and its combined application with cigarette moisturizing agent
  • A kind of preparation method of phenylpropanoid flavoring agent and its combined application with cigarette moisturizing agent
  • A kind of preparation method of phenylpropanoid flavoring agent and its combined application with cigarette moisturizing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A phenylpropanoid compound C 14 h 18 o 5 The preparation method specifically comprises the following steps:

[0034] (1) Preparation of tobacco extract extract: use air-dried tobacco leaves as raw material, crush or cut the tobacco leaves into small pieces, soak and extract the tobacco leaves 4 times with the first solvent, 54 hours each time, combine the extracts, filter and concentrate Obtain the tobacco extract extract; wherein the first solvent is a mixture of an organic solvent selected from methanol, ethanol or acetone and water, when the first solvent is a mixture of methanol or ethanol and water, wherein methanol or Ethanol accounts for 95wt% of the first solvent, and when the first solvent is a mixture of acetone and water, wherein acetone accounts for 70wt% of the first solvent; and the first solvent:tobacco=3:5, weight ratio;

[0035] (2) Silica gel column chromatography: after dissolving the second solvent selected from pure methanol, pure ethanol or pure...

Embodiment 2

[0039] The air-cured tobacco samples used come from Tengchong, Yunnan, and the variety is Tengchong Tengruan Raw Tobacco. Sampling 2.0 kg of tobacco leaves and pulverizing them, extracting 5 times with 95% methanol for 24 hours each time, combining the extracts, filtering, and concentrating under reduced pressure to obtain 95 g of tobacco extract extract. After dissolving the above-mentioned tobacco extract extract with pure methanol of 2.0 weight multiples, mix the sample with 100 mesh thick silica gel of 120g, then mix with 0.6kg of 160 mesh silica gel and carry out silica gel column chromatography with a volume ratio of 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring Merge the same fractions to get 8 fractions , wherein the chloroform-acetone eluted part with a volume ratio of 7:3 was separated by Agilent 1100 semi-preparative high performance liquid chromatography, with 46% methanol as mobile phase, prepared by Zorbax SB-C18 (21....

Embodiment 3

[0042] The air-cured tobacco samples used were from Dali, Yunnan, and the variety was Yunlong Tiandeng tobacco. Sampling 3.5 kg of tobacco leaves and chopping them up, extracting 4 times with 95% ethanol for 48 hours each time, combining the extracts, filtering, and concentrating under reduced pressure to obtain 245 g of tobacco extract extract. The above-mentioned tobacco extract extract is dissolved with its 2.0 weight times of pure methanol and mixed with 250g of 80 mesh thick silica gel, then mixed with 1.2kg of 200 mesh silica gel and then packed into a column for silica gel column chromatography, with a volume ratio of 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring Merge the same fractions to get 8 fractions , wherein the chloroform-acetone eluted part with a volume ratio of 7:3 was separated by Agilent 1100 semi-preparative high performance liquid chromatography, with 46% methanol as mobile phase, prepared by Zorbax SB-C18 (2...

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Abstract

The invention discloses a phenylpropanoid compound. The compound is named as 3-(3,4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate. A molecular formula IS C14H18O5 and has the following structure (shown in the description). The invention further discloses a preparation method of the compound and application for improving the cigarette smoking quality thereof.

Description

technical field [0001] The invention belongs to the technical field of tobacco chemistry, in particular to a phenylpropanoid compound extracted from air-cured tobacco for the first time. At the same time, the present invention also relates to the preparation method of the compound and its combined application with a humectant to improve the smoking quality of cigarettes. Background technique [0002] Tobacco is the plant with the most complex chemical composition in the world, and its secondary metabolites are very rich. After decades of research, more than 3,000 monomeric chemical substances have been identified from tobacco, and many components have not yet been identified. come out. Although smoking is widely recognized as harmful to health, tobacco still has a strong appeal to thousands of consumers. In addition to the addictive properties of nicotine, the rich flavor substances in tobacco also play an important role. [0003] Phenylpropanol is a naturally occurring co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/18C07C67/48A24B15/24
CPCA24B15/241C07C67/48C07C69/18
Inventor 刘春波张天栋刘志华申钦鹏周博赵英良张凤梅何沛杨光宇缪明明陈永宽
Owner CHINA TOBACCO YUNNAN IND
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