Compound traditional Chinese medicine nanometer emulsifiable paste for treating skin chap

A compound traditional Chinese medicine and skin chapped technology, which is applied in the field of medicine to achieve the effects of safe excipients, promoting the healing of damaged skin, and being easy to carry and use.

Inactive Publication Date: 2016-11-23
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previous studies have found that Chinese herbal medicines have shown certain curative effects in treating chapped skin, and have the advantages of being safe and easy to use. However, there have been no public reports of effective Chinese medicines. Therefore, a compound prescription for chapped hands and feet has been developed using Chinese medicines as raw materials. It is imperative to make the compound into a nanoemulsion with good dispersion system and drug release system

Method used

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  • Compound traditional Chinese medicine nanometer emulsifiable paste for treating skin chap
  • Compound traditional Chinese medicine nanometer emulsifiable paste for treating skin chap

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: The compound traditional Chinese medicine nano-cream for treating chapped skin, including Chinese medicine extract and nano-emulsion matrix, the mass ratio of Chinese medicine extract and nano-emulsion matrix is ​​10:100;

[0013] The traditional Chinese medicine extract is a compound of Bletilla striata polysaccharide and shikonin in an equal mass ratio;

[0014] The nanoemulsion matrix includes 10% isopropyl palmitate and 90% mixed surfactant in terms of mass percentage; the isopropyl palmitate is heated and melted in a constant temperature water bath at 80°C, and the surfactant and co-surfactant are added In isopropyl palmitate, stir, dissolve, place, and cool to obtain the nanoemulsion matrix, add the Chinese medicine extract to the nanoemulsion matrix and stir evenly to obtain the product;

[0015] The mixed surfactant is a composition of a surfactant and a co-surfactant at a mass ratio of 4:1;

[0016] The surfactant is composed of Tween 80 and polyoxy...

Embodiment 2

[0018] Example 2: The compound traditional Chinese medicine nano-cream for treating chapped skin, including Chinese medicine extract and nano-emulsion matrix, the mass ratio of Chinese medicine extract and nano-emulsion matrix is ​​20:100;

[0019] The traditional Chinese medicine extract is a compound of Bletilla striata polysaccharide and shikonin in an equal mass ratio;

[0020] The nanoemulsion matrix includes 20% isopropyl palmitate and 80% mixed surfactant in terms of mass percentage; the isopropyl palmitate is heated and melted in a constant temperature water bath at 80°C, and the surfactant and co-surfactant are added In isopropyl palmitate, stir, dissolve, place, and cool to obtain the nanoemulsion matrix, add the Chinese medicine extract to the nanoemulsion matrix, and stir evenly to obtain the product;

[0021] The mixed surfactant is a composition of a surfactant and a co-surfactant at a mass ratio of 4:1;

[0022] The surfactant is composed of Tween 80 and polyox...

Embodiment 3

[0024] Example 3: The compound traditional Chinese medicine nano-cream for treating chapped skin, including Chinese medicine extract and nano-emulsion matrix, the mass ratio of Chinese medicine extract and nano-emulsion matrix is ​​30:100;

[0025] The traditional Chinese medicine extract is a compound of Bletilla striata polysaccharide and shikonin in an equal mass ratio;

[0026] The nanoemulsion matrix includes 30% isopropyl palmitate and 70% mixed surfactant in terms of mass percentage; the isopropyl palmitate is heated and melted in a constant temperature water bath at 80°C, and the surfactant and co-surfactant are added In isopropyl palmitate, stir, dissolve, place, and cool to obtain the nanoemulsion matrix, add the Chinese medicine extract to the nanoemulsion matrix, and stir evenly to obtain the product;

[0027] The mixed surfactant is a composition of a surfactant and a co-surfactant at a mass ratio of 4:1;

[0028] The surfactant is composed of Tween 80 and polyox...

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Abstract

The invention aims at providing compound traditional Chinese medicine nanometer emulsifiable paste for treating skin chap. The compound traditional Chinese medicine nanometer emulsifiable paste contains a nanometer emulsion substrate and a traditional Chinese medicine extract, wherein the nanometer emulsion substrate contains an isopropyl palmitate substance and a mixed surfactant; isopropyl palmitate and the traditional Chinese medicine extract are put into 80-DEG C constant temperature water bath for heating melting; a surfactant and a cosurfactant are put into the isopropyl palmitate; stirring, dissolving, placing and cooling are performed; the mixed surfactant is a composition of the surfactant and the cosurfactant; the surfactant is prepared from Tween-80 and polyoxyethylene hydrogenated castor oil; the cosurfactant is one of glycerol, absolute ethyl alcohol or polyethylene glycol 400; the traditional Chinese medicine extract is a compound of rhizoma bletillae polysaccharide and alkannin. The nanometer emulsifiable paste has the advantages that the formula is reasonable; the storage stability is good; in the use process, the oily feeling is avoided; the emulsion droplet grain diameter is small; the emulsifiable paste can be fast absorbed in the medicine use position. The recipe process of the compound traditional Chinese medicine nanometer emulsifiable paste is reasonable; green and environment-friendly effects are achieved in the manufacturing process; the carrying and the use are convenient; the auxiliary materials are safe; the price is moderate.

Description

technical field [0001] The invention relates to medicine, in particular to a compound traditional Chinese medicine nano-emulsion for treating chapped skin. Background technique [0002] Chapped skin is a common disease in dermatology, and it mostly occurs in the cold and dry seasons of winter and spring. Its clinical manifestations are: thickened, dry, rough, chapped skin on the palms and soles of the feet, even accompanied by bleeding and pain. The disease tends to recur periodically every winter and spring. In mild cases, only the superficial skin is involved, affecting the appearance of the skin. In severe cases, it can penetrate deep into the dermis and subcutaneous tissue, causing bleeding, pain, limited flexion and extension of the hands, severe chapped feet, and severe walking pain, which affects patients. Daily work and life, bring pain to patients. The traditional treatment of modern medicine for this disease is to use urea ointment or salicylic acid ointment for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K9/107A61K47/44A61P17/02
CPCA61K9/1075A61K31/122A61K31/715A61K36/898A61K47/44A61K2300/00
Inventor 魏玉许海涛王彬郭燕
Owner HENAN UNIV OF CHINESE MEDICINE
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