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Radiation crosslinked silk fibroin hydrogel medical cold compress paste

A silk fibroin and hydrogel technology, applied in medical science, bandages, etc., can solve problems such as inability to be directly applied, long gelation time of pure silk fibroin, and uncontrollable gelation time. Allergy and other toxic side effects, beneficial effects on healing, good biocompatibility

Inactive Publication Date: 2016-12-07
江苏达胜伦比亚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At the same time, pure silk fibroin is used to prepare gels. Pure silk fibroin takes a long time to gel, and the gel time is not easy to control through physical methods such as ultrasound and vortex; and chemical cross-linking agents such as poloxamer and epoxy compounds The addition of etc. has a certain impact on cell biocompatibility and cannot be directly applied to the biomedical field.

Method used

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  • Radiation crosslinked silk fibroin hydrogel medical cold compress paste
  • Radiation crosslinked silk fibroin hydrogel medical cold compress paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) First, weigh 18% starch, 7% polyvinylpyrrolidone, 6% sodium carboxymethylcellulose, 9% silk fibroin solution, and 60% medical purified water for later use.

[0026] (2) Mix the components in step (1) into medical purified water that has been tested in advance and meets the standards. The amount of purified water in this embodiment is not strictly controlled, as long as the above components are completely mixed Just dissolve it, keep stirring at a temperature of 90°C to become a semi-gel state.

[0027] (3) preparing the semi-gel state miscible in step (2) into an initial state hydrogel.

[0028] (4) The hydrogel in the initial state is irradiated with 25-35 kGy of electron beams to prepare the irradiated cross-linked silk fibroin hydrogel medical cold compress.

Embodiment 2

[0030] (1) First, weigh 20% of starch, 7% of polyvinylpyrrolidone, 5% of sodium carboxymethylcellulose, 11% of silk fibroin solution, and 57% of medical purified water for later use.

[0031] (2) Mix the components in step (1) into medical purified water that has been tested in advance and meets the standards. The amount of purified water in this embodiment is not strictly controlled, as long as the above components are completely mixed It can be dissolved, and it will become a semi-gel state at a temperature of 90°C.

[0032] (3) preparing the semi-gel state miscible in step (2) into an initial state hydrogel.

[0033] (4) The hydrogel in the initial state is irradiated with 25-35 kGy of electron beams to prepare the irradiated cross-linked silk fibroin hydrogel medical cold compress.

Embodiment 3

[0035] (1) First, weigh 15% starch, 12% polyvinylpyrrolidone, 9% sodium carboxymethylcellulose, 7% silk fibroin solution, and 57% medical purified water, and set aside.

[0036] (2) Mix the components in step (1) into medical purified water that has been tested in advance and meets the standards. The amount of purified water in this embodiment is not strictly controlled, as long as the above components are completely mixed It can be dissolved, and it will become a semi-gel state at a temperature of 90°C.

[0037] (3) preparing the semi-gel state miscible in step (2) into an initial state hydrogel.

[0038] (4) The hydrogel in the initial state is irradiated with 25-35 kGy of electron beams to prepare the irradiated cross-linked silk fibroin hydrogel medical cold compress.

[0039] The silk fibroin solution of the present invention is dissolved and boiled in 0.03mol / L sodium carbonate for 30min by putting silkworm raw silk into 0.03mol / L sodium carbonate and rinsing with deion...

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Abstract

The invention belongs to the technical field of medical appliances, and relates to a radiation crosslinked silk fibroin hydrogel medical cold compress paste comprising the following components in a formula: 15-20 wt% of starch, 7-12 wt% of polyvinyl pyrrolidone, 5-9 wt% of sodium carboxymethyl cellulose, 7-11 wt% of a silk fibroin solution, and a solvent enough to fully dissolve the other components. The silk fibroin solution added to the radiation crosslinked silk fibroin hydrogel medical cold compress paste has good biocompatibility on human skin, can prevent allergies and other toxic and side effects, and is conducive to healing of wounds.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to an irradiation cross-linked silk fibroin hydrogel medical cold compress with good biocompatibility. Background technique [0002] Irradiation cross-linked silk fibroin hydrogel medical cold compress is mainly a gel-like material composed of some polymer copolymers, cross-linking agents, deionized water and other substances. There are many types and can be used in medicine and surgery . For example, hydrogel dressings replace traditional gauze as wound dressings, because the gel state of hydrogel itself is softer than traditional gauze, and it can also absorb wound secretions and reduce the chance of wound infection; and silk fibroin not only It has affinity to human skin, and can accelerate tissue repair and wound healing. At present, general medical hydrogel products are mainly used to treat wounds. As a material in contact with lenses and artificial cartilage, silk f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/28C08J3/24C08L3/02C08L89/00C08L39/06C08L1/28
CPCA61L26/0014A61L26/0023A61L26/0028A61L26/008C08J3/246C08J3/28C08J2303/02C08J2401/28C08J2439/06C08J2489/00C08L3/02C08L1/286C08L39/06
Inventor 肖峰林家财武传业于亚益
Owner 江苏达胜伦比亚生物科技有限公司
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