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A kind of iron glucoheptose nanoemulsion and preparation method thereof

A technology of iron glucoheptanoside and nanoemulsion, which is applied in the directions of pharmaceutical formulations, emulsion delivery, medical preparations of inactive ingredients, etc., can solve piglet stress and other complications, iron injection pain, strong irritation and other problems to achieve the effect of improving bioavailability, reducing irritation, and facilitating operation

Active Publication Date: 2020-05-01
TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of iron supplements on the market, but most iron injections are painful and irritating, which can easily cause stress and other complications in piglets

Method used

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  • A kind of iron glucoheptose nanoemulsion and preparation method thereof
  • A kind of iron glucoheptose nanoemulsion and preparation method thereof
  • A kind of iron glucoheptose nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of iron glucoheptose anhydrous nanoemulsion, which is prepared by the group comprising the following parts by weight: 10 parts of iron glucoheptose anhydride, 13.4 parts of Tween80, 6.6 parts of Span80, 15 parts of glycerin, 15 parts of soybean oil, 10 parts of water for injection share.

[0032] The preparation method of the above-mentioned iron glucoheptose anhydrous nanoemulsion injection comprises the following steps:

[0033] (1) respectively take by weighing the iron glucoheptose anhydrous, surfactant, cosurfactant, oil content, water for injection of recipe quantity, for subsequent use;

[0034] (2) adding the iron glucoheptose anhydrous of recipe quantity in water for injection, stirring, as water for subsequent use;

[0035] (3) in a 40 ℃ water bath, add the surfactant and the cosurfactant in the recipe amount to the oil and mix them evenly, as the oil phase for subsequent use;

[0036] (4) in a 40° C. water bath, the water phase containing iron glucoh...

Embodiment 2

[0038] A kind of iron glucoheptose anhydrous nanoemulsion, prepared by the group comprising the following parts by weight: 30 parts of iron glucoheptose anhydride, 40 parts of Tween80, 20 parts of Span80, 15 parts of glycerin, 45 parts of soybean oil, 30 parts of water for injection share.

[0039] The preparation method of the above-mentioned iron glucoheptose anhydrous nanoemulsion injection comprises the following steps:

[0040] (1) respectively take by weighing the iron glucoheptose anhydrous, surfactant, cosurfactant, oil content, water for injection of recipe quantity, for subsequent use;

[0041] (2) adding the iron glucoheptose anhydrous of recipe quantity in water for injection, stirring, as water for subsequent use;

[0042] (3) in a 40 ℃ water bath, add the surfactant and the cosurfactant in the recipe amount to the oil and mix them evenly, as the oil phase for subsequent use;

[0043] (4) in a 40° C. water bath, the water phase containing iron glucohepton anhydr...

Embodiment 3

[0045] A kind of iron glucoheptose anhydrous nanoemulsion, prepared by the group comprising the following parts by weight: 15 parts of iron glucoheptose anhydride, 20 parts of Tween80, 10 parts of Span80, 7.5 parts of glycerin, 22.5 parts of soybean oil, 15 parts of water for injection share.

[0046] The preparation method of the above-mentioned iron glucoheptose anhydrous nanoemulsion injection comprises the following steps:

[0047] (1) respectively take by weighing the iron glucoheptose anhydrous, surfactant, cosurfactant, oil content, water for injection of recipe quantity, for subsequent use;

[0048] (2) adding the iron glucoheptose anhydrous of recipe quantity in water for injection, stirring, as water for subsequent use;

[0049] (3) in a 40 ℃ water bath, add the surfactant and the cosurfactant in the recipe amount to the oil and mix them evenly, as the oil phase for subsequent use;

[0050] (4) in a 40° C. water bath, the water phase containing iron glucohepton anh...

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Abstract

The present invention provides a gleptoferron nano-emulsion and a preparation method thereof, wherein the gleptoferron nano-emulsion is prepared from the following components by weight: 10-30 parts of gleptoferron, 20-60 parts of a surfactant, 5-15 parts of an auxiliary surfactant, 15-45 parts of an oil component, and 10-30 parts of water for injection. The gleptoferron nano-emulsion of the present invention has good thermodynamic stability, can completely restore the stable emulsion state after heating to a temperature of 80 DEG C, standing and complete vibration, has good storage stability, and cannot be layered after standing.

Description

technical field [0001] The invention belongs to the field of iron glucoheptose anhydrous pharmaceutical preparations and a preparation method thereof, and in particular relates to an iron glucoheptose anhydrous nanoemulsion and a preparation method thereof. Background technique [0002] Because the iron contained in piglets at birth is far from their growth requirements, in modern intensive farms, piglets are artificially injected with iron after birth to ensure the best growth performance of piglets. There are many types of iron supplements on the market, but most iron injections are painful and irritating, which can easily cause piglet stress and other complications. Iron glucoheptonide is a high-molecular iron supplement successfully developed in recent years. This iron can be quickly absorbed by the body from the injection site and can be safely used in 1-day-old piglets. Therefore, it is very necessary to invent a kind of iron glucoheptose nanoemulsion with low injecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/26A61K47/10A61K47/44A61K31/721A61P7/06
CPCA61K9/1075A61K33/26A61K47/10A61K47/26A61K47/44
Inventor 于小婷范庆增王建程雪娇焦晓军余贵菊王勇朱士江王猛季昆姜淋洁崔志刚张立会甄盼盼杨雪王宇鹏李丽琴杜宁宁李玲
Owner TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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