Composite artificial blood vessel

A kind of artificial blood vessel, composite technology, applied in coating, medical science, prosthesis and other directions, can solve the problems of easy cracking of coating, blood leakage, etc., and achieve the effect of solving the problems of permeability resistance and biocompatibility

Inactive Publication Date: 2016-12-21
JIANGSU BIODA LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the artificial blood vessel prepared by this method, the coating only exists on the surface of the artificial vascular prosthesis, and the pores are not filled. During the operation, when the doctor folds and sutures, the coating is easily broken, resulting in blood leakage

Method used

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  • Composite artificial blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Freshly frozen bovine tendon was treated with 3% sodium carbonate for 30 minutes, and then soaked in 0.01M HCl solution for 2 hours. Treated bovine tendon with 1M NaSO 4 Treat for 30min, then soak in 0.5M NaOH for 10h. After washing 3 times with water, wash 3 times with 0.01M HCl solution. Freeze-dried for later use.

[0026] The polyester Y-shaped artificial blood vessel was prepared by weaving. The bovine collagen extracted above was formulated into a solution with a concentration of 0.5 mg / mL. The collagen solution was injected into the artificial blood vessel by vacuum-assisted-resin transfer molding for 20 minutes. The artificial blood vessel was taken out, placed in a 30°C oven for drying, and the above operation was repeated 4 times.

[0027] The water permeability of the uncoated artificial blood vessel is 80ml / min·cm2. The water permeability test of the coated artificial blood vessel was found to be 1ml / min·cm2, which significantly reduced the water perme...

Embodiment 2

[0029] The polyester straight-tube artificial blood vessel was prepared by weaving. Prepare a gelatin solution with a concentration of 1 mg / mL and a plasticizer of polyethylene glycol with a concentration of 0.03 mg / ml. In a closed container, vacuumize the artificial blood vessel, thereby injecting the gelatin solution into the artificial blood vessel for 10 min. The artificial blood vessel was taken out, placed in a 30°C oven for drying, and the above operation was repeated 6 times.

[0030] The water permeability test of the prepared composite artificial blood vessel shows that the water permeability is 2ml / min·cm2, which obviously reduces the water permeability.

Embodiment 3

[0032] The polyester tubular artificial blood vessel is prepared by a knitting method, and after being shaped, three side branches are sutured on the main body. Porcine collagen was prepared according to the method in Example 1, and then a collagen solution was prepared with a concentration of 0.5 mg / mL. The collagen solution was injected into the artificial blood vessel for 10 minutes. The artificial blood vessel was taken out, placed in a 30°C oven for drying, and the coating and drying operation was repeated 5 times. The prepared composite artificial blood vessel was tested for water permeability, and the result was 0.5ml / min·cm2, which obviously reduced the water permeability.

[0033] To sum up, a kind of composite artificial blood vessel provided by the present invention has the following advantages: 1) the pores of the vascular prosthesis are filled with the coating, which avoids the pre-coagulation operation before the operation, increases the softness and stiffness o...

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Abstract

The invention discloses a composite artificial blood vessel, which can be implanted in a human body, and belongs to the field of processing of bio-medical materials. The composite artificial blood vessel comprises a reinforcing body and a basal body, wherein the reinforcing body is of a textile structure which constitutes a skeleton of the artificial blood vessel; and the basal body is made from a bio-compatible material; and according to a combining method, a basal body solution is uniformly spread in the surfaces and pores of the reinforcing body and is dried. The composite artificial blood vessel disclosed by the invention is good in penetration resistance and biocompatibility, so that a pre-operative preliminary coagulation operation is avoided, and the success rate of a surgery and the convenience of surgical operations are improved.

Description

technical field [0001] The invention relates to a medical device surgical implant, in particular to a compound artificial blood vessel. Background technique [0002] At present, it is an important surgical technique to replace human diseased blood vessels with artificial vascular prosthesis. Artificial blood vessels are usually constructed of biocompatible materials such as Dacron, Teflon, polyurethane, and natural mulberry silk. Weaving methods include knitting, weaving and weaving. [0003] The basal layer of the artificial blood vessel is composed of a porous fiber wall. The porous structure can keep the artificial blood vessel sufficiently tight to the blood to avoid excessive blood loss during the operation, and at the same time allow the infiltration and growth of fibroblasts and smooth muscle cells, making the recipient tissue wrap Healing vascular prosthesis. However, this type of artificial blood vessel requires pre-coagulation treatment when it is implanted in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/34A61L27/18A61L27/58
CPCA61L27/18A61L27/34A61L27/50A61L27/507A61L27/58C08L67/02C08L89/06C08L71/02
Inventor 邢蕾
Owner JIANGSU BIODA LIFE SCI CO LTD
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