Preparation and application of pharmaceutical composition of no donor titanium dioxide derivatives

A technology of titanium dioxide and mesoporous titanium dioxide, which is applied in the field of medicine to achieve the effects of good biocompatibility, convenient operation and strong targeting

Active Publication Date: 2019-04-16
ZHONGSHUAI PHARMA SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide the preparation and application of the pharmaceutical composition of NO donor type titanium dioxide derivatives, which can effectively solve the problem of triple-strike interactive comprehensive treatment for tumors, and realize cancer Integration of diagnosis and treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation method of the pharmaceutical composition of NO donor type titanium dioxide derivatives of the present invention comprises the following steps:

[0023] (1) Mix 0.8ml of tetraethyl orthosilicate with 0.45ml of water, 20ml of absolute ethanol and 0.8ml of ammonia water, stir for 12 hours, centrifuge at 14000rpm for 15 minutes to obtain a precipitate, add absolute ethanol to redissolve the precipitate, then centrifuge and redissolve , so repeated twice to obtain hollow mesoporous silica nanoparticles;

[0024] (2) Disperse the hollow mesoporous silica nanoparticles prepared in step (1) in a mixture of 10ml of absolute ethanol and 0.2ml of water, then add 0.3g of hydroxypropyl cellulose and stir for 30min to obtain a solution. Dissolve 2ml of titanium tert-butoxide in 5ml of ethanol, slowly add it dropwise into the above solution with a syringe, reflux at 85°C for 100min, centrifuge at 14000rpm for 8min to obtain a precipitate, add absolute ethanol to rediss...

Embodiment 2

[0030] The preparation method of the pharmaceutical composition of NO donor type titanium dioxide derivatives of the present invention comprises the following steps:

[0031] (1) Mix 0.7ml of tetraethyl orthosilicate with 0.3ml of water, 19ml of absolute ethanol and 0.7ml of ammonia water, stir for 10 hours, centrifuge at 12000rpm for 20 minutes to obtain a precipitate, add absolute ethanol to redissolve the precipitate, then centrifuge and redissolve , so repeated twice to obtain hollow mesoporous silica nanoparticles;

[0032](2) Disperse the hollow mesoporous silica nanoparticles prepared in step (1) in a mixture of 5ml of absolute ethanol and 0.3ml of water, then add 0.1g of hydroxypropyl cellulose and stir for 30min to obtain a solution. Dissolve 1ml of titanium tert-butoxide in 7ml of ethanol, slowly add it dropwise into the above solution with a syringe, reflux at 80°C for 110min, centrifuge at 12000rpm for 10min to obtain a precipitate, add absolute ethanol to redissol...

Embodiment 3

[0038] The preparation method of the pharmaceutical composition of NO donor type titanium dioxide derivatives of the present invention comprises the following steps:

[0039] (1) Mix 0.9ml of tetraethyl orthosilicate with 0.3ml of water, 21ml of absolute ethanol and 0.7ml of ammonia water, stir for 14 hours, centrifuge at 15000rpm for 10min to obtain a precipitate, add absolute ethanol to redissolve the precipitate, then centrifuge and redissolve , so repeated 3 times to obtain hollow mesoporous silica nanoparticles;

[0040] (2) Disperse the hollow mesoporous silica nanoparticles prepared in step (1) in a mixture of 15ml of absolute ethanol and 0.1ml of water, then add 0.5g of hydroxypropyl cellulose and stir for 30min to obtain a solution. Dissolve 3ml of titanium tert-butoxide in 7ml of ethanol, slowly add it dropwise into the above solution with a syringe, reflux at 90°C for 110min, and centrifuge at 15,000rpm for 5min to obtain a precipitate. times, the precipitated holl...

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Abstract

The invention relates to preparation and applications of a medicinal composition of a NO-donating titanium dioxide derivative, for effectively realizing the treatment medication aiming at tumor, and realizing the diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation comprises the following steps: reacting hollow mesoporous titanium dioxide nano particles and mercaptopropyl triethoxysilane to obtain a sulfhydryl hollow mesoporous titanium dioxide compound, reacting the sulfhydryl hollow mesoporous titanium dioxide compound with tert-butyl nitrite to obtain the NO-donating titanium dioxide derivative, and finally, loading an antitumor drug such as a bioreductive agent. The preparation and applications have the advantages that the operation is convenient, the method is stable and reliable, the prepared NO-donating titanium dioxide and the medicinal composition of the NO-donating titanium dioxide have the advantages that the biocompatibility is good, the targeting ability is strong, the toxic and side effects are small, etc., in the aspect of tumor treatment, the ultrasonic therapy of TiO2, the anti-tumor therapy effect of NO, and the lethal effect of the bioreductive agent can be exerted, meanwhile, the early-stage diagnosis and later-stage treatment can be integrated by utilizing the ultrasonic imaging property of the generated NO gas, and therefore, the technical scheme belongs to an innovation in the tumor treatment medicines.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the preparation and application of the pharmaceutical composition of NO donor titanium dioxide derivatives. Background technique [0002] Surgery, radiotherapy, and chemotherapy are the three most commonly used means of tumor treatment. However, surgery can only remove tumors that are visible to the naked eye, but it is difficult to remove invisible subclinical lesions; traditional chemotherapy often has problems of poor targeting and dose-limiting toxicity; and sonodynamic therapy uses ultrasound to have a strong effect on biological tissues. Penetration ability, and activate some sonosensitizers to generate active oxygen to exert anti-tumor effect, without damage to normal cells, so it is a safer and more efficient means of tumor treatment. Titanium dioxide (TiO 2 ) as an excellent sonosensitizer has been widely used in sonodynamic therapy due to its high biocompatibility, good stabil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K47/02A61K47/04A61K41/00A61K31/407A61P35/00
CPCA61K9/0019A61K9/0024A61K9/0053A61K31/407A61K41/0033A61K47/02A61K49/221A61K2300/00
Inventor 张振中冯倩华张宛霞侯琳
Owner ZHONGSHUAI PHARMA SCI & TECH CO LTD
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