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Method for synthesis of macrocyclic musk lactone

A synthesis method and technology of musk lactone, which is applied in the synthesis of cosmetic additives, synthesis of macrocyclic muskone and macrocyclic musk lactone, health care products, and pharmaceutical fields, can solve the problem of no synthetic fragrance cyclopentadecanolide, etc. , to achieve the effect of preventing cerebral neurasthenia, improving activity and high yield

Inactive Publication Date: 2017-02-15
昆明酷特利生物科技有限公司
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  • Abstract
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  • Claims
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Problems solved by technology

[0013] At present, there is no report on the method of synthesizing spice cyclopentadecanolide from garlic fruit oil in the prior art

Method used

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  • Method for synthesis of macrocyclic musk lactone
  • Method for synthesis of macrocyclic musk lactone
  • Method for synthesis of macrocyclic musk lactone

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Embodiment 1

[0030] 1. Preparation and purification of tetracos-15-enoic acid.

[0031] 1.1 Extraction of garlic fruit oil:

[0032] Garlic nuts are finely ground in a mortar, wrapped with filter paper, put into a Soxhlet extractor, and extracted with petroleum ether as a solvent under reflux for 6 hours. The extracted garlic oil is evaporated to dryness and stored for later use.

[0033] 1.2 Preparation and purification of tetracos-15-enoic acid.

[0034] 1.2.1 Saponification and acidification of garlic fruit oil:

[0035] Add NaOH to denatured alcohol and stir to dissolve. After the dissolution is complete, add it to a container containing garlic fruit oil, stir and saponify in the electric heating mantle for 4 hours; Wash with hot water several times to obtain mixed fatty acids for later use.

[0036] 1.2.2 Tetracos-15-enoic acid recrystallization:

[0037]Using absolute ethanol, acetone, and pyridine as a single solvent, carry out recrystallization, and detect the purity by gas pha...

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Abstract

A method for synthesis of senior spice high-value musk spice cyclopentadecanolide (macrocyclic musk lactone) from malania oleifera oil is provided; the cyclopentadecanolide is prepared by taking the malania oleifera oil as raw material through saponification, acidification, recrystallization, ozonization, reduction, esterification and ring closing. The method has the advantages of high yield, good benefits and low cost, and overcomes the defects of complex production process, relatively low yield, relatively high cost and no formation of market advantages in the prior art. The malania oleifera oil contains 40%-60% of 15-tetracosenic acid, and is an ideal raw material for synthesis of the high-value musk spice. The 15-tetracosenic acid is an essential nutrient for brain development, has important roles in improving the cranial nerve activity and preventing encephalasthenia, has good curative effect on cardiovascular and human body autoimmune deficiency diseases, and can be used as medicines and health care products.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of chemical products, and specifically relates to a method for synthesizing additives for medicines, health care products and cosmetics, and more specifically, relates to a method for synthesizing macrocyclic muskone and macrocyclic muscolide from garlic fruit oil. [0003] Background technique: [0004] Musk is a precious animal spice. As early as the Eastern Han Dynasty, musk was known as the king of spices. It has strong diffusivity and inducing power, has a special soft and elegant aroma, good fragrance-increasing effect and excellent fragrance-fixing ability. It is an indispensable fixative in the deployment of high-end fragrances and is widely used in flavors and fragrances Industry, tobacco industry, food industry, daily chemical industry and other industries. In the blending of flavors and fragrances, as long as one ten-thousandth of musk is added, not only can the essence and perfuming produ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D313/00
CPCC07D313/00
Inventor 杨宇明王娟刘祥义施蕊陈汓
Owner 昆明酷特利生物科技有限公司
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