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Synthesis method of tetracycline HCl convenient for seed tank cleaning

A technology of tetracycline hydrochloride and a synthesis method, applied in the field of synthesis of tetracycline hydrochloride, can solve problems such as accumulation of dirt at the bottom of an interlayer of a seed tank, and achieve the effects of few steps, easy industrial production and mild reaction conditions

Inactive Publication Date: 2017-02-15
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide the synthetic method of the tetracycline hydrochloride that is convenient to clean seed jar, solves the problem that the interlayer bottom of the seed jar in the synthetic technique of existing tetracycline hydrochloride accumulates dirt

Method used

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  • Synthesis method of tetracycline HCl convenient for seed tank cleaning

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Effect test

Embodiment 1

[0031] Such as figure 1 Shown, the synthetic method of the tetracycline hydrochloride that is convenient to clean seed jar, comprises the following steps:

[0032] 1) Preparation of fermentation broth: inoculate the spores of Streptomyces aureus on the spore culture medium and cultivate them for 5 days until the spores mature, then transfer the prepared spores to the seed tank for culture, and then transfer to fermentation culture after the seed tank culture is completed. The seed tank includes a tank body 1, the interior of the tank body 1 is provided with a stirring device 3, the outer wall of the tank body 1 is provided with a sandwich structure 2, the lower end of the sandwich structure 2 is provided with a water inlet 21, and the upper end of the sandwich structure 2 is provided with an outlet. Nozzle 22, the bottom of the interlayer structure 2 is set as a circular arc structure, the bottom of the interlayer structure 2 is provided with a sewage pipe 5, the sewage pipe 5...

Embodiment 2

[0044] Such as figure 1 Shown, the synthetic method of the tetracycline hydrochloride that is convenient to clean seed jar, comprises the following steps:

[0045] 1) Preparation of fermentation broth: inoculate the spores of Streptomyces aureus on the spore culture medium and cultivate them for 5 days until the spores mature, then transfer the prepared spores to the seed tank for culture, and then transfer to fermentation culture after the seed tank culture is completed. The seed tank includes a tank body 1, the interior of the tank body 1 is provided with a stirring device 3, the outer wall of the tank body 1 is provided with a sandwich structure 2, the lower end of the sandwich structure 2 is provided with a water inlet 21, and the upper end of the sandwich structure 2 is provided with an outlet. Nozzle 22, the bottom of the interlayer structure 2 is set as a circular arc structure, the bottom of the interlayer structure 2 is provided with a sewage pipe 5, the sewage pipe 5...

Embodiment 3

[0057] Such as figure 1 Shown, the synthetic method of the tetracycline hydrochloride that is convenient to clean seed jar, comprises the following steps:

[0058] 1) Preparation of fermentation broth: Inoculate the spores of Streptomyces aureus on the spore medium and cultivate them for 5 days until the spores mature, then transfer the prepared spores to the seed tank for culture, and then transfer to fermentation culture after the seed tank culture is completed. The seed tank includes a tank body 1, the interior of the tank body 1 is provided with a stirring device 3, the outer wall of the tank body 1 is provided with a sandwich structure 2, the lower end of the sandwich structure 2 is provided with a water inlet 21, and the upper end of the sandwich structure 2 is provided with an outlet. Nozzle 22, the bottom of the interlayer structure 2 is set as a circular arc structure, the bottom of the interlayer structure 2 is provided with a sewage pipe 5, the sewage pipe 5 is prov...

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Abstract

The invention discloses a synthesis method of tetracycline HCl convenient for seed tank cleaning. The synthesis method comprises the following steps: 1) preparing a fermentation broth: inoculating a spore medium with streptomyces aureus spores and conducting cultivation for 5 days, then transferring the prepared spores to a seed tank and cultivating the spores, and after conducting cultivation in the seed tank, conducting fermentation cultivation; 2) acidifying the fermentation broth; 3) preparing tetracycline coarse alkali: adding calcium chloride to the fermentation broth and conducting precipitation so as to obtain a calcium salt precipitate, and regulating the pH value of the calcium salt precipitate to 4.6-4.8; 4) preparing a finished tetracycline alkali product; 5) preparing the tetracycline hydrochloride: adding the finished tetracycline alkali product to a butanol solution, adding hydrochloric acid and conducting filtration, and conducting heating crystallization so as to obtain the tetracycline hydrochloride; and 6) preparing the tetracycline HCl: processing the tetracycline hydrochloride by virtue of carbonate so as to obtain the tetracycline HCl. The synthesis process provided by the invention has fewer steps and is mild in reaction conditions, and the synthesis process can easily implement the industrial production of the tetracycline HCl; therefore, a new thinking is provided for the production of the tetracycline HCl.

Description

technical field [0001] The invention relates to the technical field of drug synthesis, in particular to a synthesis method of tetracycline hydrochloride which is convenient for cleaning seed tanks. Background technique [0002] The molecular formula of tetracycline hydrochloride is: C 22 h 24 N 2 o 8 • HCl, molecular weight 480.91. Yellow crystal, odorless. Bitter. Hygroscopic. When exposed to light, the color gradient becomes darker. Soluble in water, in methanol. Ethanol, insoluble in ether, hydroxyl. It is an antibacterial substance isolated from the culture solution of the actinomycetes Streptomycesaureofaciens, and it is effective against Gram-positive bacteria, negative bacteria, Rickettsia, filter viruses, spirochetes and even protozoa. It has a good inhibitory effect, but it is ineffective against Mycobacterium tuberculosis and Proteus. [0003] Tetracycline hydrochloride is the first generation of tetracycline antibiotics. It has broad-spectrum antibacter...

Claims

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Application Information

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IPC IPC(8): C12P29/00C12R1/49
CPCC12P29/00
Inventor 卢朝成廖成斌
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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