Medicinal preparation suitable for Duchenne muscular dystrophy and preparation method thereof

A Duchenne muscle nutrition and pharmaceutical preparation technology, which is applied in the field of medicine, can solve the problems of insoluble particles becoming larger, insoluble particles and potency increasing, and potency decreasing, and achieve the effects of stable quality, improved safety, and convenient use

Inactive Publication Date: 2017-04-26
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect of this patented technology described in this patents relating to improving treatments against genetic diseases caused by mutations affecting specific genes or proteins involved in skeletal disease are improved stability over existing methods while maintaining their ability to detect these changes quickly during treatment sessions without changing them too much. This results in better patient outcomes when used alone compared to other therapies like rhenium oxychloride (REO) or calcium channel blockers.

Problems solved by technology

Technological Problem addressed in this patented technical problem relates to finding ways to improve symptoms associated with Musculus necrosis caused by Becker Muscule Disease Type B (BMDB), particularly when older individuals develop resistance to current medicines such as Diazoxane® and Tacrolimus. Current methods require repeated dosage overtime and may cause complications like bleeding or cardiovascular events. Therefore, There exists a desire to provide better options than existing alternatives without compromising safety concerns.

Method used

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  • Medicinal preparation suitable for Duchenne muscular dystrophy and preparation method thereof
  • Medicinal preparation suitable for Duchenne muscular dystrophy and preparation method thereof
  • Medicinal preparation suitable for Duchenne muscular dystrophy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription

[0035]

[0036]

[0037] Preparation Process

[0038] a. Ampoule treatment: wash the ampoule through an ultrasonic bottle washing machine, sterilize and dry it at 290°C in a tunnel type sterilization dryer, and transfer it to the filling room for standby;

[0039] B, preparation: 1. Eteplirsen and disodium glycyrrhizinate of the formula amount are weighed and dissolved in water for injection accounting for 30% of the total volume, and stirred and mixed for 15 minutes;

[0040] 2. Add water for injection to 1 Chinese medicinal liquid to 85% of the total volume, stir and mix evenly, add the prescribed amount of meglumine, stir the medicinal liquid to a colorless and clear liquid, and adjust the pH value with a pH regulator;

[0041] 3. Dilute to the total volume with water for injection, adjust the pH value with a pH regulator again, take a sample to test the intermediate product solution, and prepare for potting after passing the test.

[0042] c. ...

Embodiment 2

[0046] prescription

[0047]

[0048] Preparation process: with embodiment 1

Embodiment 3

[0050] prescription

[0051]

[0052]

[0053] Preparation process: with embodiment 1

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Abstract

The invention belongs to the field of medicine technology, and concretely relates to a medicinal preparation suitable for Duchenne muscular dystrophy. The preparation comprises the following components: an active component Eteplirsen, sodium chloride, disodium glycyrrhizate, meglumine, a pH conditioning agent, and injection water. The quality is stable, long-term acceleration tests and investigations show that appearance and properties, pH value, visible foreign matters, insoluble particles and titer are not obviously changed; at the same time, after the preparation and 0.9% sodium chloride are compatible, the preparation is placed at a room temperature for a long time, insoluble particles and titer are not obviously changed, the preparation is greatly convenient for clinic usage, and usage safety of patients is improved.

Description

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Claims

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Application Information

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Owner JIAMUSI UNIVERSITY
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