Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tamarix ramosissima Ledeb extract and application thereof in preparation of medicine for treatment of rheumatoid arthritis

An extract and rheumatoid technology are applied to the red willow extract and its application field in the preparation of medicines for treating rheumatoid arthritis, so as to achieve the effects of reducing the content, alleviating the inflammatory response, and improving the pressure and pain tolerance value.

Inactive Publication Date: 2017-04-26
NINGXIA MEDICAL UNIV
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature reporting that tamarisk or its extracts have biological activity in treating rheumatoid arthritis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tamarix ramosissima Ledeb extract and application thereof in preparation of medicine for treatment of rheumatoid arthritis
  • Tamarix ramosissima Ledeb extract and application thereof in preparation of medicine for treatment of rheumatoid arthritis
  • Tamarix ramosissima Ledeb extract and application thereof in preparation of medicine for treatment of rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of tamarisk extract.

[0019] Take 500g of dried red willow branches, pulverize them, extract 3 times with 4L of 70% ethanol under reflux, filter to remove the medicinal residues, combine the filtrate after 3 extractions, concentrate the obtained filtrate under reduced pressure to a relative density above 1.20, and dry it in vacuum for 12 hours Obtain 135g of extract, that is, extract of tamarisk.

Embodiment 2

[0021] To investigate the effect of tamarisk extract on the appearance of diseased joints in AA model rats.

[0022] Material animal: SD male rat, about 250g;

[0023] Drugs: Freund's complete adjuvant; tripterygium glycosides tablets;

[0024] Method: Male SD rats were randomly divided into a blank control group, a model group, a red willow extract group prepared in Example 1, and a positive drug (tripterygium glycosides) group. Except for the blank group, each rat was injected with 0.1 mL of Freund's complete adjuvant in the middle of the left hind toe to establish a rat adjuvant arthritis model. From the next day after modeling, the rats in the red willow extract group were gavaged with red willow extract (80mg / kg) every day according to their body weight, and the rats in the positive control group were gavaged with tripterygium glycosides solution every day. (20mg / kg), the rats in the blank group and the model group were intragastrically given an equal volume of normal s...

Embodiment 3

[0027] To investigate the effect of tamarisk extract on the pressure pain tolerance value of AA model rats.

[0028] Material animal: SD male rat, about 250g;

[0029] Drug: Freund's complete adjuvant; the red willow extract prepared in Example 1; tripterygium glycosides tablets;

[0030] Method: Male SD rats were randomly divided into blank control group, model group, red willow extract administration group and positive drug (tripterygium glycosides) group. Except for the blank group, each rat was injected with 0.1 mL of Freund's complete adjuvant in the middle of the left hind toe to establish a rat adjuvant arthritis model. From the next day after modeling, the rats in the red willow extract group were given intragastric administration of red willow extract (80 mg / kg) every day according to their body weight, the rats in the positive control group were given intragastric administration of tripterygium glycosides solution (20 mg / kg) every day, and the rats in the blank grou...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to medicines for treatment of rheumatoid arthritis and especially provides a Tamarix ramosissima Ledeb extract and an application thereof in preparation of a medicine for treatment of the rheumatoid arthritis. The extract is extracted from Tamarix ramosissima Ledeb which belongs to Tamarix. The preparation method of the Tamarix ramosissima Ledeb extract includes the steps of: air-drying and crushing branches of the Tamarix ramosissima Ledeb and performing reflux extraction with water or an ethanol water solution being 1-99% in concentration for 1-5 times, filtering an extraction liquid and concentrating the extraction liquid to obtain an extract concentrate, thus obtaining the Tamarix ramosissima Ledeb extract. The invention also provides the application of the Tamarix ramosissima Ledeb extract in preparation of a medicine for treatment of the rheumatoid arthritis. A test proves that the Tamarix ramosissima Ledeb extract has significant effect on the rheumatoid arthritis and can reduce inflammation reaction of lesion joints in a model mouse, and reduces the metatarsal swelling degree of an adjuvant arthritis rat model (AA model).

Description

technical field [0001] The invention relates to a medicine for treating rheumatoid arthritis, in particular to a red willow extract and its application in preparing medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic systemic autoimmune disease mainly characterized by joint lesions. Its pathogenesis is still unclear. It is clinically believed that the pathogenesis of RA is mainly due to autoimmune dysfunction in patients. , leading to allergic reactions, degeneration of anti-inflammatory cells, deposition in joints and joint tissue deformity and disability. According to investigations, the incidence of RA worldwide is about 1-2%. The total number of RA patients in my country has exceeded 4 million, and the incidence is still on the rise. [0003] At present, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61P29/00A61P19/02
CPCA61K36/185A61K2236/333A61K2236/39A61K2236/51
Inventor 姚遥李娟李玮琦姜成帅
Owner NINGXIA MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com