Novel ketoprofen patch and preparation method thereof

A patch and main drug ketone technology, applied in the field of western medicine preparations, can solve the problems of unsuitable capsule preparations, and achieve the effects of easy quality control, small molecular weight, and meeting the needs of clinical treatment

Inactive Publication Date: 2017-05-24
毛嘉明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to avoid irritation to the gastrointestinal tract, it should be taken after meals, and the cap...

Method used

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  • Novel ketoprofen patch and preparation method thereof
  • Novel ketoprofen patch and preparation method thereof
  • Novel ketoprofen patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Ketoprofen 1.20kg, polyethylene glycol 6000 9.27kg, lauryl nitrogen Ketone 3.5kg, hot melt adhesive 63.17kg.

[0029] Its preparation method comprises the following steps:

[0030] (1) Weigh the prescribed amount of polyethylene glycol 6000 and pour it into a stainless steel bucket, then slowly add the weighed ketoprofen, and finally add lauryl nitrogen For ketones, put the stainless steel bucket in an electric blast drying oven, set the temperature at 120±5°C, and stir the ingredients at intervals to make them evenly mixed. Melt the drug until there are no visible particles;

[0031] (2) Open the sol tank, weigh the hot melt adhesive of the prescribed amount, put it into the melt tank, adjust the heating temperature of the melt tank to 130±5°C, and melt the glue block into a milky white paste;

[0032] (3) Transfer the melted hot melt adhesive from the melt tank to the vertical stirring filter, control the temperature of the vertical stirring filter at 95±5°C, add...

Embodiment 2

[0041] Ketoprofen 3.60kg, macrogol 6000 4.99kg, lauryl nitrogen Ketone 6.5kg, hot melt adhesive 51.69kg.

[0042] The preparation method is as in Example 1.

Embodiment 3

[0044] Ketoprofen 3.60kg, macrogol 6000 9.27kg, lauryl nitrogen Ketone 3.5kg, hot melt adhesive 51.69kg.

[0045] The preparation method is as in Example 1.

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PUM

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Abstract

The invention relates to a western medicine preparation, in particular to a method for preparing a ketoprofen patch. The ketoprofen patch comprises a lining material, a medicine storehouse and an anti-sticking material, wherein the medicine storehouse comprises active ingredients and adjuvant materials in parts by weight: 1.20-3.60 parts of main drug ketoprofen, 4.99-9.27 parts of a humectant, 3.5-6.5 parts of an absorption enhancer and 51.69-63.17 parts of a host material; preferably, the medicine storehouse comprises the following ingredients in parts by weight: 2.40 parts of main drug ketoprofen, 7.13 parts of a humectant, 4.99 parts of an absorption enhancer and 57.48 parts of a host material. The invention also provides the preparation method of the ketoprofen patch. The ketoprofen patch disclosed by the invention has the characteristics of being good in tissue compatibility, high in transdermal absorption efficiency, good in stickiness, easy to strip, odorless, simple in process, good in stability and the like, and can be used for treating rheumatoid arthritis clinically, and the total cure rate is 95%.

Description

technical field [0001] The present invention relates to a kind of western medicine preparation, especially a kind of method of ketoprofen patch. Background technique [0002] The chemical name of ketoprofen is α-methyl-3-benzoyl-phenylacetic acid (C 16 h 14 o 3 ), the molecular weight is 254.29. This product is a derivative of aryl propionic acid, which is a non-steroidal anti-inflammatory analgesic. In addition to inhibiting cyclooxygenase, this product also has the effect of inhibiting lipoxygenase and reducing bradykinin, thereby reducing the pain sensation at the site of inflammatory injury. Bradykinin together with prostaglandins can cause pain. Bradykinin can also cause uterine contraction, so this product is used for dysmenorrhea, mainly by inhibiting bradykinin, thereby inhibiting uterine contraction and analgesic effect. This product still has a certain central analgesic effect. Therefore, it is widely used clinically for various arthritis: rheumatoid arthrit...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61P19/02
CPCA61K9/7038A61K31/192
Inventor 毛嘉明
Owner 毛嘉明
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