Preparation method of Xuanmai Ganjie granules

A technology of Xuanmai Ganju and granules, which is applied in the field of preparation of Xuanmai Ganju granules, can solve problems such as easy oxidation and hydrolysis, generation of cinnamic acid or other components, reduction of active substance content of finished medicine, and reduction of drug treatment effect, etc., to achieve Haba Increase the content of Rusin, improve the effective transfer rate and content, and promote the effect of accumulation

Inactive Publication Date: 2017-05-24
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After testing, the extract concentrated by this conventional concentration method has a harpagoside content of 0.18-0.25 mg / g and a glycyrrhizic acid content of 3.87-6.45 mg / g. The granule harpagoside produced by this extract The content is 0.28-0.40mg / 10g granules, and the content of glycyrrhizinic acid is 6-10 mg / 10g granules. It is found through research that in the process of conventional decompression concentration, the temperature of the concentrate is as high as 75-85°C, and harpagoside is at this temperature It is easily oxidized and hydrolyzed to produce cinnamic acid or other components, and glycyrrhizic acid will be partially converted into other components, so the content of active ingredients harpagoside and glycyrrhizic acid in extracts and granules produced by this method are relatively high. Low, correspondingly, leading to a reduction in the content of active substances in the finished drug, which correspondingly reduces the therapeutic effect of the drug

Method used

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  • Preparation method of Xuanmai Ganjie granules
  • Preparation method of Xuanmai Ganjie granules
  • Preparation method of Xuanmai Ganjie granules

Examples

Experimental program
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Embodiment 1

[0031] 【Prescription】Scrophulariaceae 80g, Ophiopogon japonicus 80g, Licorice 80g, Platycodon grandiflorum 80g

[0032][Preparation method] The above four flavors are added with 8 times, 5 times, and 3 times the amount of medicinal materials, respectively, and decocted three times, for 1.5 hours for the first time, and for 1 hour each for the second and third times. Combine the decoction for three times, and filter , the filtrate was left to stand for 12 hours, and the supernatant was concentrated to a relative density of 1.32 g / ml (measured at 70-80°C), kept at 55°C, refluxed for 2.5 hours, and then the extract was collected, and an appropriate amount of sucrose was added to the extract And dextrin, made into granules, that is.

[0033] After testing, the content of harpagoside in the extract is 0.32mg / g, the content of glycyrrhizic acid is 9.61mg / g, the content of harpagoside in the finished granule is 0.50mg / 10g, and the content of glycyrrhizic acid is 14.9mg / 10g.

Embodiment 2

[0035] 【Prescription】Scrophulariaceae 80g, Ophiopogon japonicus 80g, Licorice 80g, Platycodon grandiflorum 80g

[0036] [Preparation method] The above four flavors are added with 8 times, 5 times, and 3 times the amount of medicinal materials, respectively, and decocted three times, for 1.5 hours for the first time, and for 1 hour each for the second and third times. Combine the decoction for three times, and filter , the filtrate was left to stand for 12 hours, and the supernatant was concentrated to a relative density of 1.32 g / ml (measured at 70-80°C), kept at 65°C, refluxed for 3.5 hours, and then the extract was collected, and an appropriate amount of sucrose was added to the extract And dextrin, made into granules, that is.

[0037] After testing, the content of harpagoside in the extract is 0.33mg / g, the content of glycyrrhizic acid is 10.21mg / g, the content of harpagoside in the finished granule is 0.52mg / 10g, and the content of glycyrrhizic acid is 15.8mg / 10g.

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Abstract

The invention provides a preparation method of Xuanmai Ganjie granules. The method comprises the following steps: decocting and concentrating radix scrophulariae, radix ophiopogonis, liquorice and platycodon grandiflorus; and performing refluxing treatment on the concentrate for 2.5-3.5 hours while keeping the refluxing temperature at 55-65 DEG C to finally obtain granules. In the finished product of Xuanmai Ganjie granules prepared in the invention, the contents of active ingredients, namely harpagoside and glycyrrhizic acid, are remarkably increased, and the treatment effect of the medicine is correspondingly enhanced, which is a great beneficial technical progress; and on the premise of neither increasing production equipment nor changing production flow, low cost and high yield are realized, and tremendous economic and social benefits are created by the most economical way.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of xuanmai ganju granules. Background technique [0002] Xuanmai Ganju Granules are composed of four medicinal materials: Scrophularia scrophulariae, Ophiopogon japonicus, Licorice and Platycodon grandiflorum. It has the effects of clearing heat, nourishing yin, eliminating phlegm and relieving throat. [0003] Scrophulariae Scrophulariae is the main medicine in this prescription. Scrophulariaceae Scrophulariae is a commonly used traditional Chinese medicine. It is one of the representative Chinese medicines for clearing away heat and cooling blood. Fire, relieve spots and oozing, brighten the throat, relieve urination, improve eyesight, loose tumors and carbuncles, treat typhoid fever, thirst, and inner fright, used for symptoms such as febrile disease hurting yin, fluid hurting constipation, red eyes, and sore throat. Ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/16A61P11/10A61P11/04A61P11/02A61P1/02
CPCA61K36/808A61K9/1652A61K36/346A61K36/484A61K36/8968A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 卿光明余定祥钟瑛
Owner SICHUAN MEDCO PHARML
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