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Nutritional compositions containing phosphatidylserine powder

A technology of phosphatidylserine and composition, applied in the field of PS preparations, which can solve the problems of manufacturers, increased PS degradation and oxidation, logistics problems, etc.

Pending Publication Date: 2017-05-24
ENZYMOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation sequence exposes PS powder to oxygen, heat, and water for a long time and harmfully, thereby increasing the possibility of PS degradation and oxidation.
[0007] Furthermore, in large-scale production, the addition of PS powder before the spray-drying stage causes logistical problems and creates difficulties for manufacturers

Method used

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  • Nutritional compositions containing phosphatidylserine powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Preparation of PS powder using single phase reaction (Sample 1) . 140 g of an aqueous emulsion containing ethanol-purified soybean lecithin was mixed with a solution containing 41 gr of L-serine, 35 ml of acetate buffer, and 0.55 gr of phospholipase-D enzyme, and stirred at 40°C. After stirring for 36 hours, the solution was filtered through a Buchner filter to remove all water-soluble components. Disperse the solid in 140 ml of purified water for 30 minutes, and filter again. The wet solid was dried in a vacuum dryer to obtain a dry PS powder with a PS concentration of 58.8% as measured by HPLC. The dry powder is ground with 2% silica to obtain a free-flowing powder, where more than 20% (w / w) of the powder has a particle size of 500 microns or more.

Embodiment 2

[0076] Sieving sample 1 (preparing sample 2) . Sample 1 was sieved through a 250 micrometer screen to obtain a powder in which 97% (w / w) of the powder has a particle size of 250 micrometers or less.

Embodiment 3

[0078] Purification of sample 1 using alcohol solvent (preparation of sample 3) . 10 gr of sample 1 (before drying) was dispersed in 40 ml of ethanol, and the solution was stirred for 30 minutes. The solution was filtered through a Buchner filter to separate solids and filtrate. Collect the solids from the filter and repeat the same process two more times. The wet solid is dried in a vacuum dryer to obtain a dry PS powder. The dry powder is ground with 2% silica to obtain a free-flowing powder, where more than 20% (w / w) of the powder has a particle size of 500 microns or more.

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Abstract

Phosphatidylserine powder compositions of the present invention were found to provide more homogeneous dispersion and demonstrate reduced sedimentation, compared to conventional phosphatidylserine powders, when mixed without processing by high pressure homogenization in water or other liquids. The composition of the present invention comprises phosphatidylserine and at least 80% (w / w) of the composition has a particle size of 500 microns or less. Nutritional, nutraceutical, or pharmaceutical compositions including the phosphatidylserine powder compositions of the present invention are also provided. Process for preparing phosphatidylserine powder compositions according to the present invention is also provided and includes sieving.

Description

[0001] Invention field [0002] The present invention relates to a PS preparation having a predetermined particle size. Background technique [0003] Phosphatidylserine (PS) is the main acidic phospholipid in mammalian cell membranes, and it has been shown to play a key role in the function of neuronal membranes and change a variety of neurochemical systems (see Vance et al., Metabolism and functions of phosphatidylserine. Prog. Lipid Res. 2005; 44: 207-234). It has been shown that supplementation of PS to animal models can attenuate the aging effect of neurons and restore normal memory in a series of tasks. In humans, administration of PS to subjects with age-related memory impairment and patients with mild cognitive impairment resulted in an improvement in the consistency of performance in memory tests. Research conducted on children and adolescents tested the effects of PS supplementation on various cognitive and behavioral aspects. These studies confirm that PS improves chil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23J7/00C07F9/10A23L33/115
CPCA23J7/00C07F9/103A23L33/00A23L33/10A61K31/685A23G3/40A23L33/40A23V2002/00A61K9/1611
Inventor 亚瑟·维德贝里雅艾尔·赫尔佐克
Owner ENZYMOTEC