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Inhibition of maturation of dental biofilm and cariogenic properties

A biofilm, well-established technology for the inhibition of dental biofilm maturation and cariogenicity

Inactive Publication Date: 2017-05-24
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, inhibition of bacterial cariogenic activity poses a problem because bacteria tend to deposit in the mouth in the form of bacterial biofilms (surface-attached bacterial communities embedded in an extracellular matrix of polysaccharides, proteins, and DNA)

Method used

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  • Inhibition of maturation of dental biofilm and cariogenic properties
  • Inhibition of maturation of dental biofilm and cariogenic properties
  • Inhibition of maturation of dental biofilm and cariogenic properties

Examples

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Embodiment Construction

[0011] According to one embodiment, the present invention relates to the use of a small molecule inhibitor for the manufacture of a medicament for preventing the maturation of dental plaque biofilms and / or reducing the risk of diseases associated with the function derived from mature plaque biofilms, wherein the small molecule The inhibitor is characterized by the general formula 1:

[0012]

[0013] where R 1 may be a branched or unbranched hydrocarbon having 3 to 9 carbon atoms, and

[0014] where R 2 In particular may be a structure selected from:

[0015]

[0016] wherein each of the structures of formulas 2-5 can be further derivatized by at least one lower alkyl and / or at least one halogen group.

[0017] According to another embodiment, the present invention relates to the use of small molecule inhibitors for the manufacture of a medicament for preventing the maturation of dental plaque biofilms and / or reducing the risk of diseases associated with the function ...

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Abstract

The present invention relates to a small molecule inhibitor for use in the prevention of maturation of dental plaque biofilms. A further application may be the reduction of the risk for diseases associated with functions that derive from matured dental plaque biofilms. The invention also relates to the use of an effective amount of a small molecule inhibitor in a cosmetic product for the prevention of maturation of dental biofilms. The present invention also relates to oral compositions comprising an effective amount of a small molecule inhibitor suitable for the prevention of maturation of dental plaque biofilms. The present invention further relates to a device for application of oral compositions further comprising an oral composition comprising an effective amount of a small molecule inhibitor suitable for the prevention of maturation of dental plaque biofilms.

Description

technical field [0001] The present invention relates to the inhibition of plaque biofilm maturation and the cariogenicity of dental plaque biofilms, and products that inhibit the cariogenic activity of dental plaque biofilms. The invention also relates to devices using such products. Background technique [0002] Dental caries is an infection of bacterial origin that leads to demineralization and destruction of the hard tissues of the teeth. Tooth decay is caused by specific types of bacteria that produce lactic acid in the presence of fermentable carbohydrates such as sucrose, fructose and glucose (eg, from food residues that accumulate on tooth surfaces). The mineral content of teeth is sensitive to the increase in acidity caused by the production of lactic acid. [0003] The bacteria most responsible for dental caries are the mutans streptococci, most prominently Streptococcus mutans and Streptococcus sohrinus, and Lactobacillus. If left untreated, caries can lead to p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/16A61K31/167A61P1/02
CPCA61K31/16A61K31/167A61P1/02A61B17/244A61K8/0204A61K8/42A61K2800/28A61K2800/48A61K2800/524A61K2800/87A61K2800/92A61Q11/00
Inventor M·M·杰纳斯B·P·克罗姆W·克里拉尔德B·J·F·凯杰瑟尔
Owner KONINKLJIJKE PHILIPS NV