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A kind of fenbendazole suspension and preparation method thereof

A technology of fenbendazole and suspension, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. The problem of single suspension, etc., achieves the effect of good resuspensibility, mild operating conditions, and tight cohesion of steps.

Active Publication Date: 2019-09-03
JIANGXI BOLAI PHARMACY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, fenbendazole is generally in the form of a suspension, but the storage time of the suspension is relatively short, and stratification will occur after standing for a period of time, and there will be clots in the suspension. In the pre-preparation process, water is generally used as the wetting agent in the early stage, resulting in incomplete wetting of fenbendazole, and the suspending agent contained in the suspension is relatively simple, and the redispersion performance in the later stage is not good, and the wall hanging phenomenon is serious. The occurrence of these conditions will affect the efficacy of fenbendazole itself

Method used

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  • A kind of fenbendazole suspension and preparation method thereof
  • A kind of fenbendazole suspension and preparation method thereof
  • A kind of fenbendazole suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of fenbendazole suspension is as follows:

[0031] 1) Recipe: 8g of fenbendazole, 22ml of glycerin, 0.2g of methylcellulose, 0.1g of xanthan gum, 1.5g of Tween-80, 1.5g of Span-80, 0.1g of sodium benzoate, 1g of citric acid, Quantify water to 100ml;

[0032] 2) take by weighing the fenbendazole of the recipe quantity, add glycerol, Tween-80, Span-80 to moisten, and treat to moisten completely;

[0033] 3) Take 50ml of water, add sodium benzoate and citric acid, stir and dissolve, then add methylcellulose and disperse with a high-speed homogenizer for 2min;

[0034] 4) Mix the mixed solution of step 3) and the mixed solution of step 2) and stir evenly, disperse with a high-speed homogenizer for 1min, add water to quantify to 100ml, and disperse with a high-speed homogenizer for 2min.

Embodiment 2

[0036] The preparation method of fenbendazole suspension is as follows:

[0037] 1) Recipe quantity: fenbendazole 12g, glycerin 10ml, methylcellulose 0.1g, xanthan gum 0.8g, dextran-403g, Tween-80 0.5g, Span-80 0.6g, sodium benzoate 0.3g, Citric acid 3g, water to 100ml;

[0038] 2) take by weighing the fenbendazole of the recipe quantity, add glycerol, Tween-80, Span-80 to moisten, and treat to moisten completely;

[0039] 3) Take 50ml of water, add sodium benzoate, citric acid, and dextran-40, stir and dissolve, then add methyl cellulose and xanthan gum, disperse with a high-speed homogenizer for 3 minutes, and control the temperature at 30°C;

[0040] 4) Mix the mixed solution of step 3) and the mixed solution of step 2) and stir evenly, disperse with a high-speed homogenizer at 20°C for 2 minutes, add water to quantify to 100ml, and disperse with a high-speed homogenizer at 30°C for 3min.

Embodiment 3

[0042] The preparation method of fenbendazole suspension is as follows:

[0043] 1) Recipe: Fenbendazole 9g, Glycerin 15ml, Methylcellulose 0.7g, Xanthan Gum 0.1g, Dextran-402.5g, Tween-80 0.7g, Span-80 0.7g, Sodium Benzoate 0.25g , citric acid 2.5g, water to 100ml;

[0044] 2) take by weighing the fenbendazole of the recipe quantity, add glycerol, Tween-80, Span-80 to moisten, and treat to moisten completely;

[0045] 3) Take 50ml of water, add sodium benzoate, citric acid, and dextran-40, stir and dissolve, then add methylcellulose and xanthan gum, disperse with a high-speed homogenizer for 3 minutes, and control the temperature at 20°C;

[0046] 4) Mix the mixed solution of step 3) and the mixed solution of step 2) and stir evenly, disperse with a high-speed homogenizer at 30°C for 2min, add water to quantify to 100ml, and disperse with a high-speed homogenizer at 20°C for 3min.

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Abstract

The invention provides a fenbendazole suspension. The suspension per 100ml mainly comprises 8-12g of fenbendazole, 10-25ml of glycerinum, 0.1-0.7g of methylcellulose, 0.1-1.5g of xanthan gum, 0-3g of dextran-40, 0.1-1.5g of tween-80, 0.6-1.5g of span-80, 0.1-0.3g of sodium benzoate, 1-3g of citric acid and the balance of water. A preparation method comprises the following steps: mixing and wetting fenbendazole with glycerinum, tween-80 and span-80 to form mixed liquid; and after partially dissolving sodium benzoate, citric acid and dextran-40 with part of water, adding methylcellulose and xanthan gum and uniformly mixing, mixing the mixture with the mixed liquid, and then adding residual water and uniformly mixing to obtain the suspension.

Description

technical field [0001] The invention relates to the field of fenbendazole suspension preparation, in particular to a fenbendazole suspension and a preparation method thereof. Background technique [0002] Fenbendazole is a benzimidazole antiparasitic drug, which not only has high anthelmintic activity against gastrointestinal nematodes adults and larvae, but also has good effects on reticulate nematodes, fascioli and tapeworms, and extremely Strong insecticidal effect on eggs, fenbendazole is white or off-white powder, odorless, tasteless, insoluble in water, but soluble in glacial acetic acid and dimethyl sulfoxide, slightly hygroscopic, properties in dry state Stable and heat resistant, also stable at pH 2-6. [0003] Fenbendazole has been widely used at home and abroad. Fenbendazole is combined with the tubulin of worms to prevent the polymerization of microtubules, resulting in microtubule damage in the epidermis and intestinal cytoplasm of larvae or adults. , reduce t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/4184A61K47/38A61K47/26A61K47/36A61K47/10A61P33/10
Inventor 唐进波李艳梅张付华熊俊芳肖欣戈姜恒陈齐杰肖兴丽胡国彬胡瑞玲
Owner JIANGXI BOLAI PHARMACY CO LTD
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