Ciprofloxacin lactate soluble powder and preparation method thereof

Abstract

The invention relates to the field of veterinary drug preparations, and concretely relates to a ciprofloxacin lactate soluble powder. The ciprofloxacin lactate soluble powder comprises, by weight, 5-20 parts of ciprofloxacin lactate, 0.5-2 parts of a sweetener, 5-10 parts of a cosolvent and 68-89.5 parts of a solid dispersant. The invention also provides a preparation method of the ciprofloxacin lactate soluble powder. The preparation method comprises the following steps: respectively dissolving the sweetener, the cosolvent and the solid dispersant, uniformly mixing the above obtained three solutions, adding ciprofloxacin lactate, dissolving the ciprofloxacin lactate, and carrying out spray drying to obtain the finished product. The preparation method has the advantages of simplicity, easiness in operation, facilitation of the improvement of the preparation efficiency, and labor saving. The ciprofloxacin lactate soluble powder has the advantages of convenience in clinic use, good effect, good palatability and high bioavailability, and is suitable for large-scale standardized pig farm treatment and prevention administration.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a ciprofloxacin lactate soluble powder and a preparation method thereof. Background technique [0002] Ciprofloxacin lactate is the third-generation fluoroquinolone antibacterial drug, and it is one of the fluoroquinolones with higher antibacterial activity. It has a broad antibacterial spectrum, strong bactericidal power, and rapid action. Ciprofloxacin lactate has obvious antibacterial effect on gram-negative bacteria and positive bacteria, and has high activity on gram-positive bacteria and mycoplasma. , Staphylococcus aureus and other antibacterial activity is superior to norfloxacin and enrofloxacin, and ciprofloxacin lactate intramuscular absorption fast absorption, high bioavailability, has been widely used in livestock and poultry sensitive bacteria and mycoplasma caused by various an infectious disease. [0003] Ciprofloxacin Lactate Injection is...

AI Technical Summary

Problems solved by technology

[0003] Ciprofloxacin Lactate Injection is widely used clinically. However, with the improvement of the scale and intensification of pig farms, many pig farms often have thousands of sows, and some pig farms even reach 12,000 sows per pig. The stock of pig farms is often tens of thousands to hundreds of thousands. Once so many pigs get sick, they are often overwhelmed by injections alone (for economical reasons, there are not many veterinarians in pig farms)

Therefore adopt mixing material and drinking water to administer and just seem particularly necessary, but ciprofloxacin lactate tastes bitter, and oral administration palatability is relatively poor, has limited the application of drinking water administering greatly

Many pig farms in modern farming often use automatic feeding systems. There are often surplus materials in the feeding tower after the pig farms have an illness. After the pigs have finished eating these materials, adding medicine and mixing materials will delay the treatment time, and the surplus materials often cause inconvenience in dosing.

Moreover, the feed intake of pigs will decrease after the onset of the disease, which will affect the intake of drugs, all of which limit the oral administration of ciprofloxacin