Invisible nasal sticker preparation for pediatric anesthesia preoperative sedation and preparation method for invisible nasal strip preparation

A sedative and invisible technology, applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the risk of increased reflux and aspiration, increase the incidence of complications, and children’s acceptance Poor and other problems, to achieve the effect of convenient induction, calming the nerves and stress, and convenient and comfortable use

Inactive Publication Date: 2017-05-31
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the mainstream method of anesthesia induction for children in the world is the inhalation induction of gas anesthesia. When the inhalation induction cannot be implemented, the child must take orally or intramuscularly inject some anesthetics before entering the operating room for routine anesthesia induction. The scheme of pediatric anesthesia induction is intramuscular injection or intravenous injection of sedative drugs. Acupuncture will cause psychological harm to awake children and increase the incidence of various postoperative complications. The oral anesthesia induction dosage forms for children at home and abroad mainly include various types of syrup mixed The preparation of sedative drugs is administered by oral solid or liquid sedative drugs mixed with a certain amount of water to achieve the purpose of sedation. Taking the drug is not acceptable to some children. Drinking water before induction of anesthesia may increase the risk of reflux and aspiration. risk

Method used

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  • Invisible nasal sticker preparation for pediatric anesthesia preoperative sedation and preparation method for invisible nasal strip preparation
  • Invisible nasal sticker preparation for pediatric anesthesia preoperative sedation and preparation method for invisible nasal strip preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Using ultrasonic method, weigh about 4g of β-cyclodextrin and dissolve it in distilled water (45°C) to prepare a saturated solution. Add 1ml of the composition of jasmine essential oil and dexmedetomidine, mix well, ultrasonically treat at a constant temperature of 45°C for 30min, put it in the refrigerator for 24h, take it out for suction filtration, and wash with a little absolute ethanol for 3 times. Dry the powder in a vacuum dryer for 24 hours to obtain the inclusion compound of β-cyclodextrin;

[0031] (2) Take 5g of gelatin and add dissolved amount of water to soak for 4-8 hours, add 5g of polyvinyl alcohol and add dissolved amount of water to soak for 4-8 hours, stir the polyvinyl alcohol solution in a water bath at 70°C, and slowly dissolve it when it is completely dissolved Add gelatin solution, stir to dissolve completely, lower the temperature to 50°C, add 10g of hyaluronic acid, 10g of glycerol, and 5g of β-cyclodextrin inclusion compound, stir well, po...

Embodiment 2

[0034] (1) Using ultrasonic method, weigh about 4g of β-cyclodextrin and dissolve it in distilled water (45°C) to prepare a saturated solution. Add 1ml of the composition of rose essential oil and dexmedetomidine, mix well, ultrasonically treat at a constant temperature of 45°C for 30min, store in the refrigerator for 24h, take it out for suction filtration, and wash 3 times with a little absolute ethanol. Dry the powder in a vacuum dryer for 24 hours to obtain the β-cyclodextrin inclusion compound.

[0035] (2) Take 5g of gelatin and add dissolved amount of water to soak for 4-8 hours, add 5g of polyvinyl alcohol and add dissolved amount of water to soak for 4-8 hours, stir the polyvinyl alcohol solution in a water bath at 70°C, and slowly dissolve it when it is completely dissolved Add gelatin solution, stir to dissolve completely, lower the temperature to 50°C, add 10g of hyaluronic acid, 10g of glycerol, and 5g of β-cyclodextrin inclusion compound, stir well, pour into a f...

Embodiment 3

[0038] (1) Using ultrasonic method, weigh about 4g of β-cyclodextrin and dissolve it in distilled water (45°C) to prepare a saturated solution. Add magnolia essential oil and 1ml of the composition of dexmedetomidine, mix well, ultrasonically treat at a constant temperature of 45°C for 30min, put it in the refrigerator for 24h, take it out for suction filtration, and wash with a little absolute ethanol for 3 times. Dry the powder in a vacuum dryer for 24 hours to obtain the β-cyclodextrin inclusion compound.

[0039] (2) Take 5g of gelatin and add dissolved amount of water to soak for 4-8 hours, add 5g of polyvinyl alcohol and add dissolved amount of water to soak for 4-8 hours, stir the polyvinyl alcohol solution in a water bath at 70°C, and slowly dissolve it when it is completely dissolved Add gelatin solution, stir to dissolve completely, lower the temperature to 50°C, add 10g of hyaluronic acid, 10g of glycerol, 5g of β-cyclodextrin inclusion compound, stir well, pour int...

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Abstract

The invention discloses an invisible nasal sticker preparation for pediatric anesthesia preoperative sedation and a preparation method for the invisible nasal sticker preparation. Such a nasal sticker comprises an elastic biocolloid prepared from a biological skeleton material and a medicinal beta-cyclodextrin inclusion complex and a transparent back sticker. According to the nasal sticker, a high polymer biological material is adopted as a carrier, so that the nasal sticker has the advantages of stable and remarkable efficacy, small and invisible structure, convenience and comfort for use, capability of targeted delivery at an acupoint, fast action and the like. The nasal sticker has the remarkable effects that the nasal sticker preparation is applied to the Yingxiang acupoint or the nasal cavity of a child patient to be operated to make a sedative dexmedetomidine hydrochloride in the nasal sticker preparation rapidly absorbed by the nasal mucosa, so that the aim of sedation before anesthesia without influence on breathing is fulfilled, and the adverse psychological effects of muscular injection or intravenous injection on the child patient are avoided.

Description

technical field [0001] The invention belongs to anesthetics in the field of medicine, and in particular relates to an invisible nasal patch preparation for preoperative sedation of children under anesthesia and a preparation method thereof. Background technique [0002] At present, the mainstream method of anesthesia induction for children in the world is inhalation induction of gas anesthesia. When inhalation induction cannot be implemented, children must take orally or intramuscularly inject some anesthetics before entering the operating room for routine anesthesia induction. The scheme of pediatric anesthesia induction is intramuscular injection or intravenous injection of sedative drugs. Acupuncture will cause psychological harm to awake children and increase the incidence of various postoperative complications. The oral anesthesia induction dosage forms for children at home and abroad mainly include various types of syrup mixture The preparation of sedative drugs is adm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K36/63A61K36/738A61K36/575A61K36/53A61K31/4174A61K47/69A61P25/20
CPCA61K9/7023A61K31/4174A61K36/53A61K36/575A61K36/63A61K36/738A61K47/42A61K2300/00
Inventor 唐朝亮夏中元
Owner WUHAN UNIV
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